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Korean Journal of Preventive Medicine 1985;18(1): 91-98.
Complement Activation by Tobacco Infusion.
Myung Ho Chung, Doo Hie Kim, Tae Ho Chung
1Graduate School of Public Health, Kyungpook National University, Taegu, Korea.
2Kyungpook National University, School of Medicine, Korea.
ABSTRACT
The capacity of tobacco infusions of Korean cigarettes to activate the complement pathway was investigated in vitro by hemolytic assay. Complement activity was studied using samples of normal rabbit serum incubated at 37 degrees C with tobacco infusions. In all mixtures containing tobacco infusion A, B, C, D, E, F, G, H and I at a concentration of 0.1 : 1, total hemolytic complement showed a progressive decrease of 55.92%, 48.62%, 42.89%, 49.12%, 42.26%, 52.26%, 71.96%, 60.90%, and 61.14% respectively, after 60min of incubation. This study suggests that all tobacco infusions of Korean cigarettes are activators of complement.
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