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Song Vogue Ahn 7 Articles
C-reactive Protein Concentration Is Associated With a Higher Risk of Mortality in a Rural Korean Population
Jung Hyun Lee, Hyungseon Yeom, Hyeon Chang Kim, Il Suh, Mi Kyung Kim, Min-Ho Shin, Dong Hoon Shin, Sang-Baek Koh, Song Vogue Ahn, Tae-Yong Lee, So Yeon Ryu, Jae-Sok Song, Hong-Soon Choe, Young-Hoon Lee, Bo Youl Choi
J Prev Med Public Health. 2016;49(5):275-287.   Published online August 23, 2016
DOI: https://doi.org/10.3961/jpmph.16.025
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AbstractAbstract PDFSupplementary Material
Objectives
C-reactive protein (CRP), an inflammatory biomarker, has been widely used as a preclinical marker predictive of morbidity and mortality. Although many studies have reported a positive association between CRP and mortality, uncertainty still remains about this association in various populations, especially in rural Korea.
Methods
A total of 23 233 middle-aged participants (8862 men and 14 371 women) who were free from cardiovascular disease, cancer, and acute inflammation (defined by a CRP level ≥10 mg/L) were drawn from 11 rural communities in Korea between 2005 and 2011. Blood CRP concentration was analyzed as a categorical variable (low: 0.0-0.9 mg/L; intermediate: 1.0-3.0 mg/L; high: 3.1-9.9 mg/L) as well as a continuous variable. Each participant’s vital status through December 2013 was confirmed by death statistics from the National Statistical Office. Cox proportional hazard models were used to assess the independent association between CRP and mortality after adjusting for other risk factors.
Results
The total quantity of observed person-years was 57 975 for men and 95 146 for women, and the number of deaths was 649 among men and 367 among women. Compared to the low-CRP group, the adjusted hazard ratio for all-cause mortality of the intermediate group was 1.17 (95% confidence interval [CI], 0.98 to 1.40) for men and 1.27 (95% CI, 1.01 to 1.61) for women, and the corresponding values for the high-CRP group were 1.98 (95% CI, 1.61 to 2.42) for men and 1.41 (95% CI, 1.03 to 1.95) for women. Similar trends were found for CRP evaluated as a continuous variable and for cardiovascular mortality.
Conclusions
Higher CRP concentrations were associated with higher mortality in a rural Korean population, and this association was more prominent in men than in women.
Summary

Citations

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  • Binary cutpoint and the combined effect of systolic and diastolic blood pressure on cardiovascular disease mortality: A community-based cohort study
    Ju-Yeun Lee, Ji Hoon Hong, Sangjun Lee, Seokyung An, Aesun Shin, Sue K. Park, Tariq Jamal Siddiqi
    PLOS ONE.2022; 17(6): e0270510.     CrossRef
  • Association of serum high-sensitivity C reactive protein with risk of mortality in an Asian population: the Health Examinees cohort
    Sang-Ah Lee, Sung Ok Kwon, Hyerim Park, Xiao-Ou Shu, Jong-Koo Lee, Daehee Kang
    BMJ Open.2022; 12(7): e052630.     CrossRef
  • Associations of C-reactive protein and fibrinogen with mortality from all-causes, cardiovascular disease and cancer among U.S. adults
    Junxiu Liu, Yanan Zhang, Carl J. Lavie, Fred K. Tabung, Jiting Xu, Qingwei Hu, Lixia He, Yunxiang Zhang
    Preventive Medicine.2020; 139: 106044.     CrossRef
  • Sex differences in the association between self-rated health and high-sensitivity C-reactive protein levels in Koreans: a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey
    Se-Won Park, Seong-Sik Park, Eun-Jung Kim, Won-Suk Sung, In-Hyuk Ha, Boyoung Jung
    Health and Quality of Life Outcomes.2020;[Epub]     CrossRef
Association Between Meat Consumption and Carotid Intima-Media Thickness in Korean Adults with Metabolic Syndrome.
