Korean J Prev Med. 1997; 30(1): 69-76.
Histopatholigical Changes of Subcutaneous Exposure to Glass Fibers in Rats.
1Department of Pathology, Seoul National University College of Medicine, Korea.
2Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
To exanime in vivo tissue reactions of glass fibers, we injected glass fibers to rats subcutaneously. We made fibers of average dimensions of approximately 2 nm in diameter and 60 nm in length. After instilation of glass fiber we sacrificed rats sequentially at 1, 3 and 6 months. At 1 month after injection of glass fibers, the exposure area turned to yellow color and formed well-demarcated round mass. The average size of the mass was 1X0.3 cm. Grossly detectable mass was decreased in size at 6 months compared to 1 or 3 months. Microscopically, strong foreign body reaction to glass fibers, inflammation and fibrosis were observed until 6 months. Foreign body reaction was increased up to 3 months, but it was decreased after 6 months. In scanning electron microscope, there was many bundles of glass fibers around the inflammation area, but the size of glass fibers were gradually reduced from 1 month to months. These results suggest that subcutaneous exposure of glass fiber can provoke strong tissue reaction including foreign body granulomas, inflammation and fibrosis. But glass fiber itself did not produce any neoplastic changes.
Glass fiver;Subcutaneous exposure;Foreign body reaction, Rat