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Differential Association of Vitamin D Deficiency With Albuminuria by Sex in the Korean General Population: A Cross-sectional Study of the Korea National Health and Nutrition Examination Survey 2011-2012
Yongwoo Jeon, Jaeyong Shin, Jong Hyun Jhee, Youngdae Cho, Eun-Cheol Park
J Prev Med Public Health. 2018;51(2):92-99.   Published online February 6, 2018
DOI: https://doi.org/10.3961/jpmph.17.005
  • 6,706 View
  • 185 Download
  • 2 Crossref
AbstractAbstract PDFSupplementary Material
Objectives
Albuminuria has emerged as a biomarker for several medical conditions, and vitamin D has received attention due to its associations with various disorders. We evaluated the association between low serum vitamin D levels and prevalent albuminuria by sex in the Korean general population. Methods: We analyzed 9823 participants (4401 males, 5422 females) from the Korea National Health and Nutrition Examination Survey 2011-2012 (KNHANES V-2), and categorized them as having a normal range of vitamin D levels, vitamin D insufficiency, or vitamin D deficiency. A multivariable logistic regression model was used to compare the risk of albuminuria across these groups. Stratified analyses were conducted by smoking status, obesity, and renal function. Results: Albuminuria was found in 325 of the 4401 male participants (7.4%) and in 455 of the 5422 female participants (8.4%). Among the males, vitamin D deficiency was associated with an odds ratio (OR) for albuminuria of 1.78 (95% confidence interval [CI], 1.07 to 2.97, p<0.05). However, such an association was not found in females. The association was stronger in male current smokers (OR, 3.54; 95% CI, 1.47 to 8.50; p=0.005). Conclusions: The findings of this study suggest that sex differences exist in the association between serum vitamin D deficiency and albuminuria. Additionally, we observed that the association was stronger in current smokers than in the overall male population, but was not seen in non-smokers. Therefore, different approaches by sex and smoking status might be needed when considering using vitamin D as a biomarker for renal function.
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Citations

Citations to this article as recorded by  
  • Association between environmental chemical exposure and albumin-to-creatinine ratio is modified by hypertension status in women of reproductive age
    Gowoon Lee, Sunmi Kim, Inae Lee, Habyeong Kang, Jung Pyo Lee, Jeonghwan Lee, Young Wook Choi, Jeongim Park, Gyuyeon Choi, Kyungho Choi
    Environmental Research.2023; 231: 116234.     CrossRef
  • Long-term vitamin D deficiency promotes renal fibrosis and functional impairment in middle-aged male mice
    Zhi-Hui Zhang, Biao Luo, Shen Xu, Zhi-Cheng Zhang, Wei-Yang Xing, Yuan-Hua Chen, Cheng Zhang, Hua Wang, Dong-Dong Xie, De-Xiang Xu
    British Journal of Nutrition.2021; 125(8): 841.     CrossRef
The Association Between Serum Albumin Levels and Metabolic Syndrome in a Rural Population of Korea
Hye Min Cho, Hyeon Chang Kim, Ju-Mi Lee, Sun Min Oh, Dong Phil Choi, Il Suh
J Prev Med Public Health. 2012;45(2):98-104.   Published online March 31, 2012
DOI: https://doi.org/10.3961/jpmph.2012.45.2.98
  • 11,034 View
  • 106 Download
  • 19 Crossref
AbstractAbstract PDF
Objectives

A positive association between serum albumin levels and metabolic syndrome has been reported in observation studies, but it has not been established in the Korean population. The purpose of this study was to evaluate the association between serum albumin levels and the presence of metabolic syndrome among a sample of apparently healthy Korean adults.

Methods

This cross-sectional study analyzed data of 3189 community-dwelling people (1189 men and 2000 women) who were aged 40 to 87 years and were living in a rural area in Korea. Serum albumin levels were classified into quartile groups for each sex. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines with an adjusted waist circumference cut-off value (≥90 cm for men and ≥85 cm for women). An independent association between serum albumin levels and metabolic syndrome was assessed by multiple logistic regression analysis.

Results

Higher serum albumin levels were associated with increased prevalence of metabolic syndrome. The odds ratio (95% confidence interval) of the prevalence of metabolic syndrome for the highest versus the lowest serum albumin quartiles was 2.81 (1.91 to 4.14) in men and 1.96 (1.52 to 2.52) in women, after adjusting for age, smoking status, alcohol consumption, and physical activity. When each metabolic abnormality was analyzed separately, higher serum albumin levels were significantly associated with hypertriglyceridemia and hyperglycemia in both sexes, and with abdominal obesity in men.

Conclusions

These results suggest that higher serum albumin levels are positively associated with an increased risk of metabolic syndrome in Korean adults.

Summary

Citations

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    Internal Medicine.2024; 63(2): 159.     CrossRef
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    Andrea Cremaschi, Maria De Iorio, Narasimhan Kothandaraman, Fabian Yap, Mya Thway Tint, Johan Eriksson
    Statistics in Medicine.2024; 43(6): 1135.     CrossRef
  • Metabolic syndrome: comparison of three diet-induced experimental models
    Alexandra Petrova, Rumyana Simeonova, Christina Voycheva, Yonko Savov, Lyubomir Marinov, Vessela Balabanova, Reneta Gevrenova, Dimitrina Zheleva-Dimitrova
    Pharmacia.2023; 70(4): 1539.     CrossRef
  • The clinical role of serum albumin in Organophospate poisoning
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    Adebowale Emmanuel Aladejana, Elizabeth Bosede Aladejana
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    Clinical Nutrition.2020; 39(1): 258.     CrossRef
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    Samuel Seidu, Setor K. Kunutsor, Kamlesh Khunti
    Scandinavian Cardiovascular Journal.2020; 54(5): 280.     CrossRef
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    Chronobiology in Medicine.2020; 2(4): 175.     CrossRef
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    Seung Won Lee, Hyeon Chang Kim, Chungmo Nam, Hae-Young Lee, Song Vogue Ahn, Young A Oh, Il Suh
    Hypertension Research.2019; 42(3): 428.     CrossRef
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    BMC Nephrology.2019;[Epub]     CrossRef
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    Journal of Diabetes and its Complications.2018; 32(1): 61.     CrossRef
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    Clinical and Experimental Hypertension.2018; 40(1): 16.     CrossRef
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JPMPH : Journal of Preventive Medicine and Public Health