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Dong Young Noh 2 Articles
Risk Reduction of Breast Cancer by Childbirth, Breastfeeding, and Their Interaction in Korean Women: Heterogeneous Effects Across Menopausal Status, Hormone Receptor Status, and Pathological Subtypes
Seok Hun Jeong, Yoon Suk An, Ji-Yeob Choi, Boyoung Park, Daehee Kang, Min Hyuk Lee, Wonshik Han, Dong Young Noh, Keun-Young Yoo, Sue K. Park
J Prev Med Public Health. 2017;50(6):401-410.   Published online November 10, 2017
DOI: https://doi.org/10.3961/jpmph.17.152
  • 8,509 View
  • 263 Download
  • 9 Crossref
AbstractAbstract PDFSupplementary Material
Objectives
The purpose of this study was to examine the associations of childbirth, breastfeeding, and their interaction with breast cancer (BC) risk reduction, and to evaluate the heterogeneity in the BC risk reduction effects of these factors by menopause, hormone receptor (HR) status, and pathological subtype.
Methods
BC patients aged 40+ from the Korean Breast Cancer Registry in 2004-2012 and controls from the Health Examinee cohort participants were included in this study after 1:1 matching (12 889 pairs) by age and enrollment year. BC risk according to childbirth, breast-feeding, and their interaction was calculated in logistic regression models using odds ratios (ORs) and 95% confidence intervals (CIs).
Results
BC risk decreased with childbirth (3+ childbirths relative to 1 childbirth: OR, 0.66; 95% CI, 0.56 to 0.78 and OR, 0.80; 95% CI, 0.68 to 0.95 in postmenopausal and premenopausal women, respectively); and the degree of risk reduction by the number of children was heterogeneous according to menopausal status (p-heterogeneity=0.04), HR status (p-heterogeneity<0.001), and pathological subtype (p-heterogeneity<0.001); whereas breastfeeding for 1-12 months showed a heterogeneous association with BC risk according to menopausal status, with risk reduction only in premenopausal women (p-heterogeneity<0.05). The combination of 2 more childbirths and breastfeeding for ≥13 months had a much stronger BC risk reduction of 49% (OR, 0.51; 95% CI, 0.45 to 0.58).
Conclusions
This study suggests that the combination of longer breastfeeding and more childbirths reduces BC risk more strongly, and that women who experience both 2 or more childbirths and breastfeed for ≥13 months can reduce their BC risk by about 50%.
Summary

Citations

Citations to this article as recorded by  
  • Association of reproductive risk factors and breast cancer molecular subtypes: a systematic review and meta-analysis
    Xihua Mao, Chioma Omeogu, Shama Karanth, Ashwini Joshi, Clare Meernik, Lauren Wilson, Amy Clark, April Deveaux, Chunyan He, Tisha Johnson, Karen Barton, Samantha Kaplan, Tomi Akinyemiju
    BMC Cancer.2023;[Epub]     CrossRef
  • Perikonzeptionelle Beratung bei Risikokonstellationen
    Christian Gnoth, Mareen ten Busch, Nadine Sutter, Peter Mallmann
    Journal für Gynäkologische Endokrinologie/Schweiz.2022; 25(4): 176.     CrossRef
  • Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer
    Eun Ji Sim, Kwang-Pil Ko, Choonghyun Ahn, Sang Min Park, Young-Joon Surh, Seokyung An, Sung-Won Kim, Min-Hyuk Lee, Jong Won Lee, Jeong Eon Lee, Ku Sang Kim, Cha Kyong Yom, Hyun-Ah Kim, Sue K. Park
    Breast Cancer Research and Treatment.2020; 184(2): 615.     CrossRef
  • Combination of circulating miR-145-5p/miR-191-5p as biomarker for breast cancer detection
    Yeldar Ashirbekov, Arman Abaildayev, Nazgul Omarbayeva, Dauren Botbayev, Ayaz Belkozhayev, Anel Askandirova, Alena Neupokoyeva, Gulzhakhan Utegenova, Kamalidin Sharipov, Nagima Aitkhozhina
    PeerJ.2020; 8: e10494.     CrossRef
  • PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects
    Daniela Miricescu, Alexandra Totan, Iulia-Ioana Stanescu-Spinu, Silviu Constantin Badoiu, Constantin Stefani, Maria Greabu
    International Journal of Molecular Sciences.2020; 22(1): 173.     CrossRef
  • Perikonzeptionelle Beratung bei Risikokonstellationen
    Christian Gnoth, Mareen ten Busch, Nadine Sutter, Peter Mallmann
    Der Gynäkologe.2019; 52(10): 779.     CrossRef
  • Epidemiological characteristics of breast cancer in Koreans
    Sue K. Park
    Journal of the Korean Medical Association.2019; 62(8): 424.     CrossRef
  • The contribution of breastfeeding to the prevention of breast cancer
    ASIMENIA MAMAKOU
    European Journal of Midwifery.2019;[Epub]     CrossRef
  • Maternal Personality and Psychosocial Variables Associated with Initiation Compared to Maintenance of Breastfeeding: A Study in Low Obstetric Risk Women
    Patricia Catala, Cecilia Peñacoba, Javier Carmona, Dolores Marin
    Breastfeeding Medicine.2018; 13(10): 680.     CrossRef
Incidence of Female Breast Cancer in a Defined Area in Korea.
Keun Young Yoo, Sue Kyung Park, Joo Hon Sung, Dong Young Noh, Kuk Jin Choe
Korean J Prev Med. 1998;31(4):592-603.
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AbstractAbstract PDF
This study was conducted to estimate incidence rate of female breast cancer in a defined area of Chungchongbuk-do in Korea. The presumptive breast cancer cases were selected from two different sources, i.e., medical utilization database of the National Health Insurance Corporation and the database from the National Cancer Registry. Medical students visited each hospital where the presumptive cases had been treated as a breast cancer patient, and made a dictation of medical record of each patient based on the claims stored in the Insurance Corporation from January to December 1995. The diagnoses in the claims included one of the following diagnostic codes; ICD-9 174-175(malignant neoplasms of the breast), 233(carcinoma in situ of the breast and genito-urinary system)or ICD-10 C50(malignant neoplasms of the breast), D05(carcinoma in situ of the breast and genito-urinary system). Each case has been confirmed as having a breast cancer by a breast surgeon through a medical record review. Age-standardized incidence rate of female breast cancer to the Korean population was estimated to be 10.5(95%confidence interval : 8.1-12.9)per 100,000 persons in 1995. Age-standardized rate to the world population was 9.8 per 100,000 persons, and the truncated rate for ages 35-64 was 27.2 per 100,000 persons. Validity of these estimates is discussing in comparison with previous methods of incidence estimation in Korea.
Summary

JPMPH : Journal of Preventive Medicine and Public Health