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Original Articles
- Comparison of Computed Tomography-based Abdominal Adiposity Indexes as Predictors of Non-alcoholic Fatty Liver Disease Among Middle-aged Korean Men and Women
- Jongmin Baek, Sun Jae Jung, Jee-Seon Shim, Yong Woo Jeon, Eunsun Seo, Hyeon Chang Kim
- J Prev Med Public Health. 2020;53(4):256-265. Published online June 18, 2020
- DOI: https://doi.org/10.3961/jpmph.20.140
- 4,838 View
- 163 Download
- 3 Crossref
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Abstract
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Supplementary Material - Objectives
We compared the associations of 3 computed tomography (CT)-based abdominal adiposity indexes with non-alcoholic fatty liver disease (NAFLD) among middle-aged Korean men and women.
Methods
The participants were 1366 men and 2480 women community-dwellers aged 30-64 years. Three abdominal adiposity indexes—visceral fat area (VFA), subcutaneous fat area (SFA), and visceral-to-subcutaneous fat ratio (VSR)—were calculated from abdominal CT scans. NAFLD was determined by calculating the Liver Fat Score from comorbidities and blood tests. An NAFLD prediction model that included waist circumference (WC) as a measure of abdominal adiposity was designated as the base model, to which VFA, SFA, and VSR were added in turn. The area under the receiver operating characteristic curve (AUC), integrated discrimination improvement (IDI), and net reclassification improvement (NRI) were calculated to quantify the additional predictive value of VFA, SFA, and VSR relative to WC.
Results
VFA and VSR were positively associated with NAFLD in both genders. SFA was not significantly associated with NAFLD in men, but it was negatively associated in women. When VFA, SFA, and VSR were added to the WC-based NAFLD prediction model, the AUC improved by 0.013 (p<0.001), 0.001 (p=0.434), and 0.009 (p=0.007) in men and by 0.044 (p<0.001), 0.017 (p<0.001), and 0.046 (p<0.001) in women, respectively. The IDI and NRI were increased the most by VFA in men and VSR in women.
Conclusions
Using CT-based abdominal adiposity indexes in addition to WC may improve the detection of NAFLD. The best predictive indicators were VFA in men and VSR in women. -
Summary
Citations
Citations to this article as recorded by
- Relationship between Non-Alcoholic Fatty Liver Disease and Visceral Fat Measured by Imaging-Based Body Composition Analysis: A Systematic Review
Ker Ming Seaw, Christiani Jeyakumar Henry, Xinyan Bi
Livers.2023; 3(3): 463. CrossRef - Stratifying the risk of ovarian cancer incidence by histologic subtypes in the Korean Epithelial Ovarian Cancer Study (Ko‐EVE)
Soseul Sung, Youjin Hong, Byoung‐Gie Kim, Ji‐Yeob Choi, Jae Weon Kim, Sang‐Yoon Park, Jae‐Hoon Kim, Yong‐man Kim, Jong‐Min Lee, Tae Jin Kim, Sue K. Park
Cancer Medicine.2023; 12(7): 8742. CrossRef - Correlation between CT Abdominal Anthropometric Measurements and Liver Density in Individuals with Non-Alcoholic Fatty Liver Disease
Dragoș Constantin Cucoranu, Marian Pop, Raluca Niculescu, Vlad Vunvulea, Irina-Bianca Kosovski, Radu-Ovidiu Togănel, Eliza Russu, Adrian Vasile Mureșan, Răzvan-Andrei Licu, Anca Bacârea
Medicina.2023; 59(3): 500. CrossRef
- Smoking Is Associated With Abdominal Obesity, Not Overall Obesity, in Men With Type 2 Diabetes
- Ji Eun Yun, Heejin Kimm, Young Ju Choi, Sun Ha Jee, Kap Bum Huh
- J Prev Med Public Health. 2012;45(5):316-322. Published online September 28, 2012
- DOI: https://doi.org/10.3961/jpmph.2012.45.5.316
- 9,188 View
- 98 Download
- 16 Crossref
-
Abstract
PDF
Objectives Abdominal obesity increases mortality and morbidity from cardiovascular disease and there is a possibility that smoking effects obesity. However, previous studies concerning the effects of smoking on obesity are inconsistent. The objective of this study was to examine whether smoking is positively related to abdominal obesity in men with type 2 diabetes.
Methods Subjects consisted of 2197 type 2 diabetic patients who visited Huh's Diabetes Center from 2003 to 2009. Indices of abdominal obesity were defined as visceral fat thickness (VFT) measured by ultrasonography and waist circumference (WC). Overall obesity was defined as body mass index (BMI).
Results Statistically significant differences in WC and VFT by smoking status were identified. However, there was no statistical difference in BMI according to smoking status. Means of WC and VFT were not significantly higher in heavy smokers and lower in mild smokers. Compared to nonsmokers, the BMI confounder adjusted odds ratio and 95% confidence interval for VFT in ex-smokers and current-smokers were 1.70 (1.21 to 2.39) and 1.86 (1.27 to 2.73), respectively.
