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Journal of Preventive Medicine and Public Health 2006;39(6): 493-498.
Fasting Serum Glucose Level and Gastric Cancer Risk in a Nested Case-control Study.
Jae Kwan Jun, Jin Gwack, Sue Kyung Park, Yun Hee Choi, Yeonju Kim, Aesun Shin, Soung Hoon Chang, Hai Rim Shin, Keun Young Yoo
1Department of Preventive Medicine, Seoul National University College of Medicine, Korea. kyyoo@plaza.snu.ac.kr
2Center for Health Services Research, Vanderbilt University Medical Center, Korea.
3Department of Preventive Medicine, College of Medicine, Konkuk University, Korea.
4Research Institute for National Cancer Control and Evaluation, National Cancer Center, Korea.
5National Cancer Center, Korea.
ABSTRACT
OBJECTIVES: Diabetes has been reported as a risk factor for several cancers. However, the association between diabetes and gastric cancer has been inconsistent. The aim of this study was to evaluate the association between the fasting serum glucose level and gastric cancer risk in Korea. METHODS: Among the members of the Korean Multi-Center Cancer Cohort (KMCC) from 1993 to 2004, a total of 100 incident gastric cancer cases were ascertained until December 31, 2002 and 400 controls were matched according to age, sex, and year and area of enrollment. Of the eligible subjects, those without fasting serum glucose level information were excluded, with a total of 64 cases and 236 controls finally selected. On enrollment, all subjects completed a baseline demographic and lifestyle characteristics questionnaire, and had their fasting serum glucose level measured. The Helicobacter pylori infection status was determined by an immunoblot assay using longterm stored serum. The odds ratios (ORs) were estimated using conditional and unconditional logistic regression models adjusted for the H. pylori infection status, smoking, drinking, education, follow-up period and matching variables. RESULTS: The ORs for risk of gastric cancer according to the serum glucose level were 1.33 [95% CI=0.50-3.53] and 1.66 [95% CI=0.55-5.02] for the categories of 100-125 and 126 mg/dL or greater, respectively, compared to the category of less than 100 mg/dL. No increased risk of gastric cancer according to the serum glucose level was found (p-trend=0.337). CONCLUSIONS: This study provides no evidence for an association of the serum glucose level with gastric cancer.
Key words: Gastric cancer; Fasting serum glucose; Nested case-control study; Korea
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