A cross-sectional study was conducted to investigate the prevalence and risk factors for symptoms associated with sick building syndrome in four office buildings located in Seoul. Information on personal factors, job-related factors, and medical history were collected using self-administered questionnaires modified from the National Institute for Occupational Safety and Health Indoor Air Quality questionnaire in 321 office workers in these buildings. The prevalence of general and irritant symptom groups was higher than the prevalence of dermatologic and respiratory symptom groups. Daily total work time, work time in the office, and work time with video display terminals(VDT) were identified as the risk factors for symptom groups associated with sick building syndrome by multiple linear logistic regression analysis. In conclusion, these results indicated that the symptom prevalence in this study is similar with the results reported from previous studies conducted in other countries and work time and work with VDT are related to sick building syndrome in Korea.