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En-Joo Jung 2 Articles
Interaction of Body Mass Index and Diabetes as Modifiers of Cardiovascular Mortality in a Cohort Study
Seung Hyun Ma, Bo-Young Park, Jae Jeong Yang, En-Joo Jung, Yohwan Yeo, Yungi Whang, Soung-Hoon Chang, Hai-Rim Shin, Daehee Kang, Keun-Young Yoo, Sue Kyung Park
J Prev Med Public Health. 2012;45(6):394-401.   Published online November 29, 2012
DOI: https://doi.org/10.3961/jpmph.2012.45.6.394
  • 9,968 View
  • 93 Download
  • 13 Crossref
AbstractAbstract PDF
Objectives

Diabetes and obesity each increases mortality, but recent papers have shown that lean Asian persons were at greater risk for mortality than were obese persons. The objective of this study is to determine whether an interaction exists between body mass index (BMI) and diabetes, which can modify the risk of death by cardiovascular disease (CVD).

Methods

Subjects who were over 20 years of age, and who had information regarding BMI, past history of diabetes, and fasting blood glucose levels (n=16 048), were selected from the Korea Multi-center Cancer Cohort study participants. By 2008, a total of 1290 participants had died; 251 and 155 had died of CVD and stroke, respectively. The hazard for deaths was calculated with hazard ratio (HR) and 95% confidence interval (95% CI) by Cox proportional hazard model.

Results

Compared with the normal population, patients with diabetes were at higher risk for CVD and stroke deaths (HR, 1.84; 95% CI, 1.33 to 2.56; HR, 1.82; 95% CI, 1.20 to 2.76; respectively). Relative to subjects with no diabetes and normal BMI (21 to 22.9 kg/m2), lean subjects with diabetes (BMI <21 kg/m2) had a greater risk for CVD and stroke deaths (HR, 2.83; 95% CI, 1.57 to 5.09; HR, 3.27; 95% CI, 1.58 to 6.76; respectively), while obese subjects with diabetes (BMI ≥25 kg/m2) had no increased death risk (p-interaction <0.05). This pattern was consistent in sub-populations with no incidence of hypertension.

Conclusions

This study suggests that diabetes in lean people is more critical to CVD deaths than it is in obese people.

Summary

Citations

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  • Development and validation of multicentre study on novel Artificial Intelligence-based Cardiovascular Risk Score (AICVD)
    Shiv Kumar Jalepalli, Prashant Gupta, Andre L A J Dekker, Inigo Bermejo, Sujoy Kar
    Family Medicine and Community Health.2024; 12(Suppl 1): e002340.     CrossRef
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    Kundan Solanki, Sajjan Rajpoot, Evgeny E. Bezsonov, Alexander N. Orekhov, Rohit Saluja, Anita Wary, Cassondra Axen, Kishore Wary, Mirza S. Baig
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  • Obesity and metabolic outcomes in a safety-net health system
    Michael P. Huynh, Patrick T. Bradshaw, Michele M. Tana, Carly Rachocki, Ma Somsouk
    Biodemography and Social Biology.2020; 65(3): 257.     CrossRef
  • Lifestyle Factors and Gender-Specific Risk of Stroke in Adults with Diabetes Mellitus: A Case-Control Study
    Jian Guo, Tianjia Guan, Ying Shen, Baohua Chao, Mei Li, Longde Wang, Yuanli Liu
    Journal of Stroke and Cerebrovascular Diseases.2018; 27(7): 1852.     CrossRef
  • Nonlinear association of BMI with all-cause and cardiovascular mortality in type 2 diabetes mellitus: a systematic review and meta-analysis of 414,587 participants in prospective studies
    Francesco Zaccardi, Nafeesa N. Dhalwani, Dimitris Papamargaritis, David R. Webb, Gavin J. Murphy, Melanie J. Davies, Kamlesh Khunti
    Diabetologia.2017; 60(2): 240.     CrossRef
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    Jana Engelmann, Ulf Manuwald, Constanze Rubach, Joachim Kugler, Andreas L. Birkenfeld, Markolf Hanefeld, Ulrike Rothe
    Reviews in Endocrine and Metabolic Disorders.2016; 17(1): 129.     CrossRef
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    Hyun Kyung Park, Su Kang Kim, Oh Young Kwon, Joo-Ho Chung, Seong-Kyu Lee
    Molecular & Cellular Toxicology.2016; 12(2): 217.     CrossRef
  • Association between different obesity measures and the risk of stroke in the EPIC Spanish cohort
    Itziar Abete, Larraitz Arriola, Nerea Etxezarreta, Imanol Mozo, Conchi Moreno-Iribas, Pilar Amiano, Nerea Egüés, Estibaliz Goyenechea, Adolfo Lopez de Munain, Maite Martinez, Noemi Travier, Carmen Navarro, Maria-Dolores Chirlaque, Maria-Jose Tormo, Diana
    European Journal of Nutrition.2015; 54(3): 365.     CrossRef
  • Relationship of body mass index and abdominal obesity in rural population of Krasnodarsky kray taken
    Elena V. Bolotova, Irina V. Samorodskaya, Irina M. Komissarova
    Obesity and metabolism.2015; 13(1): 25.     CrossRef
  • Associations of prediabetes with all-cause and cardiovascular mortality: A meta-analysis
    Yi Huang, Xiaoyan Cai, Peisong Chen, Weiyi Mai, Hongfeng Tang, Yuli Huang, Yunzhao Hu
    Annals of Medicine.2014; 46(8): 684.     CrossRef
  • High Peritoneal Transport Status Was Not Associated with Mortality in Peritoneal Dialysis Patients with Diabetes
    Naya Huang, Jiehui Chen, Li Fan, Qian Zhou, Qingdong Xu, Ricong Xu, Liping Xiong, Xueqing Yu, Haiping Mao, Zhanjun Jia
    PLoS ONE.2014; 9(10): e110445.     CrossRef
  • Body Mass Index and Mortality Among Japanese Patients With Type 2 Diabetes: Pooled Analysis of the Japan Diabetes Complications Study and the Japanese Elderly Diabetes Intervention Trial
    Shiro Tanaka, Sachiko Tanaka, Satoshi Iimuro, Yasuo Akanuma, Yasuo Ohashi, Nobuhiro Yamada, Atsushi Araki, Hideki Ito, Hirohito Sone
    The Journal of Clinical Endocrinology & Metabolism.2014; 99(12): E2692.     CrossRef
  • Validação cruzada entre o percentual de gordura mensurado pela absortometria radiológica de dupla energia e a equação de Deurenberg em idosas
    Piettra Moura Galvão-Pereira, Giselma Alcantara-Silva, Adriano Eduardo Lima-Silva, Dante Wanderley Lima, Amandio Aristides Rihan Geraldes
    Revista Brasileira de Geriatria e Gerontologia.2013; 16(4): 681.     CrossRef
Alcohol Consumption and Mortality in the Korean Multi-center Cancer Cohort Study
En-Joo Jung, Aesun Shin, Sue K. Park, Seung-Hyun Ma, In-Seong Cho, Boyoung Park, Eun-Ha Lee, Soung-Hoon Chang, Hai-Rim Shin, Daehee Kang, Keun-Young Yoo
J Prev Med Public Health. 2012;45(5):301-308.   Published online September 28, 2012
DOI: https://doi.org/10.3961/jpmph.2012.45.5.301
  • 11,835 View
  • 105 Download
  • 16 Crossref
AbstractAbstract PDF
Objectives

