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Hormonal Replacement Therapy and the Risk of Lung Cancer in Women: An Adaptive Meta-analysis of Cohort Studies
Jong-Myon Bae, Eun Hee Kim
J Prev Med Public Health. 2015;48(6):280-286.   Published online November 9, 2015
DOI: https://doi.org/10.3961/jpmph.15.054
  • 13,105 View
  • 124 Download
  • 26 Crossref
AbstractAbstract PDF
Objectives
Approximately 10% to 15% of lung cancer cases occur in never-smokers. Hormonal factors have been suggested to lead to an elevated risk of lung cancer in women. This systematic review (SR) aimed to investigate the association between hormonal replacement therapy (HRT) and the risk of lung cancer in women using cohort studies.
Methods
We first obtained previous SR articles on this topic. Based on these studies we made a list of refereed, cited, and related articles using the PubMed and Scopus databases. All cohort studies that evaluated the relative risk of HRT exposure on lung cancer occurrence in women were selected. Estimate of summary effect size (sES) with 95% confidence intervals (CIs) were calculated.
Results
A total of 14 cohort studies were finally selected. A random effect model was applied due to heterogeneity (I-squared, 64.3%). The sES of the 14 articles evaluating the impact of HRT exposure on lung cancer occurrence in women indicated no statistically significant increase in lung cancer risk (sES, 0.99; 95% CI, 0.90 to 1.09).
Conclusions
These results showed that HRT history had no effect on the risk of lung cancer in women, even though the sES of case-control studies described in previous SR articles indicated that HRT had a protective effect against lung cancer. It is necessary to conduct a pooled analysis of cohort studies.
Summary

Citations

Citations to this article as recorded by  
  • Reproductive factors and risk of lung cancer among 300,000 Chinese female never-smokers: evidence from the China Kadoorie Biobank study
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    Lisa Rancan, Angela Puig, José M. Balibrea, Sergio D. Paredes, Cruz García, Luis Jiménez, Jesús A. Fernández-Tresguerres, Elena Vara
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    The Journal of Thoracic and Cardiovascular Surgery.2020; 159(4): 1546.     CrossRef
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    The Journals of Gerontology: Series A.2019; 74(5): 675.     CrossRef
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    Medicine.2019; 98(51): e17532.     CrossRef
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    Menopause.2018; 25(11): 1362.     CrossRef
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  • Epidemiology of Second Primary Tumors in Women With Ovarian Cancer
    Tomi T. Kanninen, Dimitrios Nasioudis, Giovanni Sisti, Kevin Holcomb, Mariarosaria Di Tommaso, Susan Khalil, Anar Gojayev, Steven S. Witkin
    International Journal of Gynecologic Cancer.2017; 27(4): 659.     CrossRef
  • The 2017 hormone therapy position statement of The North American Menopause Society

    Menopause.2017; 24(7): 728.     CrossRef
  • Citation Discovery Tools for Conducting Adaptive Meta-analyses to Update Systematic Reviews
    Jong-Myon Bae, Eun Hee Kim
    Journal of Preventive Medicine and Public Health.2016; 49(2): 129.     CrossRef
  • Osteoporosis: Modern Paradigms for Last Century’s Bones
    Marlena Kruger, Frances Wolber
    Nutrients.2016; 8(6): 376.     CrossRef
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    Carol L. Kuhle, Ekta Kapoor, Richa Sood, Jacqueline M. Thielen, Aminah Jatoi, Stephanie S. Faubion
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  • Dietary intakes of citrus fruit and risk of gastric cancer incidence: an adaptive meta-analysis of cohort studies
    Jong-Myon Bae, Eun Hee Kim
    Epidemiology and Health.2016; 38: e2016034.     CrossRef
  • Modifiable risk factors of lung cancer in “never-smoker” women
    Jong-Myon Bae
    Epidemiology and Health.2015; 37: e2015047.     CrossRef
  • Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis
    Jong-Myon Bae, Eun Hee Kim
    Epidemiology and Health.2015; 37: e2015052.     CrossRef
Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review
Jong-Myon Bae, Eun Hee Kim
J Prev Med Public Health. 2015;48(5):225-230.   Published online September 16, 2015
DOI: https://doi.org/10.3961/jpmph.15.046
  • 13,632 View
  • 167 Download
  • 18 Crossref
AbstractAbstract PDF
Objectives
The epidemiological characteristics of breast cancer incidence by age group in Korean women are unique. This systematic review aimed to investigate the association between hormone replacement therapy (HRT) and breast cancer risk in Korean women.
Methods
We searched electronic databases such as KoreaMed, KMbase, KISS, and RISS4U as well as PubMed for publications on Korean breast cancer patients. We also conducted manual searching based on references and citations in potential papers. All of the analytically epidemiologic studies that obtained individual data on HRT exposure and breast cancer occurrence in Korean women were selected. We restricted the inclusion of case-control studies to those that included age-matched controls. Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models.
Results
One cohort and five case-control studies were finally selected. Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied. The summary effect size of HRT history from the six articles indicated no statistical significance in breast cancer risk (SOR, 0.983; 95% CI, 0.620 to 1.556).
Conclusions
These facts support no significant effect of HRT history in the risk of breast cancer in Korean women. It is necessary to conduct a pooled analysis.
Summary

Citations

Citations to this article as recorded by  
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