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Korean Journal of Preventive Medicine 1992;25(2): 180-188.
Effects of Multiple Exposures to Pesticides on Plasma Cholinesterase Activity and p-nitrophenol Excretion in Rats.
Bong Suk Cha, Jung Gyun Park, Jong Ku Park, Sei Jin Chang
1Department of Preventive Medicine, Yonsei Iniversity Wonju College of Medicine, Korea.
2Institute of Occupational Medicine, Yonsei Iniversity Wonju College of Medicine, Korea.
ABSTRACT
The effects of multiple exposures to pesticides on plasma cholinesterase(ChE) activities and urinary p-nitrophenol excretion were evaluated in rats. Rats were received single dose i.p. with LD50/100(mg/kg) of organophosphorous(OP), organophosphorous-organochroline(OP-OC), organophosphorous-carbamate(OP-CAB), organophosphorous-organoarsenate(OP-OA) pesticides for 4 consecutive days. In repeated administration of pesticides, plasma ChE activities were decreased, but urinary p-nitrophenol were increased after the first injection and then decreased gradually. The recovery rates of ChE activities and p-nitrophenol excretion at 48 hours after the fourth infection were delayed in comparison with the baseline value of 24 hours before the first injection. Statistical significances were found between OP and other groups except OP-OA group after the second injection in plasma ChE activities, but in urinary p-nitrophenol excretion there was statistical significance only between OP and OP-CAB.
Key words: pesticide; plasma cholinesterase; urinary p-nitrophenol
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