Hepatitis C infection is responsible for high morbidity and mortality rates globally as well as for significant indirect costs. The disease burden caused by the hepatitis C virus (HCV) is comparable to the one caused by human immunodeficiency virus or tuberculosis. Today, simple detection methods, highly effective and easy to administer therapies and efficient preventative measures are available to combat hepatitis C. Nevertheless, in most countries around the world, the World Health Organization target of eliminating this infectious disease and its consequences by 2030 are not being met. Significant gaps in care for hepatitis C sufferers still exist, the shortcomings ranging from education and treatment to aftercare. Hepatitis C infection was and still is not on the radar of most politicians and health authorities. National programmes and strategies to combat the disease exist or are being developed in many countries. However, for these to be implemented efficiently and successfully, clear political commitment, strong civil society actors, well-functioning public health structures and the relevant support from global donors are needed.
Summary
Citations
Citations to this article as recorded by
Time to Hepatitis C Care Engagement and Treatment Outcomes in Canadian Immigrants Have Markedly Improved Over Three Decades Sabrina Fan, Haris Imsirovic, Gary Garber, Erin Kelly, Curtis Cooper Journal of Viral Hepatitis.2026;[Epub] CrossRef
Economic evaluations of the primary prevention programs for viral hepatitis-related liver disease and liver cancer: a systematic literature review Milena Lewandowska, Shenghan Cai, Shalini Wijekulasuriya, Putu Novi Arfirsta Dharmayani, Ann Carrigan, Stephen Goodall, Rose Boutros, Jacob George, Amany Zekry, Yvonne Zurynski Cost Effectiveness and Resource Allocation.2026;[Epub] CrossRef
Mortality trends of comorbid viral hepatitis C and psychoactive substance use disorders in the United States: Insights from CDC WONDER, 1999–2023 Masira Fatima, Meraal Faisal, Warda Fatima Shafee, Mahveen Iqbal, Maliha Iqbal, Nawaal Furqan, Muddassir Khalid, Umaima Ali Usmani, Sumia Fatima, Rida Noor Medicine.2026; 105(26): e49421. CrossRef
Prediction of ICU length of stay, hospital discharge outcomes and discharge location among ICU-admitted patients diagnosed with viral hepatitis using machine learning: a retrospective cohort study of the MIMIC-IV database Dimple Sushma Alluri, Felix M Pabon-Rodriguez BMJ Open.2026; 16(6): e106819. CrossRef
Impacts of hepatitis B and C prevention programmes on long-term outcomes of advanced liver disease and hepatocellular carcinoma: A systematic review Shenghan Cai, Putu Novi Arfirsta Dharmayani, Milena Lewandowska, Shalini Wijekulasuriya, Gifty Varghese, Ann Carrigan, Maryam Vizheh, Rose Boutros, Stephen Goodall, Jacob George, Amany Zekry, Yvonne Zurynski Public Health.2026; 258: 106384. CrossRef
Hepatitis C Treatment Outcomes Among Immigrants: A CANUHC Cohort Analysis Haris Imsirovic, Sabrina Fan, Gisela Macphail, Duncan Webster, Daniel Smyth, Sergio Borgia, Jordan J Feld, Sam Lee, Curtis L Cooper Open Forum Infectious Diseases.2026;[Epub] CrossRef
Reducing health inequalities for marginalised populations by improving access to hepatitis C virus testing and treatment Eugenia Lindile Moyo-Hlahla Primary Health Care.2025; 35(4): 22. CrossRef
