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Original Article
- Modeling Survival in Patients With Brain Stroke in the Presence of Competing Risks
- Solmaz Norouzi, Mohammad Asghari Jafarabadi, Seyed Morteza Shamshirgaran, Farshid Farzipoor, Ramazan Fallah
- J Prev Med Public Health. 2021;54(1):55-62. Published online December 7, 2020
- DOI: https://doi.org/10.3961/jpmph.20.463
- 6,029 View
- 143 Download
- 4 Web of Science
- 3 Crossref
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Abstract
PDF - Objectives
After heart disease, brain stroke (BS) is the second most common cause of death worldwide, underscoring the importance of understanding preventable and treatable risk factors for the outcomes of BS. This study aimed to model the survival of patients with BS in the presence of competing risks.
Methods
This longitudinal study was conducted on 332 patients with a definitive diagnosis of BS. Demographic characteristics and risk factors were collected by a validated checklist. Patients’ mortality status was investigated by telephone follow-up to identify deaths that may be have been caused by stroke or other factors (heart disease, diabetes, high cholesterol, etc.). Data were analyzed by the Lunn-McNeil approach at alpha=0.1.
Results
Older age at diagnosis (59-68 years: adjusted hazard ratio [aHR], 2.19; 90% confidence interval [CI], 1.38 to 3.48; 69-75 years: aHR, 5.04; 90% CI, 3.25 to 7.80; ≥76 years: aHR, 5.30; 90% CI, 3.40 to 8.44), having heart disease (aHR, 1.65; 90% CI, 1.23 to 2.23), oral contraceptive pill use (women only) (aHR, 0.44; 90% CI, 0.24 to 0.78) and ischemic stroke (aHR, 0.52; 90% CI, 0.36 to 0.74) were directly related to death from BS. Older age at diagnosis (59-68 years: aHR, 21.42; 90% CI, 3.52 to 130.39; 75-69 years: aHR, 16.48; 90% CI, 2.75 to 98.69; ≥76 years: aHR, 26.03; 90% CI, 4.06 to 166.93) and rural residence (aHR, 2.30; 90% CI, 1.15 to 4.60) were directly related to death from other causes. Significant risk factors were found for both causes of death.
Conclusions
BS-specific and non-BS-specific mortality had different risk factors. These findings could be utilized to prescribe optimal and specific treatment. -
Summary
Citations
Citations to this article as recorded by
- Deep neural network base competing risk in predicting heart failure patient’s survival
Solmaz Norouzi, Ebrahim Hajizadeh, Mohammad Asghari Jafarabadi, Nasim Naderi, Saeideh Mazloomzadeh
Journal of Diabetes & Metabolic Disorders.2025;[Epub] CrossRef - Body mass index and all-cause mortality in US stroke population: a cohort study
Chenyan Yue, Huisheng Dong, Anmu Xie, Jing Wang
BMC Neurology.2025;[Epub] CrossRef - Weight Change and Ischemic Stroke Risk among Participants in the Atherosclerosis Risk in Communities Study
Logan Cowan, Joana Tome, Cyrille Kouambo Beckodro, Pamela Lutsey, Kamakshi Lakshminarayan, Michelle Johansen, Jakita Baldwin
Neuroepidemiology.2025; : 1. CrossRef
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