Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health


Author index

Page Path
HOME > Browse Articles > Author index
Dimitrios T. Papadimitriou 1 Article
The Big Vitamin D Mistake
Dimitrios T. Papadimitriou
J Prev Med Public Health. 2017;50(4):278-281.   Published online May 10, 2017
  • 54,826 View
  • 1,051 Download
  • 28 Crossref
AbstractAbstract PDF
Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities’ decision to fortify dietary milk products with cholecalciferol. The role of vitamin D in innate and adaptive immunity is critical. A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L. Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L and 9122 IU/d was needed to reach 100 nmol/L. The largest meta-analysis ever conducted of studies published between 1966 and 2013 showed that 25-hydroxyvitamin D levels <75 nmol/L may be too low for safety and associated with higher all-cause mortality, demolishing the previously presumed U-shape curve of mortality associated with vitamin D levels. Since all-disease mortality is reduced to 1.0 with serum vitamin D levels ≥100 nmol/L, we call public health authorities to consider designating as the RDA at least three-fourths of the levels proposed by the Endocrine Society Expert Committee as safe upper tolerable daily intake doses. This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency.


Citations to this article as recorded by  
  • Prevalence and determinants of insufficient vitamin D status in young Canadian Inuit children from Nunavik
    Huguette Turgeon O’Brien, Doris Gagné, Rosanne Blanchet, Carole Vézina
    Nutrition and Health.2024;[Epub]     CrossRef
  • Common Nutritional Shortcomings in Vegetarians and Vegans
    Joshua Gibbs, Francesco P. Cappuccio
    Dietetics.2024; 3(2): 114.     CrossRef
  • The Power of Vitamin D: Is the Future in Precision Nutrition through Personalized Supplementation Plans?
    Mladen Mavar, Tamara Sorić, Ena Bagarić, Ana Sarić, Marijana Matek Sarić
    Nutrients.2024; 16(8): 1176.     CrossRef
  • Impact of vitamin D on ultraviolet-induced photoaging and skin diseases
    Sankalya S. Ambagaspitiya, Gayan A. Appuhamillage, Rohan S. Dassanayake
    Exploration of Medicine.2024; : 363.     CrossRef
  • Serum vitamin D and cardiometabolic risk factors in the UK population
    Linia Patel, Carlo La Vecchia, Gianfranco Alicandro
    Journal of Human Nutrition and Dietetics.2023; 36(3): 1019.     CrossRef
  • A Narrative Review on the Potential Role of Vitamin D3 in the Prevention, Protection, and Disease Mitigation of Acute and Long COVID-19
    Meis Moukayed
    Current Nutrition Reports.2023; 12(2): 215.     CrossRef
  • Mushrooms as Functional Foods for Ménière’s Disease
    Victoria Bell, Tito Horácio Fernandes
    Applied Sciences.2023; 13(22): 12348.     CrossRef
  • Intense Testing and Use of Vitamin D Supplements Leads to Slow Improvement in Vitamin D Adequacy Rates: A Cross-Sectional Analysis of Real-World Data
    Rodis D. Paparodis, Dimitra Bantouna, Evangelos Karvounis, Ioannis Zoupas, Sarantis Livadas, Nicholas Angelopoulos, Shahnawaz Imam, Dimitrios T. Papadimitriou, Juan C. Jaume
    Nutrients.2023; 16(1): 111.     CrossRef
  • Role of vitamin D deficiency and comorbidities in COVID-19
    Gabriela Gama Freire Alberca, Ricardo Wesley Alberca
    World Journal of Virology.2022; 11(1): 85.     CrossRef
  • Rifampicin for COVID-19
    George D Panayiotakopoulos, Dimitrios T Papadimitriou
    World Journal of Virology.2022; 11(2): 90.     CrossRef
  • Perspective: Darwinian Applications to Nutrition—The Value of Evolutionary Insights to Teachers and Students
    Eirik Garnås
    Advances in Nutrition.2022; 13(5): 1431.     CrossRef
  • Latent toxoplasmosis and vitamin D concentration in humans: three observational studies
    Sarka Kankova, Marie Bicikova, Ludmila Macova, Jana Hlavacova, Katerina Sykorova, Dobroslava Jandova, Jaroslav Flegr
    Folia Parasitologica.2021;[Epub]     CrossRef
  • The role of vitamin D in reducing SARS-CoV-2 infection: An update
    Mohammad Shah Alam, Daniel M. Czajkowsky, Md. Aminul Islam, Md. Ataur Rahman
    International Immunopharmacology.2021; 97: 107686.     CrossRef
  • Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach
    Dimitrios T Papadimitriou, Alexandros K Vassaras, Michael F Holick
    World Journal of Virology.2021; 10(3): 111.     CrossRef
  • Serum iPTH range in a reference population: From an integrated approach to vitamin D prevalence impact evaluation
    Marilena Minieri, Bruno Daniele Leoni, Lorenza Bellincampi, Daniela Bajo, Alessia Agnoli, Anna Maria De Angelis, Massimo Pieri, Francesco Equitani, Vincenzo Rossi, Filippa Valente, Stefano Pignalosa, Alessandro Terrinoni, Sergio Bernardini
    Clinica Chimica Acta.2021; 521: 1.     CrossRef
  • The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study
    Anca Andreea Boboc, Carmen Nicoleta Novac, Maria Teodora Ilie, Mara Ioana Ieșanu, Felicia Galoș, Mihaela Bălgrădean, Elena Camelia Berghea, Marcela Daniela Ionescu
    Journal of Personalized Medicine.2021; 11(6): 551.     CrossRef
  • COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis
    Lorenz Borsche, Bernd Glauner, Julian von Mendel
    Nutrients.2021; 13(10): 3596.     CrossRef
  • Co-administration of vitamin D3 and Lacticaseibacillus paracasei DG increase 25-hydroxyvitamin D serum levels in mice
    Ignazio Castagliuolo, Melania Scarpa, Paola Brun, Giulia Bernabe, Valeria Sagheddu, Marina Elli, Walter Fiore, Valerio De Vitis, Simone Guglielmetti
    Annals of Microbiology.2021;[Epub]     CrossRef
  • Association between Vitamin D Supplementation and Mental Health in Healthy Adults: A Systematic Review
    Dominika Guzek, Aleksandra Kołota, Katarzyna Lachowicz, Dominika Skolmowska, Małgorzata Stachoń, Dominika Głąbska
    Journal of Clinical Medicine.2021; 10(21): 5156.     CrossRef
  • Relationship between plasma levels of 25-hydroxyvitamin D and arterial stiffness in elderly Chinese with non-dipper hypertension
    Jian-Wei Gu, Ju-Hua Liu, Hui-Neng Xiao, Yun-Feng Yang, Wen-Ju Dong, Quan-Bo Zhang, Li Liu, Cheng-Shi He, Bi-Hua Wu
    Medicine.2020; 99(7): e19200.     CrossRef
  • Sunlight and health: shifting the focus from vitamin D3 to photobiomodulation by red and near-infrared light
    Vladimir Heiskanen, Morgan Pfiffner, Timo Partonen
    Ageing Research Reviews.2020; 61: 101089.     CrossRef
  • Effects of circulating vitamin D concentrations on emotion, behavior and attention: A cross-sectional study in preschool children with follow-up behavior experiments in juvenile mice
    Xirui Wang, Xianting Jiao, Mingqing Xu, Bin Wang, Juan Li, Fan Yang, Lishan Zhang, Lei Xu, Xiaodan Yu
    Journal of Affective Disorders.2020; 275: 290.     CrossRef
  • The role of vitamin D in seasonal acute respiratory viral infections and COVID-19
    E. A. Pigarova, A. A. Povalyaeva, L. K. Dzeranova, L. Y. Rozhinskaya, N. G. Mokrysheva
    Terapevticheskii arkhiv.2020; 92(11): 98.     CrossRef
  • Pediatric natural health products recommended by chiropractic and naturopathic doctors in Canada
    Antony Joseph Porcino, Leslie Solomonian, Stephen Zylich, Chantal Doucet, Brian Gluvic, Sunita Vohra
    Complementary Therapies in Medicine.2019; 43: 196.     CrossRef
  • Skin fairness is a better predictor for impaired physical and mental health than hair redness
    Jaroslav Flegr, Kateřina Sýkorová
    Scientific Reports.2019;[Epub]     CrossRef
  • Prevalence of hypovitaminosis D, and its association with hypoadiponectinemia and hyperfollistatinemia, in Saudi women with naïve polycystic ovary syndrome
    Osama Adnan Kensara
    Journal of Clinical & Translational Endocrinology.2018; 12: 20.     CrossRef
  • Role of nutritional vitamin D in osteoporosis treatment
    Yi-Chou Hou, Chia-Chao Wu, Min-Tser Liao, Jia-Fwu Shyu, Chi-Feng Hung, Tzung-Hai Yen, Chien-Lin Lu, Kuo-Cheng Lu
    Clinica Chimica Acta.2018; 484: 179.     CrossRef
  • Successful Treatment of Severe Atopic Dermatitis with Calcitriol and Paricalcitol in an 8-Year-Old Girl
    Christina Bothou, Alexis Alexopoulos, Eleni Dermitzaki, Kleanthis Kleanthous, Anastasios Papadimitriou, George Mastorakos, Dimitrios T. Papadimitriou
    Case Reports in Pediatrics.2018; 2018: 1.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health