The Global Burden of Cirrhosis and Other Chronic Liver Diseases in 2021 Ethan Kai Jun Tham, Darren Jun Hao Tan, Pojsakorn Danpanichkul, Cheng Han Ng, Nicholas Syn, Benjamin Koh, Ryan Yan Zhe Lim, Karn Wijarnpreecha, Magaret Li Peng Teng, Benjamin Kai Yi Nah, Benedix Kuan Loo Sim, Xianda Cheng, Zixuan Zhang, Kartik Mitra, Toru Liver International.2025;[Epub] CrossRef
Integrative immunoinformatics and molecular simulation-based design of a multi-epitope vaccine against hepatitis C virus Dharmendrasinh F. Rao, Taral Patel, Saumya K. Patel, Himanshu A. Pandya In Silico Research in Biomedicine.2025; 1: 100029. CrossRef
Hepatitis C—Everything a Primary Care Physician Needs to Know About Diagnosis, Management, and Follow-Up Sindhuri Benjaram, Shweta Kapur, Anusha McKay, Mohamad Khaled Almujarkesh, Kassandra S. Carter, Alexandra Picardal, Diane Levine, Prateek Lohia Journal of Clinical Medicine.2025; 14(13): 4801. CrossRef
The Gut Microbiome in Enteric Viral Infections: Underlying Mechanisms and Therapeutic Approaches Alejandro Borrego-Ruiz, Juan J. Borrego Microorganisms.2025; 13(10): 2247. CrossRef
Why patients’ knowledge alone isn’t enough: examining behavioral and attitudinal gaps in gestational diabetes management among Chinese women Yan Liang, Qingli Liu, Xiaoyun Sun, Yan Wang Frontiers in Public Health.2025;[Epub] CrossRef
Chimeric Antigen Receptor Immunotherapy for Infectious Diseases: Current Advances and Future Perspectives Maria Kourti, Paschalis Evangelidis, Emmanuel Roilides, Elias Iosifidis Pathogens.2025; 14(8): 774. CrossRef
Ascertaining the association between smoking behaviors and viral hepatitis risk: A Mendelian randomization approach Birong Lin, Huaxi Ma, Yan Lin, Ting Lin, Xiao Han, Minghua Lin, Haibing Gao Tobacco Induced Diseases.2025; 23(July): 1. CrossRef
Antimicrobial stewardship interventions involving community pharmacy teams: a scoping review Federico Zerbinato, Scott Cunningham, Antonella Pia Tonna JAC-Antimicrobial Resistance.2025;[Epub] CrossRef
Clinical and In vitro Data Shed New Light on the Therapeutic Advantages of Black Seeds (Nigella sativa) for the Treatment of Hepatitis C and Hepatitis B Viral Infections Naina Mohamed Pakkir Maideen, Rajkapoor balasubramanian, Kumar Balasubramanian, Mohamed Harsath Jahir Hussain, Mohamed Fahath Shahul Hameed, Rethesh Senthil Infectious Disorders - Drug Targets.2025;[Epub] CrossRef
Hepatitis C virus-associated cardiomyopathy: A review of pathogenesis Inderjeet Singh Bharaj, Gurkaranvir Singh, Ajit Singh Brar, Aayushi Kacheria, Jasraj Kahlon, Billal Mohmand, Aalam Sohal, Beeletsega T Yeneneh World Journal of Virology.2025;[Epub] CrossRef
Seroprevalence and Predictors of Hepatitis B and C Virus Infections Among Patients with Chronic Liver Diseases in Dodoma Region, Tanzania: A Cross-Sectional Study Daudi Gyunda, James Yahaya, Emmanuel Sindato, Alfred Meremo Hepatic Medicine: Evidence and Research.2025; Volume 17: 125. CrossRef
Opportunities and challenges for the application of artificial intelligence paradigms into the management of endemic viral infections: The example of Chronic Hepatitis C Virus Ahmed N. Farrag, Ahmed M. Kamel, Iman A. El‐Baraky Reviews in Medical Virology.2024;[Epub] CrossRef
