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- Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers
- Jong-Myon Bae
- J Prev Med Public Health. 2018;51(5):263-264. Published online July 8, 2018
- DOI: https://doi.org/10.3961/jpmph.18.076
- 5,044 View
- 139 Download
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Abstract
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Supplementary Material - Based on epidemiological and genomic characteristics, lung cancer in never smokers (LCNS) is a different disease from lung cancer in smokers. Based on current research, the main risk factor for LCNS may be air pollution. A recent case-control study in Koreans reported that nitrogen dioxide (NO2) may be a risk factor for LCNS. Additionally, a cohort study showed that exposure to NO2 was associated with significant hypomethylation. Thus, epigenetic epidemiology studies are needed in the near future to evaluate the carcinogenesis of LCNS according to chronic exposure to air pollution and/or viral infections.
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SummaryOriginal Articles
- Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study
- Jonghyuk Choi, Sanghyuk Bae, Hyungryul Lim, Ji-Ae Lim, Yong-Han Lee, Mina Ha, Ho-Jang Kwon
- J Prev Med Public Health. 2017;50(6):377-385. Published online November 7, 2017
- DOI: https://doi.org/10.3961/jpmph.17.099
- 23,996 View
- 222 Download
- 23 Crossref
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Abstract
PDFSupplementary Material
- Objectives
Although mercury (Hg) exposure is known to be neurotoxic in humans, its effects on liver function have been less often reported. The aim of this study was to investigate whether total Hg exposure in Korean adults was associated with elevated serum levels of the liver enzymes aspartate aminotransferase (AST), alanine transaminase (ALT), and gamma-glutamyltransferase (GGT).
Methods
We repeatedly examined the levels of total Hg and liver enzymes in the blood of 508 adults during 2010-2011 and 2014-2015. Cross-sectional associations between levels of blood Hg and liver enzymes were analyzed using a generalized linear model, and nonlinear relationships were analyzed using a generalized additive mixed model. Generalized estimating equations were applied to examine longitudinal associations, considering the correlations of individuals measured repeatedly.
Results
GGT increased by 11.0% (95% confidence interval [CI], 4.5 to 18.0%) in women and 8.1% (95% CI, -0.5 to 17.4%) in men per doubling of Hg levels, but AST and ALT were not significantly associated with Hg in either men or women. In women who drank more than 2 or 3 times per week, AST, ALT, and GGT levels increased by 10.6% (95% CI, 4.2 to 17.5%), 7.7% (95% CI, 1.1 to 14.7%), and 37.5% (95% CI,15.2 to 64.3%) per doubling of Hg levels, respectively, showing an interaction between blood Hg levels and drinking.
Conclusions
Hg exposure was associated with an elevated serum concentration of GGT. Especially in women who were frequent drinkers, AST, ALT, and GGT showed a significant increase, with a significant synergistic effect of Hg and alcohol consumption. -
Summary
Citations
Citations to this article as recorded by
- Selenium and zinc alleviate hepatotoxicity induced by heavy metal mixture (cadmium, mercury, lead and arsenic) via attenuation of inflammo‐oxidant pathways
Harrison Ozoani, Anthonet N. Ezejiofor, Kenneth O. Okolo, Chinna N. Orish, Ana Cirovic, Aleksandar Cirovic, Orish E. Orisakwe
Environmental Toxicology.2024; 39(1): 156. CrossRef - Deleterious effects of mercury contamination on immunocompetence, liver function and egg volume in an antarctic seabird
Andrés E. Ibañez, William F. Mills, Paco Bustamante, Lara M. Morales, Diego S. Torres, Beatriz D' Astek, Rocío Mariano-Jelicich, Richard A. Phillips, Diego Montalti