Sun Min Oh, Hyeon Chang Kim, Song Vogue Ahn, Hye Jin Chi, Il Suh
J Prev Med Public Health. 2010;43(6):486-495.
DOI: https://doi.org/10.3961/jpmph.2010.43.6.486
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  • 10 Crossref
AbstractAbstract PDF
OBJECTIVES
The effect of meat consumption on cardiometabolic risk has been continuously studied, but their associations are not conclusive. The aim of this study is to examine the association between the consumption of meat or red meat and carotid intima-media thickness (IMT) in healthy Korean adults. METHODS: This study evaluated 2374 community-dwelling adults (933 men and 1441 women) who were free of cardiovascular disease or cancer, living in a rural area in Korea. Total meat and red meat intakes were assessed with a validated 103 item-food frequency questionnaire. Carotid IMT was evaluated ultrasonographically, IMTmax was defined as the highest value among IMT of bilateral common carotid arteries. RESULTS: After adjustment for potential confounding factors, the mean IMTmax tended to increase in higher meat consumption groups in both men and women with metabolic syndrome (p for trend= 0.027 and 0.049, respectively), but not in participants without metabolic syndrome. Frequent meat consumption (> or =5 servings/week) was significantly associated with higher IMTmax in men with metabolic syndrome (by 0.08 mm, p=0.015). Whereas, the association was not significant in women (by 0.05 mm, p=0.115). Similar but attenuated findings were shown with red meat intake. CONCLUSIONS: Our findings suggest that a higher meat consumption may be associated with a higher carotid IMT in Korean adults with metabolic syndrome. The frequent meat consumption (> or =5 servings/week), compared with the others, was associated with a higher carotid IMTmax only in men with metabolic syndrome. Further research is required to explore optimal meat consumption in people with specific medical conditions.
Summary

Citations

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  • Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants
    Federica Laguzzi, Buamina Maitusong, Rona J. Strawbridge, Damiano Baldassarre, Fabrizio Veglia, Steve E. Humphries, Rainer Rauramaa, Sudhir Kurl, Andries J. Smit, Philippe Giral, Angela Silveira, Elena Tremoli, Anders Hamsten, Ulf de Faire, Bruna Gigante,
    Scientific Reports.2021;[Epub]     CrossRef
  • The Relationship Between Dietary Choices and Health and Premature Vascular Ageing
    Ioana Mozos, Daniela Jianu, Dana Stoian, Costin Mozos, Cristina Gug, Marius Pricop, Otilia Marginean, Constantin Tudor Luca
    Heart, Lung and Circulation.2021; 30(11): 1647.     CrossRef
  • Relation between the Total Diet Quality based on Korean Healthy Eating Index and the Incidence of Metabolic Syndrome Constituents and Metabolic Syndrome among a Prospective Cohort of Korean Adults
    Saerom Shin, Seungmin Lee
    Korean Journal of Community Nutrition.2020; 25(1): 61.     CrossRef
  • Association between Total Diet Quality and Metabolic Syndrome Incidence Risk in a Prospective Cohort of Korean Adults
    Saerom Shin, Seungmin Lee
    Clinical Nutrition Research.2019; 8(1): 46.     CrossRef
  • Red meat consumption and cardiovascular target organ damage (from the Strong Heart Study)
    Bernhard Haring, Wenyu Wang, Amanda Fretts, Daichi Shimbo, Elisa T. Lee, Barbara V. Howard, Mary J. Roman, Richard B. Devereux
    Journal of Hypertension.2017; 35(9): 1794.     CrossRef
  • The Strong Heart Study
    José R. Banegas, Fernando Rodríguez-Artalejo
    Journal of Hypertension.2017; 35(9): 1782.     CrossRef
  • Association between Nitrogen Stable Isotope Ratios in Human Hair and Serum Levels of Leptin
    Song Vogue Ahn, Sang-Baek Koh, Kwang-Sik Lee, Yeon-Sik Bong, Jong-Ku Park
    The Tohoku Journal of Experimental Medicine.2017; 243(2): 133.     CrossRef