Barriers and advocacy needs for hepatitis C services in prisons: Informing the prisons hepatitis C advocacy toolkit Shelley J Walker, Lok B Shrestha, Andrew R Lloyd, Olivia Dawson, Yumi Sheehan, Julia Sheehan, Nonso B C Maduka, Joaquin Cabezas, Matthew J Akiyama, Nadine Kronfli International Journal of Drug Policy.2024; 126: 104386. CrossRef
Contemporary Insights into Hepatitis C Virus: A Comprehensive Review Malik Sallam, Roaa Khalil Microorganisms.2024; 12(6): 1035. CrossRef
A Systematic Literature Review and Meta-Analysis of Primary Evidence Reporting Health-State Preference Values in Chronic Hepatitis B, C, and D Ankita Kaushik, Chong Hoon Kim, Sarah Hofmann, Maria João Janeiro, Andrew Lloyd, Filipa Aragão Value in Health.2024;[Epub] CrossRef
Reduced injection risk behavior with co-located hepatitis C treatment at a syringe service program: The accessible care model Claire So Jeong Lee, Pedro Mateu-Gelabert, Yesenia Aponte Melendez, Chunki Fong, Shashi N. Kapadia, Melinda Smith, Kristen M. Marks, Benjamin Eckhardt, Jason T. Blackard PLOS ONE.2024; 19(8): e0308102. CrossRef
A comparison of sofosbuvir/velpatasvir and glecaprevir/pibrentasvir for the treatment of hepatitis C infection among people who inject drugs Shana Yi, David Truong, Brian Conway Journal of Virus Eradication.2024; 10(3): 100388. CrossRef
Prospective approaches to target bovine viral diarrhea virus and hepatitis C virus using miRNA-based inhibitors Shazia Tabassum Hakim, Cayatineto HW Journal of Human Virology & Retrovirology.2024; 11(1): 36. CrossRef
Metagenomic Detection of Divergent Insect- and Bat-Associated Viruses in Plasma from Two African Individuals Enrolled in Blood-Borne Surveillance Gregory S. Orf, Ana Olivo, Barbara Harris, Sonja L. Weiss, Asmeeta Achari, Guixia Yu, Scot Federman, Dora Mbanya, Linda James, Samuel Mampunza, Charles Y. Chiu, Mary A. Rodgers, Gavin A. Cloherty, Michael G. Berg Viruses.2023; 15(4): 1022. CrossRef
Gastrointestinal tract and viral pathogens Gowthami Sai Kogilathota Jagirdhar, Yashwitha Sai Pulakurthi, Himaja Dutt Chigurupati, Salim Surani World Journal of Virology.2023; 12(3): 136. CrossRef
Hepatitis C virus seroprevalence, testing, and treatment capacity in public health facilities in Ghana, 2016–2021; A multi-centre cross-sectional study Yvonne Ayerki Nartey, Rafiq Okine, Atsu Seake-Kwawu, Georgia Ghartey, Yaw Karikari Asamoah, Ampem Darko Jnr Siaw, Kafui Senya, Amoako Duah, Alex Owusu-Ofori, Opei Adarkwa, Seth Agyeman, Sally Afua Bampoh, Lindsey Hiebert, Henry Njuguna, Neil Gupta, John W PLOS ONE.2023; 18(6): e0287580. CrossRef
Association of NK Cells with the Severity of Fibrosis in Patients with Chronic Hepatitis C Anna Kleczka, Bogdan Mazur, Krzysztof Tomaszek, Andrzej Gabriel, Radosław Dzik, Agata Kabała-Dzik Diagnostics.2023; 13(13): 2187. CrossRef
Rapid and sensitive LAMP/CRISPR-powered diagnostics to detect different hepatitis C virus genotypes using an ITO-based EG-FET biosensing platform Hsin-Ying Ho, Wei-Sin Kao, Piyush Deval, Chia-Yen Dai, Yen-Hsu Chen, Ming-Lung Yu, Che-Hsin Lin, Ling-Shan Yu Sensors and Actuators B: Chemical.2023; 394: 134278. CrossRef
Hepatitis C and hepatocellular carcinoma in Latin America: Elimination as a path to cancer prevention Spencer Goble, Angelo Z. Mattos, Manuel Mendizabal, Jose D. Debes Annals of Hepatology.2023; 28(6): 101149. CrossRef
Self-awareness of hepatitis C infection in the United States: A cross-sectional study based on the National Health Nutrition and Examination Survey Karthik Gnanapandithan, Maged P. Ghali, Yury E. Khudyakov PLOS ONE.2023; 18(10): e0293315. CrossRef
