Cigarette Smoking and Gastric Cancer Risk in a Community-based Cohort Study in Korea.

Yeonju Kim; Aesun Shin; Jin Gwack; Jae Kwan Jun; Sue Kyung Park; Daehee Kang; Hai Rim Shin; Soung Hoon Chang; Keun Young Yoo

doi:10.3961/jpmph.2007.40.6.467

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Multicenter Study Cigarette Smoking and Gastric Cancer Risk in a Community-based Cohort Study in Korea.: Yeonju Kim, Aesun Shin, Jin Gwack, Jae Kwan Jun, Sue Kyung Park, Daehee Kang, Hai Rim Shin, Soung Hoon Chang, Keun Young Yoo; Journal of Preventive Medicine and Public Health 2007;40(6):467-474
DOI: https://doi.org/10.3961/jpmph.2007.40.6.467

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¹Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. kyyoo@ncc.re.kr
²Division of Cancer Prevention, National Cancer Control Research Institute, National Cancer Center, Goyang, Korea.
³Department of Preventive Medicine, Konkuk University College of Medicine, Chungju, Korea.
⁴National Cancer Center, Goyang, Korea

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Abstract

OBJECTIVES
Gastric cancer is the most common incident cancer in Korea. Although Helicobacter pylori infection is the most important risk factor for the development of gastric cancer, cigarette smoking has also been suggested to play an important role in the development of gastric cancer. The objective of this study is to evaluate the relationship between cigarette smoking and gastric cancer risk in a Korean population. METHODS: The study population consisted of 13,785 subjects who had been enrolled in the Korean Multi-Center Cancer Cohort between 1993 and 2002. As of December 2002, 139 incident gastric cancer cases were ascertained through the Korea Central Cancer Registry and the National Death Certificate Database. Relative risks (RR) and 95% confidence intervals (CI) for gastric cancer were estimated using CoxZs proportional hazard model adjusted for age, education, alcohol drinking status and history of gastritis or ulcer. RESULTS: Significant dose-response relationships were observed between the duration of smoking and the risk of gastric cancer among the male subjects in comparison to non-smokers: men who smoked for 20-39 years had a 2.09- fold (95% CI 1.00-4.38) increase, and those who smoked for more than 40 years had a 3.13-fold (95% CI 1.59-6.17) increase in the risk of gastric cancer (Ptrend<0.01). CONCLUSIONS: This study suggests that a longer duration of cigarette smoking may increase the risk of gastric cancer development in a dose-response manner in Korean men. The association between smoking and gastric cancer risk in women should be verified in future studies with a larger number of cases.

Keywords: Stomach neoplasms;Smoking;Cohort studies;Korea

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