Korean J Prev Med. 1997; 30(1): 17-30.
Seroepidemiologic Study of Hepatitis B Virus(HBV) and Hepatitis C Virus(HCV) Infection among Koreans in Rural Area, Korea.
Hai Rim Shin
, Joon Youn Kim
, Jue Bok Song
, Byung Seong Suh
, Jung Man Kim
, Bu Ok Lee
, Su Ryang Kim
, Mu Guan Yang
, Chae Un Lee
, Jin Ho Chun
, Keun Young Yoo
, and Yoon Ok Ahn
1Department of Preventive Medicine, College of Medicine, Dong-A University, Pusan, Korea.
2Department of Clinical Pathology, College of Medicine, Dong-A University, Pusan, Korea.
3Haman Medical Health Center, Kyung-nam Province, Korea.
4kobe Asahi Hospital Kobe, Japan.
5Department of Preventive Medicine, College of Medicine, Inje University, Pusan, Korea.
6Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Korea.
To estimate the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and to determine associated risk factors, a population-based seroepidemiologic study was carried out. In 1993, a health examination survey of the population was carried out in rural area known to have a high incidence of liver cancer. The study population were those who volunteered to participate in a health survey over 10 years of age. Examinees were interviewed by specially trained staffs. Sera from 1,033 study subjects were tested for hepatitis B surface antigen (HBsAg) by reverse passive hemagglutinin (RPHA) estimation and for hepatitis C virus antibody (anti-HCV) by 2nd generation passive hemagglutinin (PHA) estimation, The age and sex standardized prevalence of HBsAg was 6.3% which was similar to national average, but that of anti-HCV was 5.1% which was 4 to 5 times higher than that of blood or other health examinees in Korea. In a multivariate analysis, transfusion history, surgical operative history, and acupuncture history were not associated with HBsAg positivity. In contrast, acupuncture history (adjusted odds ratio[OR]=2.2 : 95% Confidence interval[CI] 1.0-4.7) and surgical operative history(adjusted OR=2.0 : 95% CI 1.0-4.1) were associated with anti-HCV positivity. The present study suggest that there is an highly endemic area of HCV infection in Korea and probably this endemicity is associated with a parenteral source of HCV infection other than blood transfusion.
Hepatitis B virus infection;Hepatitis C virus infection;Prevalence;Risk factors