Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Browse Articles > Author index
Search
Geeta Nandyala 1 Article
Exposure to Cerium Oxide Nanoparticles Is Associated With Activation of Mitogen-activated Protein Kinases Signaling and Apoptosis in Rat Lungs
Kevin M. Rice, Siva K. Nalabotu, Nandini D.P.K. Manne, Madhukar B. Kolli, Geeta Nandyala, Ravikumar Arvapalli, Jane Y. Ma, Eric R. Blough
J Prev Med Public Health. 2015;48(3):132-141.   Published online May 18, 2015
DOI: https://doi.org/10.3961/jpmph.15.006
  • 10,241 View
  • 110 Download
  • 21 Crossref
AbstractAbstract PDF
Objectives
With recent advances in nanoparticle manufacturing and applications, potential exposure to nanoparticles in various settings is becoming increasing likely. No investigation has yet been performed to assess whether respiratory tract exposure to cerium oxide (CeO2) nanoparticles is associated with alterations in protein signaling, inflammation, and apoptosis in rat lungs.
Methods
Specific-pathogen-free male Sprague-Dawley rats were instilled with either vehicle (saline) or CeO2 nanoparticles at a dosage of 7.0 mg/kg and euthanized 1, 3, 14, 28, 56, or 90 days after exposure. Lung tissues were collected and evaluated for the expression of proteins associated with inflammation and cellular apoptosis.
Results
No change in lung weight was detected over the course of the study; however, cerium accumulation in the lungs, gross histological changes, an increased Bax to Bcl-2 ratio, elevated cleaved caspase-3 protein levels, increased phosphorylation of p38 MAPK, and diminished phosphorylation of ERK-1/2-MAPK were detected after CeO2 instillation (p<0.05).
Conclusions
Taken together, these data suggest that high-dose respiratory exposure to CeO2 nanoparticles is associated with lung inflammation, the activation of signaling protein kinases, and cellular apoptosis, which may be indicative of a long-term localized inflammatory response.
Summary

Citations

Citations to this article as recorded by  
  • Toxic Effects of Rare Earth Elements on Human Health: A Review
    Wenyu Wang, Yanfang Yang, Donglei Wang, Lihua Huang
    Toxics.2024; 12(5): 317.     CrossRef
  • Blood multiple heavy metals exposure and lung function in young adults: A prospective Cohort study in China
    Minghao Wang, Lailai Yan, Siqi Dou, Liu Yang, Yiwen Zhang, Wenzhong Huang, Shanshan Li, Peng Lu, Yuming Guo
    Journal of Hazardous Materials.2023; 459: 132064.     CrossRef
  • Effects of contaminated surface water and groundwater from a rare earth mining area on the biology and the physiology of Sprague-Dawley rats
    Xiaoying He, Ting Yuan, Xinying Jiang, Hui Yang, Chun Li Zheng
    Science of The Total Environment.2021; 761: 144123.     CrossRef
  • Effects of radiation and role of plants in radioprotection: A critical review
    Mohammed Junaid Hussain Dowlath, Sathish Kumar Karuppannan, Pamela Sinha, Nihala Sultana Dowlath, Kantha Deivi Arunachalam, B. Ravindran, S. Woong Chang, Phuong Nguyen-Tri, D. Duc Nguyen
    Science of The Total Environment.2021; 779: 146431.     CrossRef
  • Methods to evaluate the toxicity of engineered nanomaterials for biomedical applications: a review
    Gaurang Patel, Chayan Patra, S. P. Srinivas, Mamta Kumawat, P. N. Navya, Hemant Kumar Daima
    Environmental Chemistry Letters.2021; 19(6): 4253.     CrossRef
  • Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells
    A. L. Popov, M. A. Abakumov, I. V. Savintseva, A. M. Ermakov, N. R. Popova, O. S. Ivanova, D. D. Kolmanovich, A. E. Baranchikov, V. K. Ivanov
    Journal of Materials Chemistry B.2021; 9(33): 6586.     CrossRef
  • Influence of Ce3+ Substitution on Antimicrobial and Antibiofilm Properties of ZnCexFe2−xO4 Nanoparticles (X = 0.0, 0.02, 0.04, 0.06, and 0.08) Conjugated with Ebselen and Its Role Subsidised with γ-Radiation in Mitigating Human TNBC and Colorectal Adenoca
    Mohamed K. Abdel-Rafei, Noura M. Thabet, M. I. A. Abdel Maksoud, M. Abd Elkodous, Go Kawamura, Atsunori Matsuda, A. H. Ashour, Ahmed I. El-Batal, Gharieb S. El-Sayyad
    International Journal of Molecular Sciences.2021; 22(18): 10171.     CrossRef