The Prevalence of Transfusion-Transmitted Diseases Among Blood Donors in the Central Blood Bank in Makkah, Saudi Arabia Mohammad Albshri, Palanisamy Manikandan, Mamdouh Allahyani, Abdulelah Aljuaid, Mazen M Almehmadi, Kamal Alzabeedi, Mohamed Babalgaith, Mosa Alghamdi, Faris Alharbi, Mohammed Alhazmi Cureus.2023;[Epub] CrossRef
Assessment of the influence of vitamin D level on the course of chronic hepatitis C in comorbidity with chronic pancreatitis M.A. Derbak, O.V. Buchok, T.M. Ganych, O.A. Rishko, V.V. Timashev INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(7): 478. CrossRef
Real-world treatment outcome of direct-acting antivirals and patient survival rates in chronic hepatitis C virus infection in Eritrea Ghirmay Ghebrekidan Ghebremeskel, Michael Berhe Solomon, Oliver Okoth Achila, Samuel Tekle Mengistu, Rahel Frezghi Asmelash, Araia Berhane Mesfin, Mohammed Elfatih Hamida Scientific Reports.2023;[Epub] CrossRef
DYNAMICS IN MAIN CLINICAL AND IMMUNOLOGICAL INDICATORS IN PATIENTS WITH COMORBIDITY OF CHRONIC HEPATITIS C AND CHRONIC PANCREATITIS FOLLOWING INTEGRATED THERAPY INCLUDING VITAMIN D M.A. Derbak, O.V. Buchok, O.O. Boldizhar, O.A. Rishko, M.M. Bletskan Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії.2023; 23(4): 84. CrossRef
PECULIARITIES OF THE FUNCTIONAL STATE OF THE LIVER IN PATIENTS WITH CHRONIC HEPATITIS C IN THE PRESENCE OF CHRONIC PANCREATITIS Mariya A. Derbak, Olha V. Buchok, Taras M. Ganich, Mariya V. Rivis, Yana V. Lazur, Viktoriya M. Polyak-Tovt, Volodymyr V. Timashev Wiadomości Lekarskie.2023; 76(11): 2359. CrossRef
Impact of the direct acting antivirals on chronic hepatitis C prevalence on the Swiss organ transplantation list: a retrospective analysis Luis Falcato, Simone Temperli, Philip Bruggmann, Franz Immer Exploration of Digestive Diseases.2023; 2(6): 297. CrossRef
ВИВЧЕННЯ ЕФЕКТИВНОСТІ ВІТАМІНУ D В СКЛАДІ КОМПЛЕКСНОЇ ТЕРАПІЇ ХРОНІЧНОГО ГЕПАТИТУ С ПОЄДНАНОГО З ХРОНІЧНИМ ПАНКРЕАТИТОМ Ольга Бучок , М. Дербак Grail of Science.2023; (34): 360. CrossRef
Impact of the direct acting antivirals on chronic hepatitis C prevalence on the Swiss organ transplantation list: a retrospective analysis Luis Falcato, Simone Temperli, Philip Bruggmann, Franz Immer Exploration of Digestive Diseases.2023;[Epub] CrossRef
THE EFFECT OF COMPLEX THERAPY INCLUDING VITAMIN D ON THE QUALITY OF LIFE OF PATIENTS WITH CHRONIC HEPATITIS C COMBINED WITH CHRONIC PANCREATITIS M. A. Derbak, O. V. Buchok, O. O. Boldizhar, M. M. Bletskan, V. V. Svistak Bulletin of Problems Biology and Medicine.2023; 1(2): 166. CrossRef
Intrafamilial transmission risk factors and preventive measures followed by household contacts of hepatitis C patients Amala Abdulla Saad Ahmed, Saneya Mohamed Rizk, Nabila Abdel-Kader Abdeldaiem Egyptian Nursing Journal.2023; 20(2): 159. CrossRef
Another Step Toward Hepatitis C Elimination: An Economic Evaluation of an Irish National Birth Cohort Testing Program Paul G. Carty, Conor Teljeur, Cillian F. De Gascun, Paddy Gillespie, Patricia Harrington, Aiden McCormick, Michelle O’Neill, Susan M. Smith, Mairin Ryan Value in Health.2022; 25(12): 1947. CrossRef
Oncogenic viruses, cancer biology, and innate immunity Maria C White, Xinjun Wu, Blossom Damania Current Opinion in Immunology.2022; 78: 102253. CrossRef