  • The association between carbon and nitrogen stable isotope ratios of human hair and metabolic syndrome
    Jong-Ku Park, Song Vogue Ahn, Mi Kyung Kim, Kwang-Sik Lee, Sang-Baek Koh, Yeon-Sik Bong
    Clinica Chimica Acta.2015; 450: 72.     CrossRef
  • Mediterranean diet and carotid atherosclerosis in the Northern Manhattan Study
    Hannah Gardener, Clinton B. Wright, Digna Cabral, Nikolaos Scarmeas, Yian Gu, Ken Cheung, Mitchell S.V. Elkind, Ralph L. Sacco, Tatjana Rundek
    Atherosclerosis.2014; 234(2): 303.     CrossRef
  • Association Between Serum Uric Acid Level and Metabolic Syndrome
    Ju-Mi Lee, Hyeon Chang Kim, Hye Min Cho, Sun Min Oh, Dong Phil Choi, Il Suh
    Journal of Preventive Medicine and Public Health.2012; 45(3): 181.     CrossRef
C-reactive Protein and Carotid Intima-media Thickness in a Population of Middle-aged Koreans.
Mina Suh, Joo Young Lee, Song Vogue Ahn, Hyeon Chang Kim, Il Suh
J Prev Med Public Health. 2009;42(1):29-34.
DOI: https://doi.org/10.3961/jpmph.2009.42.1.29
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  • 3 Crossref
AbstractAbstract PDF
OBJECTIVES
This study was performed to evaluate the relationship between C-reactive protein (CRP) and carotid intima-media thickness (carotid IMT) in a population of middle-aged Koreans. METHODS: A total of 1,054 men and 1,595 women (aged 40-70 years) from Kanghwa County, Korea, were chosen for the present study between 2006 and 2007. We measured high-sensitivity CRP and other major cardiovascular risk factors including anthropometrics, blood pressure, blood chemistry, and carotid ultrasonography. Health related questionnaires were also completed by each study participant. Carotid IMT value was determined by the maximal IMT at each common carotid artery. The relationship between CRP level and carotid IMT was assessed using multiple linear and logistic regression models after adjustment for age, body mass index, menopause (women), systolic blood pressure, total/HDL cholesterol ratio, triglyceride level, fasting glucose, smoking, and alcohol consumption. RESULTS: Mean carotid IMT values from the lowest to highest quartile of CRP were 0.828, 0.873, 0.898, and 0.926 mm for women (p for trend<0.001), and 0.929, 0.938, 0.949, and 0.979 mm for men (p for trend=0.032), respectively. After adjustment for major cardiovascular risk factors, the relationship between CRP and carotid IMT was significant in women (p for trend=0.017), but not in men (p for trend=0.798). Similarly, adjusted odds ratio of increased IMT, defined as the sex-specific top quartile, for the highest versus lowest CRP quartiles was 1.55 (95% CI=1.06-2.26) in women, but only 1.05 (95% CI=0.69-1.62) in men. CONCLUSIONS: CRP and carotid IMT levels appear to be directly related in women, but not in men.
Summary

Citations

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  • Hematocrit Values Predict Carotid Intimal-Media Thickness in Obese Patients With Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study
    Giovanni Tarantino, Luigi Barrea, Domenico Capone, Vincenzo Citro, Teresa Mosca, Silvia Savastano
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Association Between Serum Uric Acid Level and Metabolic Syndrome
    Ju-Mi Lee, Hyeon Chang Kim, Hye Min Cho, Sun Min Oh, Dong Phil Choi, Il Suh
    Journal of Preventive Medicine and Public Health.2012; 45(3): 181.     CrossRef
  • Relationships between high-sensitive C-reactive protein and markers of arterial stiffness in hypertensive patients. Differences by sex
    Manuel A Gomez-Marcos, Jose I Recio-Rodríguez, Maria C Patino-Alonso, Cristina Agudo-Conde, Leticia Gomez-Sanchez, Emiliano Rodriguez-Sanchez, Marta Gomez-Sanchez, Vicente Martinez-Vizcaino, Luis Garcia-Ortiz
    BMC Cardiovascular Disorders.2012;[Epub]     CrossRef
Association between Hypertension and Pulmonary Function in Rural Adults in Korea.
