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J Prev Med Public Health > Volume 41(2); 2008 > Article
Journal of Preventive Medicine and Public Health 2008;41(2): 107-114. doi: https://doi.org/10.3961/jpmph.2008.41.2.107
The Association between Obesity Indices in Adolescence and Carotid Intima-media Thickness in Young Adults: Kangwha Study.
Yoo Jung Lee, Chung Mo Nam, Hyeon Chang Kim, Nam Wook Hur, Il Suh
1Graduate School of Public Health, Yonsei University, Seoul, Korea.
2Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
3Biomedical Research Group, Hanyang Brain Korea 21, Hanyang University, Seoul, Korea. nwhur@hanyang.ac.kr
ABSTRACT
OBJECTIVES: The aim of this study is to investigate the association between obesity indices (body mass index, weight, waist-hip ratio and waist circumference) in adolescents and the carotid intima-media thickness (C-IMT) in early adulthood. We also wanted to identify the best predictor for C-IMT among these obesity indices. METHODS: This study used community-based prospective cohort study, known as the Kangwha Study, and the data we used were from subjects who were 16-years old in 1996 (defined as "adolescencec") and 25 years-old in 2005 (defined as "early adulthoodc"). The 256 subjects (113 men and 143 women) who were used for analysis participated in both follow-ups, and they underwent B-mode ultrasonography of the carotid arteries at the early adulthood follow-up. Obesity indices were defined as the body mass index, weight, waist-hip ratio and waist circumference. The C-IMT was defined as the mean of the maximal IMT of each common carotid artery. The C-IMT and obesity indices associations were evaluated via multivariable regression, logistic regression and the receiver-operator characteristic curve analyses. RESULTS: In men, all the obesity indices in adolescence were showed to have statistically significant positive association with C-IMT in early adulthood. However, no such relationship was showed in women. On multiple regression and logistic regression analysis, the waist-hip ratio showed the biggest relationship with the C-IMT among the 4 obesity indices. However, there were no statistical significant differences and no best predictor was found. For the women, the obesity incidences and C-IMT showed no relationships. CONCLUSIONS: This study suggested that obesity in adolescence was related to an increase C-IMT in healthy young Korean men.
Key words: Obesity; Carotid artery thrombosis; Adult; Adolescence
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