  • Protection effect of cerium oxide nanoparticles against radiation-induced acute lung injuries in rats
    Fatemeh Kadivar, Gholamhassan Haddadi, Mohammad Amin Mosleh-Shirazi, Fatemeh Khajeh, Alireza Tavasoli
    Reports of Practical Oncology & Radiotherapy.2020; 25(2): 206.     CrossRef
  • Nanoceria distribution and effects are mouse-strain dependent
    Robert A. Yokel, Michael T. Tseng, D. Allan Butterfield, Matthew L. Hancock, Eric A. Grulke, Jason M. Unrine, Arnold J. Stromberg, Alan K. Dozier, Uschi M. Graham
    Nanotoxicology.2020; 14(6): 827.     CrossRef
  • Cerium Oxide Nanoparticles and Their Importance in Cell Signaling Pathways for Predicting Cellular Behavior
    Atefeh Pesaraklou, Maryam M Matin
    Nanomedicine.2020; 15(17): 1709.     CrossRef
  • Hepatotoxic Effect of Oral Zinc Oxide Nanoparticles and the Ameliorating Role of Selenium in Rats: A histological, immunohistochemical and molecular study
    Basma Emad Aboulhoda, Dina Adel Abdeltawab, Laila Ahmed Rashed, Marwa Fathi Abd Alla, Hanan Dawood Yassa
    Tissue and Cell.2020; 67: 101441.     CrossRef
  • Pulmonary toxicity of inhaled nano-sized cerium oxide aerosols in Sprague–Dawley rats
    Chang Guo, Sarah Robertson, Ralf J. M. Weber, Alison Buckley, James Warren, Alan Hodgson, Joshua Z. Rappoport, Konstantin Ignatyev, Kirsty Meldrum, Isabella Römer, Sameirah Macchiarulo, James Kevin Chipman, Tim Marczylo, Martin O. Leonard, Timothy W. Gant
    Nanotoxicology.2019; 13(6): 733.     CrossRef
  • The first inorganic mitogens: Cerium oxide and cerium fluoride nanoparticles stimulate planarian regeneration via neoblastic activation
    Artem Ermakov, Anton Popov, Olga Ermakova, Olga Ivanova, Alexander Baranchikov, Kristina Kamenskikh, Taisiya Shekunova, Alexander Shcherbakov, Nelli Popova, Vladimir Ivanov
    Materials Science and Engineering: C.2019; 104: 109924.     CrossRef
  • Subchronic toxicity of cerium nitrate by 90-day oral exposure in wistar rats
    Yu Wu, Xiaoqiao Tang, Wenxiang Yang, Jun Fan, Lijun Tang, Chunhong Wang, Zhou Yu, Xu-Dong Jia, Bolin Fan
    Regulatory Toxicology and Pharmacology.2019; 108: 104474.     CrossRef
  • High‐dimensional single cell mapping of cerium distribution in the lung immune microenvironment of an active smoker
    Adeeb H. Rahman, Yonit Lavin, Soma Kobayashi, Andrew Leader, Miriam Merad
    Cytometry Part B: Clinical Cytometry.2018; 94(6): 941.     CrossRef
  • Intranasal Delivery of Copper Oxide Nanoparticles Induces Pulmonary Toxicity and Fibrosis in C57BL/6 mice
    Xiaofeng Lai, Hu Zhao, Yong Zhang, Kai Guo, Yuqiao Xu, Suning Chen, Jian Zhang
    Scientific Reports.2018;[Epub]     CrossRef
  • Nanoparticles Induce Apoptosis Via Mediating Diverse Cellular Pathways
    Liang Chen, Liu-Yun Wu, Wan-Xi Yang
    Nanomedicine.2018; 13(22): 2939.     CrossRef
  • Zinc Oxide Nanoparticle–Poly I:C RNA Complexes: Implication as Therapeutics against Experimental Melanoma
    Meghana Ramani, Miranda C. Mudge, R. Tyler Morris, Yuntao Zhang, Stanislaw A. Warcholek, Miranda N. Hurst, Jim E. Riviere, Robert K. DeLong
    Molecular Pharmaceutics.2017; 14(3): 614.     CrossRef
  • Fine Particulate Matter and Sulfur Dioxide Coexposures Induce Rat Lung Pathological Injury and Inflammatory Responses Via TLR4/p38/NF-κB Pathway
    Ruijin Li, Lifang Zhao, Jinlong Tong, Yuchao Yan, Chong Xu
    International Journal of Toxicology.2017; 36(2): 165.     CrossRef
  • Anti-inflammatory and antioxidant effect of cerium dioxide nanoparticles immobilized on the surface of silica nanoparticles in rat experimental pneumonia
    Z. Serebrovska, R.J. Swanson, V. Portnichenko, A. Shysh, S. Pavlovich, L. Tumanovska, A. Dorovskych, V. Lysenko, V. Tertykh, Y. Bolbukh, V. Dosenko
    Biomedicine & Pharmacotherapy.2017; 92: 69.     CrossRef
  • Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats
    Daniela Schwotzer, Heinrich Ernst, Dirk Schaudien, Heiko Kock, Gerhard Pohlmann, Clemens Dasenbrock, Otto Creutzenberg
    Particle and Fibre Toxicology.2017;[Epub]     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health
TOP