Joo Young Lee, Song Vogue Ahn, Dong Phil Choi, Mina Suh, Hyeon Chang Kim, Young Sam Kim, Il Suh
J Prev Med Public Health. 2009;42(1):21-28.
DOI: https://doi.org/10.3961/jpmph.2009.42.1.21
  • 5,517 View
  • 77 Download
  • 6 Crossref
AbstractAbstract PDF
OBJECTIVES
Whilst hypertension exerts a negative effect on several organs there have been few studies regarding its effect on pulmonary function. The objective of this study was to examine the relationship between hypertension and pulmonary function in rural Korean adults. METHODS: In 2006, 2534 people were recruited, aged 40 to 70, in Kangwha County. We selected 1454 (male: 624, female: 830) participants whose pulmonary function results were repeatable. Blood pressure (BP) was measured twice and the average calculated. Participants were divided into two groups (hypertensive group and non-hypertensive group) in accordance with The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Pulmonary function was measured by dry rolling seal spirometry. Forced expiratory volume in the one second and forced vital capacity were converted into percent-predicted values based on average pulmonary function amongst Koreans. RESULTS: The number of hypertensive participants in the present study was 460 (male: 205, female: 255) and the number of non-hypertensive participants was 994 (male: 419, female: 575). Our findings have shown that the mean values for expiratory volume in the one second and forced vital capacity were significantly lower for hypertensive people than for non-hypertensive people, among women (P=0.002 for forced expiratory volume in the one second, P<0.001 for forced vital capacity volume). Odds ratio analysis revealed that hypertensive participants were more likely to have lower pulmonary function than non-hypertensive participants, again significantly among women. CONCLUSIONS: The pulmonary function of hypertensive women was significantly lower than that of non-hypertensive women aged 40-70.
Summary

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  • Comparison between Tai Chi and square dance on the antihypertensive effect and cardiovascular disease risk factors in patients with essential hypertension: a 12-week randomized controlled trial
    Zhi-Wei YAN, Zhen YANG, Jing-Hui YANG, Cheng-Lin SONG, Zhuang ZHAO, Yan GAO
    The Journal of Sports Medicine and Physical Fitness.2022;[Epub]     CrossRef
  • The association between the metabolic syndrome and metabolic syndrome score and pulmonary function in non-smoking adults
    Hyun Yoon, Mi Young Gi, Ju Ae Cha, Chan Uk Yoo, Sang Muk Park
    Diabetes and Vascular Disease Research.2018; 15(2): 131.     CrossRef
  • Cardiovascular disease risk in people with spinal cord injury: is there a possible association between reduced lung function and increased risk of diabetes and hypertension?
    B F Köseoğlu, V B Safer, Ö Öken, S Akselim
    Spinal Cord.2017; 55(1): 87.     CrossRef
  • Association between changes in systolic blood pressure and incident diabetes in a community-based cohort study in Korea
    Seung Won Lee, Hyeon Chang Kim, Ju-mi Lee, Young Mi Yun, Joo Young Lee, Il Suh
    Hypertension Research.2017; 40(7): 710.     CrossRef
  • Association between stressful life events and resting heart rate
    Ju-Mi Lee, Hyeon Chang Kim, Jee In Kang, Il Suh
    BMC Psychology.2014;[Epub]     CrossRef
  • Association Between Serum Uric Acid Level and Metabolic Syndrome
    Ju-Mi Lee, Hyeon Chang Kim, Hye Min Cho, Sun Min Oh, Dong Phil Choi, Il Suh
    Journal of Preventive Medicine and Public Health.2012; 45(3): 181.     CrossRef
Impact of Multiple Cardiovascular Risk Factors on the Carotid Intima-media Thickness in Young Adults: The Kangwha Study.
