- The Association Between Apolipoprotein E Genotype and Lipid Profiles in Healthy Woman Workers.
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Kieun Moon, Sook Hee Sung, Youn Koun Chang, Il Keun Park, Yun Mi Paek, Soo Geun Kim, Tae In Choi, Young Woo Jin
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J Prev Med Public Health. 2010;43(3):213-221.
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DOI: https://doi.org/10.3961/jpmph.2010.43.3.213
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 Abstract
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- OBJECTIVES
Plasma lipid profiles and Apolipoprotein E (ApoE) are established risk factors for cardiovascular disease (CVD). The knowledge of lipid profile may estimate the potential victims of cardiovascular disease before its initiation and progression and offers the opportunity for primary prevention. The most common ApoE polymorphism has been found to influence plasma lipid concentrations and its correlation with CVD has been extensively investigated in the last decade. METHODS: The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. The information on confounding factors was obtained through a self-administered questionnaire and ApoE polymorphism was investigated using PCR. RESULTS: The relative frequencies of alleles E2, E3 and E4 for the study population (n=305) were 0.127, 0.750 and 0.121, respectively. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile. In order to estimate the independent effects of alleles E2 and E4, as compared with E3, on lipid profile, multiple regression was performed after adjustment for confounding variables such as age, BMI, blood pressure, education status, insulin, fasting glucose, HOMA-IR, menopause. ApoE2 had a negative association with HDL cholesterol and ApoE4 had a positive association with LDL cholesterol. CONCLUSIONS: This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.
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Citations
Citations to this article as recorded by  - Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis
Sung Ryul Yu, Kyung-A Shin
Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 495. CrossRef - Association between Hypertriglyceridemic-Waist Phenotype and Metabolic Abnormalities in Hypertensive Adults
Kyung-A SHIN, Myung Shin KANG
Korean Journal of Clinical Laboratory Science.2023; 55(2): 113. CrossRef - Association Between Four Anthropometric Indexes and Metabolic Syndrome in US Adults
Yaling Li, Rui Zheng, Shuting Li, Ruyi Cai, Feihua Ni, Huiyan Zheng, Ruying Hu, Ting Sun
Frontiers in Endocrinology.2022;[Epub] CrossRef - Shared genetic risk factors for depression and stroke
Fuying Zhao, Yingying Yue, Haitang Jiang, Yonggui Yuan
Progress in Neuro-Psychopharmacology and Biological Psychiatry.2019; 93: 55. CrossRef - Assessing a Body Shape Index and Waist to Height Ratio as a Risk Predictor for Insulin Resistance and Metabolic Syndrome among Korean Adults
Kyung-A Shin
The Korean Journal of Clinical Laboratory Science.2018; 50(1): 44. CrossRef - Clinical Usefulness of Serum Uric Acid and Resting Heart Rate in the Diagnosis of Metabolic Syndrome in Korean Adults
Kyung-A Shin
Biomedical Science Letters.2017; 23(2): 118. CrossRef - The Association of Pulse Pressure and Pre-Metabolic Syndrome in Korean Middle Aged Men
Kyung-A Shin
Biomedical Science Letters.2017; 23(2): 73. CrossRef - The Clinical Implications of Hepatic Enzymes in Metabolically Healthy Obese Men
Kyung-A Shin
The Korean Journal of Clinical Laboratory Science.2017; 49(3): 248. CrossRef - Relationship between the Lipid Accumulation Product Index and Alanine Aminotransferase in Korean Adult Men
Kyung-A Shin
The Korean Journal of Clinical Laboratory Science.2017; 49(4): 374. CrossRef - The Differences of Metabolic Syndrome Risk Factors according to Obesity and Abdominal Obesity in Elderly Korean Women
Kyung-A Shin
The Korean Journal of Clinical Laboratory Science.2016; 48(4): 304. CrossRef
- The Incidence and Risk Factors of Hypertension that Developed in a Male-workers' Cohort for 3 Years.
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Hyun Ju Seo, Soo Geun Kim, Chong Soon Kim, Yun Kyun Chang, Il Geun Park
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J Prev Med Public Health. 2006;39(3):229-234.
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Abstract
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- OBJECTIVES
Cardiovascular disease is one of the main causes of death and morbidity in Korea. In this study, the prevalence and incidence of developing hypertension in a male-workers' cohort were investigated during 3-years follow-up with a view to find the risk factors that affected the development of hypertension. METHODS: Among the 5,374 people who participated in a routine health check up, 3,852 people with normal blood pressure and who had no history of hypertension were prospectively followed up for 3 years. The classification of hypertension was based on the JNC7 report (the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure). Life style factors and underlying diseases that were related to the risk factors of hypertension were collected by using a self-report questionnaires via the internet. RESULTS: The prevalence of hypertension was 28.3% (1,520/5,374) at the first screening (2001). It was found that the incidence in 2004 of hypertension for the follow-up subjects (3,711) who had normal blood pressure in 2001 was 7.6 per 100 person-year. Multiple logistic regression analysis of the variables related to the risk factors of hypertension was carried out. The relative risks were 1.037 (95% CI=1.022-1.053) as the age increased 1 year and 1.039 (95% CI=1.023-1.055) as the body mass index increased 1 kg/m2. The relative risk for the prehypertensive group was 2.501(95% CI=1.986-3.149) compared to the normotensive group. These results showed that age, body mass index and the baseline blood pressure were significantly related to the incidence of hypertension. CONCLUSIONS: The incidence of hypertension was 7.6 per 100 person-year during follow-up. It was concluded that the risk factors for developing hypertension in the short-term were age, BMI, and prehypertension; Especially, this showed that it is necessary for prehypertensives to manage their body weight and blood pressure to prevent hypertension in middle-age by modifying their life style.
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