Conclusions Smoking status was positively associated with abdominal obesity in type 2 diabetic patients.
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Summary
Citations
Citations to this article as recorded by- Nutritional status of people who inject drugs in Coastal Kenya: a cross-sectional study
Valentine Budambula, Moses Ngari, Nancy L.M. Budambula, Aabid A. Ahmed, Tom Were
BMC Nutrition.2024;[Epub] CrossRef - Smoking and cardiovascular disease in patients with type 2 diabetes: a prospective observational study
Peder af Geijerstam, Fredrik Janryd, Fredrik H. Nyström
Journal of Cardiovascular Medicine.2023; 24(11): 802. CrossRef - Prevalence and Predictors of Combined Body Mass Index and Waist Circumference Among Indian Adults
Neha Shri, Saurabh Singh, Akancha Singh
International Journal of Public Health.2023;[Epub] CrossRef - Prevalence and related factors of abdominal obesity among urban adults aged 35 to 79 years in southwest China
Chuan Huang, Ying Zhang, Ya Liu, Jian-Xiong Liu, Yong-Mei Hu, Wei-Wei Tang, Tzung-Dau Wang, Xiao-bo Huang
Frontiers in Public Health.2023;[Epub] CrossRef - Exploring the Impact of the Obesity Paradox on Lung Cancer and Other Malignancies
Lindsay Joyce Nitsche, Sarbajit Mukherjee, Kareena Cheruvu, Cathleen Krabak, Rohit Rachala, Kalyan Ratnakaram, Priyanka Sharma, Maddy Singh, Sai Yendamuri
Cancers.2022; 14(6): 1440. CrossRef - Long-Term Adverse Effects of Cigarette Smoking on the Incidence Risk of Metabolic Syndrome With a Dose-Response Relationship: Longitudinal Findings of the Korean Genome and Epidemiology Study Over 12 Years
Ae Hee Kim, In-Ho Seo, Hye Sun Lee, Yong-Jae Lee
Endocrine Practice.2022; 28(6): 603. CrossRef - Sex-Dependent Effects of Inhaled Nicotine on the Gut Microbiome
Anna K Whitehead, Margaret C Meyers, Christopher M Taylor, Meng Luo, Scot E Dowd, Xinping Yue, Lauri O Byerley
Nicotine & Tobacco Research.2022; 24(9): 1363. CrossRef - Determinants of Metabolic Health Across Body Mass Index Categories in Central Europe: A Comparison Between Swiss and Czech Populations
Sarka Kunzova, Andrea Maugeri, Jose Medina-Inojosa, Francisco Lopez-Jimenez, Manlio Vinciguerra, Pedro Marques-Vidal
Frontiers in Public Health.2020;[Epub] CrossRef - From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research
Radia Khan, Zoey Chua, Jia Tan, Yingying Yang, Zehuan Liao, Yan Zhao
Medicina.2019; 55(9): 546. CrossRef - Cigarette Smoking Is Negatively Associated with the Prevalence of Type 2 Diabetes in Middle-Aged Men with Normal Weight but Positively Associated with Stroke in Men
Su Wang, Jie Chen, Yuzhong Wang, Yu Yang, Danyu Zhang, Chao Liu, Kun Wang
Journal of Diabetes Research.2019; 2019: 1. CrossRef - Forecasting obesity prevalence in Korean adults for the years 2020 and 2030 by the analysis of contributing factors
Inkyung Baik
Nutrition Research and Practice.2018; 12(3): 251. CrossRef - Obesity in Older Type 2 Diabetic Patients: Does Working Environment Add Vulnerability?
Maria Brandão, Margarida Cardoso
International Journal of Environmental Research and Public Health.2018; 15(12): 2677. CrossRef - Smoking and the risk of type 2 diabetes
Judith Maddatu, Emily Anderson-Baucum, Carmella Evans-Molina
Translational Research.2017; 184: 101. CrossRef - Metabolic effects of smoking cessation
Kindred K. Harris, Mohan Zopey, Theodore C. Friedman
Nature Reviews Endocrinology.2016; 12(5): 299. CrossRef - Smoking status and abdominal obesity among normal- and overweight/obese adults: Population-based FINRISK study
Eeva-Liisa Tuovinen, Suoma E. Saarni, Satu Männistö, Katja Borodulin, Kristiina Patja, Taru H. Kinnunen, Jaakko Kaprio, Tellervo Korhonen
Preventive Medicine Reports.2016; 4: 324. CrossRef - Joint Association of Nicotinic Acetylcholine Receptor Variants with Abdominal Obesity in American Indians: The Strong Heart Family Study
Yun Zhu, Jingyun Yang, Fawn Yeh, Shelley A. Cole, Karin Haack, Elisa T. Lee, Barbara V. Howard, Jinying Zhao, Mohammed Akaaboune
PLoS ONE.2014; 9(7): e102220. CrossRef
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