Hoo Sun Chang, Hyeon Chang Kim, Song Vogue Ahn, Nam Wook Hur, Il Suh
J Prev Med Public Health. 2007;40(5):411-417.
DOI: https://doi.org/10.3961/jpmph.2007.40.5.411
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AbstractAbstract PDF
OBJECTIVES
Although risk factors for coronary artery disease are also associated with increased carotid intima-media thickness (IMT), there is little information available on the asymptomatic, young adult population. We examined the association between multiple cardiovascular risk factors and the common carotid IMT in 280 young Korean adults. METHODS: The data used for this study was obtained from 280 subjects (130 men and 150 women) aged 25 years who participated in the Kangwha Study follow-up examination in 2005. We measured cardiovascular risk factors, including anthropometrics, blood pressure, blood chemistry, carotid ultrasonography, and reviewed questionnaires on health behaviors. Risk factors were defined as values above the sex-specific 75th percentile of systolic blood pressure, body mass index, total cholesterol/high-density lipoprotein cholesterol ratio, fasting blood glucose and smoking status. RESULTS: The mean carotid IMT+/-standard deviation observed was 0.683+/-0.079 mm in men and 0.678+/-0.067 mm in women (p=0.567) and the evidence of plaque was not observed in any individuals. Mean carotid IMT increased with an increasing number of risk factors(p for trend <0.001) and carotid IMT values were 0.665 mm, 0.674 mm, 0.686 mm, 0.702 mm, and 0.748 mm for 0, 1, 2, 3, and 4 to 5 risk factors, respectively. The odds ratio for having the top quartile carotid IMT in men with 3 or more risk factors versus 0-2 risk factors was 5.09 (95% CI, 2.05-12.64). CONCLUSIONS: Current findings indicate the need for prevention and control of cardiovascular risk factors in young adults and more focus on those with multiple cardiovascular risk factors.
Summary

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  • Association Between Risk Factors in Childhood and Sex Differences in Prevalence of Carotid Artery Plaques and Intima‐Media Thickness in Mid‐Adulthood in the Childhood Determinants of Adult Health Study
    Mohammad Shah, Marie‐Jeanne Buscot, Jing Tian, Hoang T. Phan, Brooklyn J. Fraser, Thomas H. Marwick, Terence Dwyer, Alison Venn, Seana Gall
    Journal of the American Heart Association.2023;[Epub]     CrossRef
  • Association between Fibrinogen and Carotid Atherosclerosis According to Smoking Status in a Korean Male Population
    Hye Min Cho, Dae Ryong Kang, Hyeon Chang Kim, Sun Min Oh, Byeong-Keuk Kim, Il Suh
    Yonsei Medical Journal.2015; 56(4): 921.     CrossRef
  • Myocardial perfusion and intima-media thickness in patients with subclinical hypothyroidism
    M Knapp, A Lisowska, B Sobkowicz, A Tycińska, R Sawicki, WJ Musiał
    Advances in Medical Sciences.2013; 58(1): 44.     CrossRef
  • Association between Depressive Symptoms and Bone Stiffness Index in Young Adults: The Kangwha Study
    Sun Min Oh, Hyeon Chang Kim, Kyoung Min Kim, Song Vogue Ahn, Dong Phil Choi, Il Suh, Chih-Hsin Tang
    PLoS ONE.2013; 8(7): e69929.     CrossRef
  • The importance of intima-media thickness (IMT) measurements in monitoring of atherosclerosis progress after myocardial infarction
    A Lisowska, M Knapp, S Bolińska, P Lisowski, A Krajewska, B Sobkowicz, WJ Musiał
    Advances in Medical Sciences.2012; 57(1): 112.     CrossRef
  • Association between Blood Pressure and Carotid Intima-Media Thickness
    Sun Min Lim, Hyeon Chang Kim, Hoon Sang Lee, Joo Young Lee, Mina Suh, Song Vogue Ahn
    The Journal of Pediatrics.2009; 154(5): 667.     CrossRef
Relationship between Corrected QT Interval and Cardiovascular Risk Factors in Young Healthy Adults: The Kangwha Study.
