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Korean Journal of Preventive Medicine 1995;28(1): 141-152.
Effects of Ethanol on the Activities and Inducibility of Trichloroethylene Metabolic Enzyme System in Rat Liver.
Ki Woong Kim, Seung Kyu Kang, Young Sook Cho, Sei Hui Lee, Young Hahn Moon, Byung Soon Choi, Sang Shin Park
1Industrial Health Research Institute, KISCO, Korea.
2College of Medicine, Dongguk University, Korea.
3National Cancer Institute, Laboratory of Comparative Carcinogenesis, Korea.
ABSTRACT
This study was performed to find out the influences of ethanol on the metabolism of trichloroethylene(TRI) in rats. TRI in corn oil at the dosage of 150, 300, 600 mg/kg was injected peritoneally once a day for two days to two groups. In one group ethanol(4 g/kg) was taken orally 30 minutes before TRI injection, and the other group ethanol was not. The results of experiments are as follows: 1. The contents of cytochrome P-450 and b5 had inverse relationship with in-jected TRI amounts in both groups. 2. The activity of NADPH P-450 reductase was decreased slowly in TRI injected group related with TRI amount, but decreased drastically in the group pretreated with ethanol. 3. The activity of NADH b5 reductase had relationship with injected TRI amount, but the statistical significance was found only in the groups of 300 and 600 mg/kg of TRI injected without relevance to ethanol when compared with the group that was not injected. 4. The activity of ADH was more decreased and ALDH activity was more increased in groups that TRI injected and ethanol was pretreated with ethanol groups than in group without any treatment. These results suggest that ethanol may inhibit epoxide formulation, the first step or TRI metabolism, and change from TCE-OH to TCA also.
Key words: Trichloroethylene; Ethanol; Cytocchrome P-450 Monooxygenase
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