To examine the association between alcohol consumption habit, types of beverages, alcohol consumption quantity, and overall and cancer-specific mortality among Korean adults.

Methods

The alcohol consumption information of a total of 16 320 participants who were 20 years or older from the Korean Multi-center Cancer Cohort were analyzed to examine the association between alcohol consumption habit and mortality (median follow-up of 9.3 years). The Cox proportional hazard model was used to estimate the hazard ratio (HR) of alcohol consumption to mortality adjusting for age, sex, geographic areas, education, smoking status, and body mass index.

Results

Alcohol drinkers showed an increased risk for total mortality compared with never drinkers (HR, 1.72; 95% confidence interval [CI], 1.38 to 2.14 for past drinkers; HR, 1.21; 95% CI, 1.06 to 1.39 for current drinkers), while past drinkers only were associated with higher risk for cancer deaths (HR, 1.84; 95% CI, 1.34 to 2.53). The quantity of alcohol consumed per week showed a J-shaped association with risk of mortality. Relative to light drinkers (0.01 to 90 g/wk), never drinkers and heavy drinkers (>504 g/wk) had an increased risk for all-cause and cancer deaths: (HR, 1.18; 95% CI, 0.96 to 1.45) and (HR, 1.39; 95% CI, 1.05 to 1.83) for all-cause mortality; and (HR, 1.55; 95% CI, 1.15 to 2.11) and (HR, 2.07; 95% CI, 1.39 to 3.09) for all cancer mortality, respectively. Heavy drinkers (>504 g/wk) showed an elevated risk for death from stomach and liver cancers.

Conclusions

The present study supports the existence of a J-shaped association between alcohol consumption quantity and the risk of all-cause and cancer deaths. Heavy drinkers had an increased risk of death from cancer overall and liver and stomach cancer.

Summary

Citations

Citations to this article as recorded by  
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    Global Health Promotion.2022; 29(3): 57.     CrossRef
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    In-Ae Song, Hye Yoon Park, Tak Kyu Oh
    Journal of Psychosomatic Research.2022; 161: 111002.     CrossRef
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  • Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer
    Hana Park, Seung Kak Shin, Ijin Joo, Do Seon Song, Jeong Won Jang, Joong-Won Park
    Gut and Liver.2020; 14(6): 792.     CrossRef
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    Mi Hui Kim, Shin Ah Kim, Chan Hyuk Park, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
    Nutrition Research and Practice.2019; 13(5): 425.     CrossRef
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JPMPH : Journal of Preventive Medicine and Public Health