Journal of Preventive Medicine and Public Health

Original Article

Regimen-related Mortality Risk in Patients Undergoing Peritoneal Dialysis Using Hypertonic Glucose Solution: A Retrospective Cohort Study: Chinakorn Sujimongkol, Cholatip Pongskul, Supannee Promthet; J Prev Med Public Health. 2018;51(4):205-212. Published online June 19, 2018; DOI: https://doi.org/10.3961/jpmph.18.066

4,725 View
136 Download
1 Crossref

Objectives
The main purpose of this study was to quantify the risk of mortality linked to various regimens of hypertonic peritoneal dialysis (PD) solution.
Methods
A retrospective cohort study of patients using home-based PD was carried out. The prescribed regimen of glucose-based PD solution for all patients, determined on the basis of their individual conditions, was extracted from their medical chart records. The primary outcome was death. The treatment regimens were categorized into 3 groups according to the type of PD solution used: original PD (1.5% glucose), shuffle PD (1.5 and 2.5% glucose), and serialized PD (2.5 and 4.5% glucose). Multivariate analysis (using the Weibull model) was applied to comprehensively examine survival probabilities related to the explanatory variable, while adjusting for other potential confounders.
Results
Of 300 consecutive patients, 38% died over a median follow-up time of 30 months (interquartile range: 15-46 months). Multivariate analysis showed that a treatment regimen with continued higher-strength PD solution (serialized PD) resulted in a lower survival rate than when the conventional strength solution was used (adjusted hazard ratio, 2.6; 95% confidence interval, 1.6 to 4.6, p<0.01). Five interrelated risk factors (age, length of time on PD, hemoglobin levels, albumin levels, and oliguria) were significant predictors contributing to the outcome.
Conclusions
Frequent exposure to high levels of glucose PD solution significantly contributed to a 2-fold higher rate of death, especially when hypertonic glucose was prescribed continuously.

Summary

Citations

Citations to this article as recorded by

Associations of Glucometabolic Indices with Aortic Stiffness in Patients Undergoing Peritoneal Dialysis with and without Diabetes Mellitus
Chi-Chong Tang, Jen-Pi Tsai, Yi-Hsin Chen, Szu-Chun Hung, Yu-Li Lin, Bang-Gee Hsu
International Journal of Molecular Sciences.2023; 24(23): 17094. CrossRef

English Abstract

Survival Rates of the 5 Major Cancers in Jeju Island Residents, 2000-2001.: Yeong Ja Yang, Jong Myon Bae; J Prev Med Public Health. 2007;40(3):213-217.; DOI: https://doi.org/10.3961/jpmph.2007.40.3.213

4,118 View
27 Download
3 Crossref

Abstract PDF

OBJECTIVES
This study aimed to calculate the survival rates of cancer patients in Jeju Island residents from 2000 to 2001, based on their major primary sites of occurrence. METHODS: Data were extracted from the database of the Jejudo Cancer Registry (JCR). The eligible population comprised 2,382 cancer cases, whose cancers were diagnosed from 1 January 2000 through 31 December 2001. Of the eligible population, 1,438 patients with 5 major cancers defined by the level of incidence rates were selected as the study participants. The period of survival for each case was calculated from the date of first diagnosis to the date of death, or the end of follow-up, i.e., 31 December 2003. The observed survival rates (OSR) and relative survival rates (RSR) were calculated according to sex, age-group, and primary sites of occurrence. RESULTS: The 3-year OSR and RSR in 5 major cancers were higher in women than in men except 75 year-old over group. The 3-year RSR of stomach, colorectum, liver, and lung in both sexes were 61.0%, 62.6%, 24.7%, and 22.8%, respectively. The respective rates in JCR showed some statistically significant differences from those in the Korea Central Cancer Registry (KCCR). CONCLUSIONS: These results would suggest some clues about prognostic factors of major cancers in Korean, and could apply to planning and evaluating of cancer control strategies in Jeju Island.

Summary

Citations

Citations to this article as recorded by

The study for the Epidemiologic Characteristics of Cancer Patients in Jeju Special Self-governing Province
Weon-Young Chang
Journal of the Korea Academia-Industrial cooperation Society.2015; 16(2): 1292. CrossRef
Characteristics of Gastric Cancer in Korea - with an Emphasis on the Increase of the Early Gastric Cancer (EGC)
Ki Joo Kang, Jun Haeng Lee
Journal of the Korean Medical Association.2010; 53(4): 283. CrossRef
Explaining Cancer Incidence in the Jejudo Population
Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2009; 42(1): 67. CrossRef

First
Prev
Page of 1
Next
Last

Search