- Coping Mechanisms Utilized by Individuals With Drug Addiction in Overcoming Challenges During the Recovery Process: A Qualitative Meta-synthesis
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Agus Setiawan, Junaiti Sahar, Budi Santoso, Muchtaruddin Mansyur, Syamikar Baridwan Syamsir
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J Prev Med Public Health. 2024;57(3):197-211. Published online May 3, 2024
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DOI: https://doi.org/10.3961/jpmph.24.042
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 Abstract
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- Objectives
Recovery from drug addiction often poses challenges for the recovering person. The coping mechanisms employed by these individuals to resist temptations and manage stress play a key role in the healing process. This study was conducted to explore the coping strategies or techniques that individuals with addiction use to handle stress and temptation while undergoing treatment.
Methods
A qualitative meta-synthesis approach was utilized to critically evaluate relevant qualitative research. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines were used for article selection, with these standards applied to 4 academic databases: Scopus, PubMed, ProQuest, and CINAHL. The present review included studies published between 2014 and 2023, selected based on pre-established inclusion criteria. The quality of the studies was assessed using the Critical Appraisal Skills Programme Qualitative Studies Checklist. This review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) under the registration number CRD42024497789.
Results
The analysis of 13 qualifying qualitative articles revealed 5 major themes illustrating the coping mechanisms employed in the pursuit of recovery by individuals who use drugs. These themes include seeking social support, as well as psychological coping strategies, spiritual experiences, professional interventions, and the enhancement of awareness.
Conclusions
Among individuals with drug addiction, coping mechanisms are crucial for resisting stress and temptations throughout the recovery process. Healthcare professionals, as medical specialists, can establish more thorough and effective plans to support these patients on their path to recovery.
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Summary
Key Message
This study attempts to investigate the coping mechanisms used by individuals with drug addiction during the recovery process. Through a qualitative meta-synthesis of 13 qualitative studies, we identified five main coping mechanisms: seeking social support, psychological coping strategies, spiritual experiences, professional interventions, and the enhancement of awareness. These results suggest that these coping mechanisms are important for managing stress and temptation, supporting a more holistic approach to addiction treatment.
- The Role of CYP2B6*6 Gene Polymorphisms in 3,5,6-Trichloro-2-pyridinol Levels as a Biomarker of Chlorpyrifos Toxicity Among Indonesian Farmers
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Jen Fuk Liem, Dwi A. Suryandari, Safarina G. Malik, Muchtaruddin Mansyur, Dewi S. Soemarko, Aria Kekalih, Imam Subekti, Franciscus D. Suyatna, Bertha Pangaribuan
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J Prev Med Public Health. 2022;55(3):280-288. Published online May 16, 2022
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DOI: https://doi.org/10.3961/jpmph.21.641
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Abstract
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 Supplementary Material
- Objectives
One of the most widely used pesticides today is chlorpyrifos (CPF). Cytochrome P450 (CYP)2B6, the most prominent catalyst in CPF bioactivation, is highly polymorphic. The objective of our study was to evaluate the role of CYP2B6*6, which contains both 516G>T and 785A>G polymorphisms, in CPF toxicity, as represented by the concentration of 3,5,6-trichloro-2-pyridinol (TCPy), among vegetable farmers in Central Java, Indonesia, where CPF has been commonly used.
Methods
A cross-sectional study was conducted among 132 vegetable farmers. Individual socio-demographic and occupational characteristics, as determinants of TCPy levels, were obtained using a structured interviewer-administered questionnaire and subsequently used to estimate the cumulative exposure level (CEL). TCPy levels were detected with liquid chromatography-mass spectrometry. CYP2B6*6 gene polymorphisms were analyzed using a TaqMan® SNP Genotyping Assay and Sanger sequencing. Linear regression analysis was performed to analyze the association between TCPy, as a biomarker of CPF exposure, and its determinants.
Results
The prevalence of CYP2B6*6 polymorphisms was 31% for *1/*1, 51% for *1/*6, and 18% for *6/*6. TCPy concentrations were higher among participants with CYP2B6*1/*1 than among those with *1/*6 or *6/*6 genotypes. CYP2B6*6 gene polymorphisms, smoking, CEL, body mass index, and spraying time were retained in the final linear regression model as determinants of TCPy.
Conclusions
The results suggest that CYP2B6*6 gene polymorphisms may play an important role in influencing susceptibility to CPF exposure. CYP2B6*6 gene polymorphisms together with CEL, smoking habits, body mass index, and spraying time were the determinants of urinary TCPy concentrations, as a biomarker of CPF toxicity.
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Summary
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Citations
Citations to this article as recorded by  - Human CYP2C19 Substrate and Inhibitor Characterization of Organophosphate Pesticides
Patricia A. Vignaux, Pratik Shriwas, Andre Revnew, Garima Agarwal, Thomas R. Lane, Craig A. McElroy, Sean Ekins
Chemical Research in Toxicology.2023; 36(9): 1451. CrossRef - The determinants of thyroid function among vegetable farmers with primary exposure to chlorpyrifos: A cross-sectional study in Central Java, Indonesia
Jen Fuk Liem, Imam Subekti, Muchtaruddin Mansyur, Dewi S. Soemarko, Aria Kekalih, Franciscus D. Suyatna, Dwi A. Suryandari, Safarina G. Malik, Bertha Pangaribuan
Heliyon.2023; 9(6): e16435. CrossRef
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