Chemosphere.2024; 346: 140630. CrossRef - Letter to the editor: In utero exposure to mercury is associated with increased susceptibility to liver injury and inflammation in childhood
Muhammad Zawar Asif, Muhammad Umair, Muhammad Shehryar
Hepatology.2023; 77(2): E38. CrossRef - Associations of blood metals with liver function: Analysis of NHANES from 2011 to 2018
Wenjie Li, Xinyan Li, Jing Su, Han Chen, Ping Zhao, Haisheng Qian, Xin Gao, Qiang Ye, Guoxin Zhang, Xuan Li
Chemosphere.2023; 317: 137854. CrossRef - Association of Blood Mercury Level with Liver Enzymes in Korean Adults: An Analysis of 2015–2017 Korean National Environmental Health Survey
Jin-Wook Chung, Dilaram Acharya, Jitendra Kumar Singh, Joon Sakong
International Journal of Environmental Research and Public Health.2023; 20(4): 3290. CrossRef - Environment-wide association study of elevated liver enzymes: results from the Korean National Environmental Health Survey 2018–2022
Youngchan Chi, Jong-Tae Park, Sewhan Na, Kyeongmin Kwak
Annals of Occupational and Environmental Medicine.2023;[Epub] CrossRef - Dissecting the role of cadmium, lead, arsenic, and mercury in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
Alexey A. Tinkov, Michael Aschner, Abel Santamaria, Alfred R. Bogdanov, Yousef Tizabi, Miriam B. Virgolini, Ji-Chang Zhou, Anatoly V. Skalny
Environmental Research.2023; 238: 117134. CrossRef - Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015–2017
Min Kyong Moon, Inae Lee, Aram Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Jeongim Park
Environmental Research.2022; 204: 111888. CrossRef - Identification source and human health risk assessment of potentially toxic metal in soil samples around karst watershed of Pangkajene, Indonesia
Anwar Mallongi, Ratna Dwi Puji Astuti, Ridwan Amiruddin, Muhammad Hatta, Annisa Utami Rauf
Environmental Nanotechnology, Monitoring & Management.2022; 17: 100634. CrossRef - Effects of lead and cadmium co-exposure on liver function in residents near a mining and smelting area in northwestern China
Jun Yan, Honglong Zhang, Jingping Niu, Bin Luo, Haiping Wang, Meng Tian, Xun Li
Environmental Geochemistry and Health.2022; 44(11): 4173. CrossRef - A novel nano-palladium embedded on the mesoporous silica nanoparticles for mercury vapor removal from air by the gas field separation consolidation process
Hamid Shirkhanloo, Farideh Golbabaei, Amir Vahid, Ali Faghihi Zarandi
Applied Nanoscience.2022; 12(5): 1667. CrossRef - Associations between lead, cadmium, mercury, and arsenic exposure and alanine aminotransferase elevation in the general adult population: an exposure–response analysis
Xiaoming Zhou, Yijun Feng, Zonglin Gong
Environmental Science and Pollution Research.2022; 29(35): 53633. CrossRef - Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases
Hai Duc Nguyen, Min-Sun Kim
Environmental Pollution.2022; 309: 119780. CrossRef - Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic
Mahdi Balali-Mood, Kobra Naseri, Zoya Tahergorabi, Mohammad Reza Khazdair, Mahmood Sadeghi
Frontiers in Pharmacology.2021;[Epub] CrossRef - Association between Blood Mercury Levels and Non-Alcoholic Fatty Liver Disease in Non-Obese Populations: The Korean National Environmental Health Survey (KoNEHS) 2012–2014
Yun-Jung Yang, Eun-Jung Yang, Kyongjin Park, Subin Oh, Taehyen Kim, Yeon-Pyo Hong
International Journal of Environmental Research and Public Health.2021; 18(12): 6412. CrossRef - In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood
Nikos Stratakis, Lucy Golden‐Mason, Katerina Margetaki, Yinqi Zhao, Damaskini Valvi, Erika Garcia, Léa Maitre, Sandra Andrusaityte, Xavier Basagana, Eva Borràs, Mariona Bustamante, Maribel Casas, Serena Fossati, Regina Grazuleviciene, Line Småstuen Haug,
