Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health


Author index

Page Path
HOME > Browse Articles > Author index
Beyoung Yun Park 1 Article
Differential Parental Transmission of Markers in BCL3 among Korean Cleft Case-parent Trios.
Beyoung Yun Park, Jae Woong Sull, Jung Yong Park, Sun Ha Jee, Terri H Beaty
J Prev Med Public Health. 2009;42(1):1-4.
  • 4,702 View
  • 48 Download
  • 14 Crossref
AbstractAbstract PDF
Isolated cleft lip with or without cleft palate (CL/P) is among the most common human birth defects, with a prevalence of approximately 1 in 700 live births. The B-Cell Leukemia/lymphoma 3 (BCL3) gene has been suggested as a candidate gene for CL/P based on association and linkage studies in some populations. This study tests for an association between markers in BCL3 and isolated, non-syndromic CL/P using a case-parent trio design, while considering parent-of-origin effects. METHODS: Forty case-parent trios were genotyped for two single nucleotide polymorphisms (SNPs) in the BCL3 gene. We performed a transmission disequilibrium test (TDT) on individual SNPs, and the FAMHAP package was used to estimate haplotype frequencies and to test for excess transmission of multi-SNP haplotypes. RESULTS: The odds ratio for transmission of the minor allele, OR (transmission), was significant for SNP rs8100239 (OR=3.50, p=0.004) and rs2965169 (OR=2.08, p=0.027) when parent-of-origin was not considered. Parent-specific TDT revealed that SNP rs8100239 showed excess maternal transmission. Analysis of haplotypes of rs2965169 and rs8100239 also suggested excess maternal transmission. CONCLUSIONS: BCL3 appears to influence risk of CL/P through a parent-of-origin effect with excess maternal transmission.


Citations to this article as recorded by  
  • Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P)
    Lord J. J. Gowans, Carissa L. Comnick, Peter A. Mossey, Mekonen A. Eshete, Wasiu L. Adeyemo, Thirona Naicker, Waheed A. Awotoye, Aline Petrin, Chinyere Adeleke, Peter Donkor, Tamara D. Busch, Olutayo James, Mobolanle O. Ogunlewe, Mary Li, Joy Olotu, Mohan
    The Cleft Palate-Craniofacial Journal.2022; 59(7): 841.     CrossRef
  • Association of nucleotide variants of GRHL3, IRF6, NAT2, SDC2, BCL3, and PVRL1 genes with nonsyndromic cleft lip with/without cleft palate in multigenerational families: A retrospective study
    PraveenKumar Neela, SrinivasReddy Gosla, Akhter Husain, Vasavi Mohan, Sravya Thumoju, BV Rajeshwari
    Contemporary Clinical Dentistry.2021; 12(2): 138.     CrossRef
  • Genetic Factors in Nonsyndromic Orofacial Clefts
    Mahamad Irfanulla Khan, Prashanth CS, Narasimha Murthy Srinath
    Global Medical Genetics.2020; 07(04): 101.     CrossRef
  • An integrated genomic-transcriptomic approach supports a role for the proto-oncogene BCL3 in atherosclerosis
    Giovanna Marchetti, Domenico Girelli, Carlotta Zerbinati, Barbara Lunghi, Simonetta Friso, Silvia Meneghetti, Matteo Coen, Teresa Gagliano, Giuseppe Guastella, Marie-Luce Bochaton-Piallat, Francesca Pizzolo, Francesco Mascoli, Giovanni Malerba, Matteo Bov
    Thrombosis and Haemostasis.2015; 113(03): 655.     CrossRef
  • Genomic expression in non syndromic cleft lip and palate patients: A review
    D. Mehrotra
    Journal of Oral Biology and Craniofacial Research.2015; 5(2): 86.     CrossRef
  • Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients
    Foteinos-Ioannis D. Dimitrakopoulos, Anna G. Antonacopoulou, Anastasia Kottorou, Stella Marousi, Ioulia Koukourikou, Melpomeni Kalofonou, Nikolaos Panagopoulos, Chrisoula Scopa, Dimitrios Dougenis, Helen Papadaki, Athanasios G. Papavassiliou, Haralabos P.
    Lung Cancer.2015; 89(3): 311.     CrossRef
  • Genetic risk factors for orofacial clefts in Central Africans and Southeast Asians
    Jane C. Figueiredo, Stephanie Ly, Haley Raimondi, Kathy Magee, James W. Baurley, Pedro A. Sanchez‐Lara, Ugonna Ihenacho, Caroline Yao, Christopher K. Edlund, David van den Berg, Graham Casey, Yves A. DeClerk, Jonathan M. Samet, William Magee
    American Journal of Medical Genetics Part A.2014; 164(10): 2572.     CrossRef
  • Genome‐wide approaches (GWA) in oral and craniofacial diseases research
    H Kim, S Gordon, R Dionne
    Oral Diseases.2013; 19(2): 111.     CrossRef
  • Male and female differential reproductive rate could explain parental transmission asymmetry of mutation origin in Hirschsprung disease
    Anne-Sophie Jannot, Jeanne Amiel, Anna Pelet, Francesca Lantieri, Raquel M Fernandez, Joke B G M Verheij, Merce Garcia-Barcelo, Stacey Arnold, Isabella Ceccherini, Salud Borrego, Robert M W Hofstra, Paul K H Tam, Arnold Munnich, Aravinda Chakravarti, Fran
    European Journal of Human Genetics.2012; 20(9): 917.     CrossRef
  • Gene Expression Changes in C57BL/6J and DBA/2J Mice Following Prenatal Alcohol Exposure
    Chris Downing, Stephen Flink, Maria L. Florez‐McClure, Thomas E. Johnson, Boris Tabakoff, Katerina J. Kechris
    Alcoholism: Clinical and Experimental Research.2012; 36(9): 1519.     CrossRef
  • BCL3 gene role in facial morphology
    Baiba Lace, Inga Kempa, Janis Klovins, Janis Stavusis, Astrida Krumina, Ilze Akota, Biruta Barkane, Alexandre R. Vieira, Erika Nagle, Ieva Grinfelde, Ieva Maulina
    Birth Defects Research Part A: Clinical and Molecular Teratology.2012; 94(11): 918.     CrossRef
  • Microdeletion of Chromosome 15q24.3–25.2 and Orofacial Clefting
    Bindya Sing, Dongli Song, Glenn Desandre, Balaji Govindaswami, Scott Rosenthal, Shelly Gunn, Robert Wallerstein
    The Cleft Palate-Craniofacial Journal.2011; 48(5): 596.     CrossRef
  • MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate
    Triin Jagomägi, Tiit Nikopensius, Kaarel Krjutškov, Veronika Tammekivi, Triin Viltrop, Mare Saag, Andres Metspalu
    European Journal of Oral Sciences.2010; 118(3): 213.     CrossRef
  • Parent‐of‐origin effects for MSX1 in a Chilean population with nonsyndromic cleft lip/palate
    José Suazo, José Luis Santos, Lilian Jara, Rafael Blanco
    American Journal of Medical Genetics Part A.2010; 152A(8): 2011.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health