Song Vogue Ahn, Hyeon Chang Kim, Nam Wook Hur, Kyoung Soo Ha, Hoo Sun Jang, Jin Bae Kim, Il Suh
J Prev Med Public Health. 2006;39(6):455-461.
  • 2,315 View
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AbstractAbstract PDF
OBJECTIVES
Prolongation of the heart rate-corrected QT (QTc) interval has been reported to be associated with cardiovascular morbidity and mortality. However, few studies have examined the relationship between the QTc interval and cardiovascular risk factors in young healthy people. The aim of this study was to examine the associations between the QTc interval and cardiovascular risk factors in young healthy adults. METHODS: This study was performed as part of the Kangwha study, which started in 1986, and is an on-going follow-up study on blood pressure and related cardiovascular risk factors. In follow-up examinations during 2005, cardiovascular risk factors, including anthropometrics, blood pressure, blood chemistry and carotid ultrasonography, were measured, and questionnaires on health behaviors completed by 127 men and 149 women aged 25 years. The QTc interval was measured on the resting 12-lead electrocardiogram using an automatic analysis program. RESULTS: The mean QTc interval was significantly longer in women (419+/-17ms) than in men (405+/-17ms) (p<0.001). A significant positive correlation was found between the QTc interval and waist-hip ratio (p=0.030) in men. Women showed a positive correlation between the QTc interval and systolic blood pressure (p=0.017). On a multiple regression analysis, the QTc interval was positively associated with the waist-hip ratio in men (p=0.012) and with the systolic blood pressure (p=0.020) in women. CONCLUSIONS: In young healthy Korean adults, the QTc interval was independently associated with the waist-hip ratio in men and with the systolic blood pressure in women.
Summary
Dipstick Urine Protein, as a Predictor of Cardiovascular Mortality in Korean Men: Korea Medical Insurance Corporation Study.
Kyoungsoo Ha, Hyeon Chang Kim, Dae Ryong Kang, Chung Mo Nam, Song Vogue Ahn, Il Suh
J Prev Med Public Health. 2006;39(5):427-432.
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AbstractAbstract PDF
OBJECTIVES
This study was to investigate if the dipstick proteinuria can predict cardiovascular mortality in a population of Korean men. METHODS: We measured urine protein and other cardiovascular risk factors in 100059 Korean men, aged between 35-59 years in 1990 and 1992. Levels of proteinuria measured by dipstick method were trace or less, 1+, 2+, and 3+ or greater. The primary outcomes were deaths from all causes, cardiovascular disease, cancer, and others in a 12 year follow-up from 1993 to 2004. RESULTS: The multivariate-adjusted relative risks (95% CI) for cardiovascular death according to the level of proteinuria (1+, 2+, 3+ and more) in 1990 examination were 2.18 (1.36-3.48), 2.55 (1.37-4.78), and 4.57 (2.16-9.66) respectively. The corresponding relative risks according to the level of proteinuria in 1992 examination were 2.49 (1.71-3.64), 2.64 (1.53-4.58), and 2.78 (1.15-6.73). The relative risks for cardiovascular death of men with proteinuria (1+ or greater) once and twice among the examinations were 2.18 (1.63-2.92) and 3.75 (2.27-6.18), compared with men without proteinuria in 1990 and 1992 examinations. CONCLUSIONS: Our results showed that dipstick proteinuria is associated with cardiovascular mortality in Korean men. Dipstick proteinuria could be a predictor for cardiovascular mortality.
Summary

JPMPH : Journal of Preventive Medicine and Public Health