Hepatology.2021; 74(3): 1546. CrossRef - The Relationship Between Embryotoxicity and Oxidative Stress Produced by Aluminum, Iron, Mercury, and Their Mixture on Cyprinus carpio
Selene Cano-Viveros, Marcela Galar-Martínez, Eloy Gasca-Pérez, Sandra García-Medina, Karina Ruiz-Lara, Leobardo Manuel Gómez-Oliván, Hariz Islas-Flores
Water, Air, & Soil Pollution.2021;[Epub] CrossRef - Tissue distribution of mercury and copper after Aarogyavardhini Vati treatment in rat model of CCl4 induced chronic hepatotoxicity
Shrirang Jamadagni, Pallavi Jamadagni, Binita Angom, Dhirendranath Mondal, Sachchidanand Upadhyay, Sudesh Gaidhani, Jayram Hazra
Journal of Ayurveda and Integrative Medicine.2020; 11(4): 508. CrossRef - Mercury exposure and premature mortality in the Grassy Narrows First Nation community: a retrospective longitudinal study
Aline Philibert, Myriam Fillion, Donna Mergler
The Lancet Planetary Health.2020; 4(4): e141. CrossRef - The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study
Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Journal of Trace Elements in Medicine and Biology.2020; 62: 126601. CrossRef - Blood mercury and liver enzymes: A pan-India retrospective correlation study
Krishnakumar Sivapandi, Amruta Velumani, Kallathikumar Kallathiyan, Sandhya Iyer, Prachi Sinkar
Toxicology and Industrial Health.2020; 36(12): 1019. CrossRef - Mercury in cetaceans: Exposure, bioaccumulation and toxicity
Joanna L. Kershaw, Ailsa J. Hall
Science of The Total Environment.2019; 694: 133683. CrossRef - Associations between mercury exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in US adolescents
Runsen Chen, Yang Xu, Cheng Xu, Yaqin Shu, Siyu Ma, Changgui Lu, Xuming Mo
Environmental Science and Pollution Research.2019; 26(30): 31384. CrossRef
- Replication of Early B-cell Factor 1 (EBF1) Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population
- Hyun-Jin Kim, Jin-Young Min, Kyoung-Bok Min
- J Prev Med Public Health. 2016;49(5):253-259. Published online July 10, 2016
- DOI: https://doi.org/10.3961/jpmph.16.028
- 9,847 View
- 157 Download
- 2 Crossref
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Abstract
PDF
- Objectives
Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity. Although several large-scale genome-wide association studies have reported susceptibility genes for central adiposity, the effects of interactions between genes and psychosocial stress on central adiposity have rarely been examined. A recent study focusing on Caucasians discovered the novel gene
Methods
A total of 1467 Korean adults were included in this study. We selected 22 single-nucleotide polymorphisms (SNPs) in the EBF1 gene and analyzed their interactions with stress on central adiposity using additive, dominant, and recessive genetic modeling.
Results
The four SNPs that had strong linkage disequilibrium relationships (rs10061900, rs10070743, rs4704967, and rs10056564) demonstrated significant interactions with the waist-hip ratio in the dominant model (pint<0.007). In addition, two other SNPs (rs6556377 and rs13180086) were associated with VAT by interactions with stress levels, especially in the recessive genetic model (pint<0.007). As stress levels increased, the mean values of central adiposity traits according to SNP genotypes exhibited gradual but significant changes (p<0.05).
Conclusions
These results suggest that the common genetic variants for EBF1 are associated with central adiposity through interactions with stress levels, emphasizing the importance of managing stress in the prevention of central obesity. -
Summary
Citations
Citations to this article as recorded byReviews- Gene-Diet Interaction on Cancer Risk in Epidemiological Studies.
- Sang Ah Lee
- J Prev Med Public Health. 2009;42(6):360-370.
