Journal of Preventive Medicine and Public Health

English Abstract

Association of Blood Pressure Levels with Carotid Intima-Media Thickness and Plaques.: Young Hoon Lee, Sun Seog Kweon, Jin Su Choi, Jung Ae Rhee, Sung Woo Choi, So Yeon Ryu, Min Ho Shin; J Prev Med Public Health. 2009;42(5):298-304.; DOI: https://doi.org/10.3961/jpmph.2009.42.5.298

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OBJECTIVES
The aim of this study was to investigate the association of blood pressure levels with the common carotid artery intima-media thickness (CCA-IMT) and carotid plaques. METHODS: Data were obtained from 2,635 subjects, aged 50 years and over, who participated in the Community Health Survey (a population-based, cross-sectional study) in Dong-gu, Gwangju city between 2007 and 2008. Participants were categorized into three groups according to blood pressure levels; normotensives (<120/80 mmHg), prehypertensives (120-139/80-89 mmHg), and hypertensives (> or =140/90 mmHg). Prehypertensives were further categorized as low prehypertensives (120-129/80-84 mmHg) and high prehypertensives (130-139/85-89 mmHg). Carotid intima-media thickness and plaques were evaluated with a high-resolution B-mode ultrasound. Statistical analyses were performed using chi-square test, ANOVA, and multiple logistic regression. RESULTS: Prehypertensives had significantly greater maximal CCA-IMT values than normotensives, with a multivariate adjusted odds ratio of 1.78 (95% CI=1.36-2.32) for abnormal CCA-IMT (maximal CCA-IMT > or =1.0 mm), and 1.45 (95% CI=1.19-1.77) for carotid plaques. The multivariate adjusted odds ratio of low prehypertensives was 1.64 (95% CI=1.21-2.21) for abnormal CCA-IMT, and 1.30 (95% CI=1.04-1.63) for carotid plaques compared with normotensives. Subject with hypertension had higher frequency of abnormal CCA-IMT (odds ratio, 2.18; 95% CI=1.49-3.18), and carotid plaques (odds ratio, 1.98; 95% CI=1.46-2.67) compared with normotensives after adjustment for other cardiovascular risk factors. CONCLUSIONS: Our results indicate that there is a significant increase in the prevalence of carotid atherosclerosis in subjects with prehypertension (even in low prehypertensives) compared with normotensive subjects. Further studies are required to confirm the benefits and role of carotid ultrasonography in persons with prehypertension.

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Citations

Citations to this article as recorded by

Association Between Serum Uric Acid and Carotid Intima-Media Thickness in Different Fasting Blood Glucose Patterns: A Case-Control Study
Yuanyuan Gao, Baofeng Xu, Yanyan Yang, Mei Zhang, Tian Yu, Qiujuan Zhang, Jianwei Sun, Rui Liu
Frontiers in Endocrinology.2022;[Epub] CrossRef
School children systolic and diastolic blood pressure values: YUSAD study
Zeljka Milincic, Dejan Nikolic, Slavko Simeunovic, Ivana Novakovic, Ivana Petronic, Dijana Risimic, Dejan Simeunovic
Open Medicine.2011; 6(5): 634. CrossRef

Research Support, Non-U.S. Gov't

Impact of Multiple Cardiovascular Risk Factors on the Carotid Intima-media Thickness in Young Adults: The Kangwha Study.: Hoo Sun Chang, Hyeon Chang Kim, Song Vogue Ahn, Nam Wook Hur, Il Suh; J Prev Med Public Health. 2007;40(5):411-417.; DOI: https://doi.org/10.3961/jpmph.2007.40.5.411

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Abstract PDF

OBJECTIVES
Although risk factors for coronary artery disease are also associated with increased carotid intima-media thickness (IMT), there is little information available on the asymptomatic, young adult population. We examined the association between multiple cardiovascular risk factors and the common carotid IMT in 280 young Korean adults. METHODS: The data used for this study was obtained from 280 subjects (130 men and 150 women) aged 25 years who participated in the Kangwha Study follow-up examination in 2005. We measured cardiovascular risk factors, including anthropometrics, blood pressure, blood chemistry, carotid ultrasonography, and reviewed questionnaires on health behaviors. Risk factors were defined as values above the sex-specific 75th percentile of systolic blood pressure, body mass index, total cholesterol/high-density lipoprotein cholesterol ratio, fasting blood glucose and smoking status. RESULTS: The mean carotid IMT+/-standard deviation observed was 0.683+/-0.079 mm in men and 0.678+/-0.067 mm in women (p=0.567) and the evidence of plaque was not observed in any individuals. Mean carotid IMT increased with an increasing number of risk factors(p for trend <0.001) and carotid IMT values were 0.665 mm, 0.674 mm, 0.686 mm, 0.702 mm, and 0.748 mm for 0, 1, 2, 3, and 4 to 5 risk factors, respectively. The odds ratio for having the top quartile carotid IMT in men with 3 or more risk factors versus 0-2 risk factors was 5.09 (95% CI, 2.05-12.64). CONCLUSIONS: Current findings indicate the need for prevention and control of cardiovascular risk factors in young adults and more focus on those with multiple cardiovascular risk factors.

