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Korean Journal of Preventive Medicine 2003;36(3): 209-212.
Specimen Storage and Analysis for Genomic Epidemiology.
Yun Chul Hong, Kwan Hee Lee
Department of Social and Preventive Medicine, Inha University College of Medicine, Korea.
ABSTRACT
Because of advances of technologies in the field of genomic epidemiology in the recent years, specimen collection, storage and analysis became an essential part of research methodologies. DNA is now being used in epidemiologic studies to evaluate genetic risk factors and specimens other than the fresh whole blood can be used for PCR. Therefore, All nucleated cells, such as buccal swabs and urine specimens, are suitable for DNA analysis. For an unlimited source of genomic DNA, EBV transformation of lymphocytes can be used for immortalization. However, the type of specimen collected in genomic epidemiologic studies will depend on the study where the epidemiologist play a leading role for the design. We also briefly described various kinds of analysis for SNP that is an essential part of the genomic epidemiology.
Key words: Genome; Molecular epidemiology; Biological specimen bank; Single nucleotide polymorphism
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