- DOI: https://doi.org/10.3961/jpmph.2009.42.6.360
- 5,924 View
- 170 Download
- 15 Crossref
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Abstract
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- Genetic factors clearly play a role in carcinogenesis, but migrant studies provide unequivocal evidence that environmental factors are critical in defining cancer risk. Therefore, one may expect that the lower availability of substrate for biochemical reactions leads to more genetic changes in enzyme function; for example, most studies have indicated the variant MTHFR genotype 677TT is related to biomarkers, such as homocysteine concentrations or global DNA methylation particularly in a low folate diet. The modification of a phenotype related to a genotype, particularly by dietary habits, could support the notion that some of inconsistencies in findings from molecular epidemiologic studies could be due to differences in the populations studied and unaccounted underlying characteristics mediating the relationship between genetic polymorphisms and the actual phenotypes. Given the evidence that diet can modify cancer risk, gene-diet interactions in cancer etiology would be anticipated. However, much of the evidence in this area comes from observational epidemiology, which limits the causal inference. Thus, the investigation of these interactions is essential to gain a full understanding of the impact of genetic variation on health outcomes. This report reviews current approaches to gene-diet interactions in epidemiological studies. Characteristics of gene and dietary factors are divided into four categories: one carbon metabolism-related gene polymorphisms and dietary factors including folate, vitamin B group and methionines; oxidative stress-related gene polymorphisms and antioxidant nutrients including vegetable and fruit intake; carcinogen-metabolizing gene polymorphisms and meat intake including heterocyclic amins and polycyclic aromatic hydrocarbon; and other gene-diet interactive effect on cancer.
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Summary
Citations
Citations to this article as recorded by- Exploring the Interplay Between Vitamin B12-related Biomarkers, DNA Methylation, and Gene-Nutrition Interaction in Esophageal Precancerous Lesions
Da Pan, Ming Su, Dengfeng Xu, Yuanyuan Wang, Han Gao, James Daniel Smith, Jihan Sun, Xin Wang, Qingyang Yan, Guang Song, Yifei Lu, Wuqiong Feng, Shaokang Wang, Guiju Sun
Archives of Medical Research.2023; 54(7): 102889. CrossRef - Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies
Gemma Rodriguez-Carnero, Paula M. Lorenzo, Ana Canton-Blanco, Leire Mendizabal, Maddi Arregi, Mirella Zulueta, Laureano Simon, Manuel Macia-Cortiñas, Felipe F. Casanueva, Ana B. Crujeiras
Nutrients.2022; 14(13): 2702. CrossRef - Genetic Variants Shaping Inter-individual Differences in Response to Dietary Intakes—A Narrative Review of the Case of Vitamins
Aikaterini Niforou, Valentini Konstantinidou, Androniki Naska
Frontiers in Nutrition.2020;[Epub] CrossRef - Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
Tania Rescigno, Luigina Micolucci, Mario Tecce, Anna Capasso
Molecules.2017; 22(1): 105. CrossRef - Genetic polymorphisms and folate status
Mami Hiraoka, Yasuo Kagawa
Congenital Anomalies.2017; 57(5): 142. CrossRef - Methionine-supplemented diet affects the expression of cardiovascular disease-related genes and increases inflammatory cytokines in mice heart and liver
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Emma L. Beckett, Patrice R. Jones, Martin Veysey, Mark Lucock
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Maurizio Dattilo, D’Amato Giuseppe, Caroppo Ettore, Yves Ménézo
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Omer Kucuk
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Todd M. Gibson, Paul Brennan, Summer Han, Sara Karami, David Zaridze, Vladimir Janout, Helen Kollarova, Vladimir Bencko, Marie Navratilova, Neonila Szeszenia-Dabrowska, Dana Mates, Alena Slamova, Ruth M. Pfeiffer, Rachael Z. Stolzenberg-Solomon, Susan T.