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Citations

Citations to this article as recorded by

Association Between Risk Factors in Childhood and Sex Differences in Prevalence of Carotid Artery Plaques and Intima‐Media Thickness in Mid‐Adulthood in the Childhood Determinants of Adult Health Study
Mohammad Shah, Marie‐Jeanne Buscot, Jing Tian, Hoang T. Phan, Brooklyn J. Fraser, Thomas H. Marwick, Terence Dwyer, Alison Venn, Seana Gall
Journal of the American Heart Association.2023;[Epub] CrossRef
Association between Fibrinogen and Carotid Atherosclerosis According to Smoking Status in a Korean Male Population
Hye Min Cho, Dae Ryong Kang, Hyeon Chang Kim, Sun Min Oh, Byeong-Keuk Kim, Il Suh
Yonsei Medical Journal.2015; 56(4): 921. CrossRef
Myocardial perfusion and intima-media thickness in patients with subclinical hypothyroidism
M Knapp, A Lisowska, B Sobkowicz, A Tycińska, R Sawicki, WJ Musiał
Advances in Medical Sciences.2013; 58(1): 44. CrossRef
Association between Depressive Symptoms and Bone Stiffness Index in Young Adults: The Kangwha Study
Sun Min Oh, Hyeon Chang Kim, Kyoung Min Kim, Song Vogue Ahn, Dong Phil Choi, Il Suh, Chih-Hsin Tang
PLoS ONE.2013; 8(7): e69929. CrossRef
The importance of intima-media thickness (IMT) measurements in monitoring of atherosclerosis progress after myocardial infarction
A Lisowska, M Knapp, S Bolińska, P Lisowski, A Krajewska, B Sobkowicz, WJ Musiał
Advances in Medical Sciences.2012; 57(1): 112. CrossRef
Association between Blood Pressure and Carotid Intima-Media Thickness
Sun Min Lim, Hyeon Chang Kim, Hoon Sang Lee, Joo Young Lee, Mina Suh, Song Vogue Ahn
The Journal of Pediatrics.2009; 154(5): 667. CrossRef

Original Article

A Cross-sectional Study on the Risk Factors Related to Fatty Liver.: S H Ohm, B C Yoo, S J Kim, C U Lee, K T Pai, S C Kim, H R Shin; Korean J Prev Med. 1993;26(2):179-191.

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Abstract PDF: Generally fatty liver is attributed either to chronic alcoholism, diabetes mellitus, or obesity. Based upon this commonly held clinical brief, this study was conducted to investigate the contributing factors of fatty liver and odds ratio (OR) of known contributing factors. A sample of 310 male participants, who visited at Seoul Paik Automated Multiphasic Health Testing System from November 1991 to December 1991, was separated into 112 cases and 198 controls by ultrasonographic finding. There were statistically significant difference between fatty liver and normal in triglyceride(TG), body mass index(BMI), alanine aminotransferase(ALT), high density lipoprotein cholesterol (HDL-C), fasting blood sugar (FBS), alcohol consumption, low density lipoprotein cholesterol (LDL-C), total cholesterol, gamma-glutamyl transferase (gamma-GT), duration of alcohol intake and alkaline phospahtase (Alk.P)(P<0.01, P<0.05). The statistically significant elevated odds ratio were noted for TG (4.48, confidence interval (CI) 2.66-7.55, P=0.000), alcohol consumption(3.24, CI 1.56-6.23, P=0.002), BMI(3.05, CI 1.87-4.97, P=0.000), and FBS(2.59, CI 1.53-4.40, P=0.000). In summary, it is suggested that the fatty liver could be preventive by avoiding such deleterious factors as high fat diet, alcohol and obesity.; Summary

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