Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > Korean J Prev Med > Volume 29(1); 1996 > Article
Original Article Scientific rationale and applicability of dose-reponse models for environmental carcinogens.
Dongchun Shin, Yong Chung, Jongman Kim, Seongim G Lee, Mansik Hwang
Journal of Preventive Medicine and Public Health 1996;29(1):27-42
DOI: https://doi.org/
  • 1,724 Views
  • 20 Download
  • 0 Crossref
  • 0 Scopus

This study described methods to predict human health risk associated with exposure to environmental carciongens using animal bioassay data. Also, biological assumption for various dose-response models were reviewed. To illustrate the process of risk estimate using relevant dose-response models such as Log-normal, Mantel-Bryan, Weibull and Multistage model, we used four animal carcinogenesis bioassy data of chloroform and chloroform concentrations of tap water measured in large cities of korea from 1987 to 1995. As a result, in the case of using average concentration in exposure data and 95 % upper boud unit risk of Multistage model, excess cancer risk(RISK I) was about 1.9 x 10-6, in the case of using probability distribution of cumulative exposure data and unit risks, those risks(RISK II) which were simulated by Monte-Carlo analysis were about 2.4 x 10(-6) and 7.9 x 10(-5) at 50 and 95 percentile, respectively. Therefore risk estimated by Monte-Carlo analysis using probability distribution of input variables may be more conservative.

Related articles

JPMPH : Journal of Preventive Medicine and Public Health