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So-Hee Han, Kyoung-Mu Lee
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- Discovering Gene-Environment Interactions in the Post-Genomic Era.
- Nirinjini Naidoo, Kee Seng Chia
- J Prev Med Public Health. 2009;42(6):356-359.
- DOI: https://doi.org/10.3961/jpmph.2009.42.6.356
- 4,317 View
- 33 Download
- 1 Crossref
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Abstract
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- In the more than 100 genome wide association studies (GWAS) conducted in the past 5 years, more than 250 genetic loci contributing to more than 40 common diseases and traits have been identified. Whilst many genes have been linked to a trait, both their individual and combined effects are small and unable to explain earlier estimates of heritability. Given the rapid changes in disease incidence that cannot be accounted for by changes in diagnostic practises, there is need to have well characterized exposure information in addition to genomic data for the study of gene-environment interactions. The case-control and cohort study designs are most suited for studying associations between risk factors and occurrence of an outcome. However, the case control study design is subject to several biases and hence the preferred choice of the prospective cohort study design in investigating gene-environment interactions. A major limitation of utilising the prospective cohort study design is the long duration of follow-up of participants to accumulate adequate outcome data. The GWAS paradigm is a timely reminder for traditional epidemiologists who often perform one- or few-at-a-time hypothesis-testing studies with the main hallmarks of GWAS being the agnostic approach and the massive dataset derived through large-scale international collaborations.
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Summary
Citations
Citations to this article as recorded by- The Therapeutic Potential of Epigenetics in Autoimmune Diseases
Maria De Santis, Carlo Selmi
Clinical Reviews in Allergy & Immunology.2012; 42(1): 92. CrossRef
English Abstract- Statistical Issues in Genomic Cohort Studies.
- Sohee Park
- J Prev Med Public Health. 2007;40(2):108-113.
- DOI: https://doi.org/10.3961/jpmph.2007.40.2.108
- 3,237 View
- 26 Download
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Abstract
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- When conducting large-scale cohort studies, numerous statistical issues arise from the range of study design, data collection, data analysis and interpretation. In genomic cohort studies, these statistical problems become more complicated, which need to be carefully dealt with. Rapid technical advances in genomic studies produce enormous amount of data to be analyzed and traditional statistical methods are no longer sufficient to handle these data. In this paper, we reviewed several important statistical issues that occur frequently in large-scale genomic cohort studies, including measurement error and its relevant correction methods, cost-efficient design strategy for main cohort and validation studies, inflated Type I error, gene-gene and gene-environment interaction and time-varying hazard ratios. It is very important to employ appropriate statistical methods in order to make the best use of valuable cohort data and produce valid and reliable study results.
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SummaryOriginal Articles
- Different Effect of Blood Lead on Zinc Protoporphyrin by Gender in Korean Lead Workers.
- Hyun Cheol Ahn, Yong Bae Kim, Gap Soo Lee, Kyu Yoon Hwang, Sung Soo Lee, Kyu Dong Ahn, Byung Kook Lee
- Korean J Prev Med. 1999;32(4):499-504.
- 2,155 View
- 19 Download
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Abstract
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- OBJECTIVES
To evaluate whether a relation between blood lead and zinc proto porphyrin(ZPP) was modified by gender in Korean lead workers. METHODS: A cross-sectional study was conducted with 1,304 male and 101 female subjects in 1997. The relation between blood lead and ZPP were evaluated with linear, exponential, and quadratic models. Then, the different effect of gender on the relation was examined by adding the interaction terms in the each model. RESULTS: Mean+/-SD of blood lead and ZPP level was different between male(27.7+/-10 microgram /dl and 51.3+/-23.4 microgram/dl) and female subjects(22.5+/-9.2 microgram/dl and 78.7+/-38.6 microgram/dl). After adjusting for possible confounders, the effect modification by gender was significant in linear(beta=1.119, p<0.001), exponential(beta=Exp(0.008), p<0.05), and quadratic model(beta= 1.388, p<0.001). In separate analysis, a quadratic relation between blood lead and ZPP was shown in male lead workers(beta=0.036, p<0.001), but an exponential relation in female lead workers(n=Exp(0.029), p<0.001). CONCLUSION: Our data showed that the increasing rate of ZPP in female were always higher than in male lead workers, suggesting that females were more susceptible to occupational lead exposure than males. -
Summary
- The effects of aircraft noise on the hearing loss, blood pressure and response to psychological stress.
- Sang Hwan Han, Soo Hun Cho, Kyungshim Koh, Ho Jang Kwon, Mina Ha, Yeong Su Ju, Myung Hee Shin
- Korean J Prev Med. 1997;30(2):356-368.
- 2,002 View
- 29 Download
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Abstract
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- In effort to determine whether aircraft noise can have health effects such as hearing loss, hypertension and psychological stress, a total of 111 male professors and administrative officers working a college near a military airport in Korea(exposed group) and a total of 168 males and 112 females matched by age groups(control groups) were analyzed. Personal noise exposure and indoor and outdoor sound level of jet aircraft noise were measured at the exposed area. And pure tone, air conduction test and measurement of blood pressure were given to the exposed(males) and matched control groups(males and females). BEPSI(Brief Encounter Psychological Instrument) and psychological response to aircraft noise were examined for the exposed group. The noise dosimetry results revealed time-weighted averages(TWAs) that ranged from 61 to 68 dBA. However the levels encountered during taking off jet airplanes reached 126 dBA for two half minutes time period. The audiometric test showed that mean values of HTL(hearing threshold level) in exposed group at every frequency(500, 1,000, 2,000, 4,000, and 8,000 Hz were much lower than them of male and female control groups. And in old age groups, interaction of age and noise was observed at 8,000 Hz in both ears(p< 0.05). Conclusively, aircraft noise does not appear to induce hearing loss directly, but may decreased hearing threshold level by interaction of aging process and noise exposure. However, difference of mean values of exposed and control groups on blood pressure was not significantly. In psychological test, annoyance was the most severe psychological response to noise in exposed group, but mean value of BEPSI was not correlated with job duration in exposed group
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Summary
- The Effect of Job Stress and Social Support on the Organizational Effectiveness of Hospital Employees.
- Jong Wook Ko, Young Joon Seo, Ha Young Park
- Korean J Prev Med. 1996;29(2):295-308.
- 2,395 View
- 84 Download
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Abstract
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- The purpose of this study is to investigate the effect of job stress and social support on the organizational effectiveness of hospital employees and to examine the role of social support in the experience of job stress among the employees. Previous studies have yielded mixed results regarding the role of social support. Some studies provide supporting evidence for the buffering effect of social support, while others do not. Still others report findings about reverse buffering effects. These inconsistent findings are, in part, accounted for by methodological problems such as poor measurement, small sample size, and the existence of high multicollinearity. To examine more rigorously the role of social support in relation to the negative effects of job stress, this study was carefully designed to overcome methodolgical shortcomings found in the past research. In addition, unlike the previous studies, which were concerned mostly with health-related variables as consequences of job stress, in this study, three work-related variables (job satisfaction, organizational commitment, and intent to stay) which had close relationships with organizational effectiveness were examined as output variables. The sample used in this study consisted of 353 employees from a university hospital in the suburbs of seoul. Data were collected with self-administered questionnaires and analyzed using canonical analysis and hierarchical regression analysis. The results of this study indicate that; (l) job stress has negative main effects on job satisfaction, organizational commitment, and intent to stay; (2) social support has positive main effects on the same three output variables, (3) social support does not moderate the harmful effects of job stress on the three outcome variables, and (4) the three-way interaction effects of (social support * job stress * gender) and of (social support * job stress * education) are not supported The implications of these findings for the management of human resources are discussed.
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