Journal of Preventive Medicine and Public Health

Original Articles

Association Between Prolonged Sedentary Time and Elevated High-sensitivity C-reactive Protein Among Korean Adults Aged 65 Years or Older: KNHANES 2022: Roma Seol, Chaemin Chun, Sang Ok Cho; J Prev Med Public Health. 2026;59(4):373-380. Published online July 13, 2026; DOI: https://doi.org/10.3961/jpmph.26.091

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Abstract Summary PDF: Objectives
Sedentary behavior has emerged as a health risk factor distinct from insufficient physical activity. This study examined the association between sedentary time and high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, among Korean older adults.
Methods
Data were obtained from the 2022 Korea National Health and Nutrition Examination Survey. Among 1667 participants aged 65 years or older with available hs-CRP measurements, 496 with leukocyte counts ≥10 000 cells/mm3 or hs-CRP levels ≥10.0 mg/L were excluded, yielding a final sample of 1171 participants. hs-CRP levels ≥1.0 mg/L were classified as abnormal. Differences in the prevalence of abnormal hs-CRP were assessed using the chi-square test, and multivariable logistic regression analysis was performed to evaluate the association between sedentary time and abnormal hs-CRP after adjustment for covariates.
Results
The prevalence of abnormal hs-CRP was higher among participants who did not engage in regular walking (prevalence ratio [PR], 1.24; 95% confidence interval [CI], 1.05 to 1.46) and those with adverse cardiometabolic profiles, including elevated blood pressure, dyslipidemia, and abdominal obesity. It was also higher among participants with sedentary time ≥10 hr/day (PR, 1.20; 95% CI, 1.02 to 1.41). In multivariable logistic regression analysis, prolonged sedentary time remained associated with abnormal hs-CRP levels after adjustment for covariates (odds ratio, 1.31; 95% CI, 1.01 to 1.71).
Conclusions
Prolonged sedentary time was independently associated with elevated hs-CRP levels among Korean adults aged 65 years or older. Accordingly, sedentary behavior reduction may be a useful target for chronic disease prevention strategies in older populations.; Summary

Korean summary
2022년 국민건강영양조사 자료를 분석한 결과, 65세 이상 한국 노인에서 하루 10시간 이상의 장시간 좌식행동은 높은 hs-CRP 수준과 독립적으로 관련되었다. 본 연구는 노인의 만성질환 예방과 건강한 노화를 위해 신체활동 증진뿐만 아니라 장시간 좌식행동을 줄이는 전략도 중요할 수 있음을 시사한다.

Key Message
Among Korean adults aged 65 years or older, sedentary time of ≥10 hr/day was independently associated with elevated high-sensitivity C-reactive protein (hs-CRP) levels. These findings suggest that reducing prolonged sedentary time, alongside promoting physical activity, may be an important behavioral target for chronic disease prevention and healthy aging.

The Relationship Between Thiamine Intake and Long Sleep Duration: Results From the Korea National Health and Nutrition Examination Survey: Dongkyu Lee, Kwanghyun Kim, Youngrong Lee, Kyungwon Oh, Sun Jae Jung; J Prev Med Public Health. 2022;55(6):520-528. Published online October 14, 2022; DOI: https://doi.org/10.3961/jpmph.22.313

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Abstract Summary PDF Supplementary Material

Objectives
Thiamine is thought to modify sleeping patterns, while alcohol use diminishes internal thiamine levels. We investigated the association between thiamine intake and sleep duration and explored possible heterogeneity in the effect according to alcohol use.
Methods
In total, 15 384 participants aged 19-64 were obtained from the Korea National Health and Nutrition Examination Survey 2012-2016. Nutrient intake, including thiamine, was measured using a food frequency questionnaire. Sleep duration was measured by a self-reported questionnaire. The highest thiamine intake quartile was set as the reference group. Participants were divided into 3 groups, with 7-8 hours of daily sleep as a reference group and those who slept more or less than that as “oversleeping” and “insufficient sleeping,” respectively. Multivariate logistic regression was used, adjusting for socioeconomic, medical, and nutritional factors. Additionally, participants were stratified according to high-risk alcohol use defined by the World Health Organization standards on alcohol use.
Results
Low thiamine intake was associated with oversleeping (Q3: odds ratio [OR], 1.06; 95% confidence interval [CI], 0.86 to 1.32; Q2: OR, 1.24; 95% CI, 0.99 to 1.55; Q1: OR, 1.49; 95% CI, 1.16 to 1.91) and showed a significant trend for higher ORs at lower intake levels (p-trend<0.001). The effect was stronger in the high-risk alcohol use group (Q1: OR, 1.78; 95% CI, 1.28 to 2.49).
Conclusions
Low thiamine intake was associated with oversleeping, and alcohol use intensified that association. These results were found in a context where overt clinical symptoms due to thiamine deficiency are considered rare. More awareness of the potential relationship of thiamine intake with oversleeping and its related risks should be considered.

Summary

Korean summary
국민건강영양조사 자료에서 낮은 비타민 B1 섭취가 과도한 수면시간과 연관성이 있으며, 고위험 알코올 섭취군에서 더 큰 상관성을 보였다. 현저한 임상 증상이 나타나지 않는 선에서의 섭취부족도 잠재적으로 과도한 수면시간 및 이와 관련된 건강에 대한 부정적 효과들과 관련이 있을 수 있어 주의가 필요하다.

Citations

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Giuseppe Losurdo, Francesco Squeo, Angela Marotti, Antonio Giangaspero, Enzo Ierardi, Mariabeatrice Principi
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Yingxuan Tao, Murong Wu, Boyao Su, Heng Lin, Qianzi Li, Yuhong He, Tian Zhong, Ying Xiao, Xi Yu
Nutrients.2025; 17(11): 1894. CrossRef
Daytime-Dependent Effects of Thiamine on the Thiamine Pool and Pyruvate Dehydrogenase Regulation in the Brain and Heart
Vasily Aleshin, Nadejda Borisova, Artem Artiukhov, Kurban Tagirov, Olga Solovjeva, Eva Lavrenteva, Nikolay Panin, Maria Maslova, Anastasia Graf
International Journal of Molecular Sciences.2025; 26(17): 8296. CrossRef
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Associations of Handgrip Strength and Handgrip Strength Asymmetry With Depression in the Elderly in Korea: A Cross-sectional Study: Kyungduk Hurh, Yoonsik Park, Gyu Ri Kim, Sung-In Jang, Eun-Cheol Park; J Prev Med Public Health. 2021;54(1):63-72. Published online December 30, 2020; DOI: https://doi.org/10.3961/jpmph.20.315

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193 Download
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Abstract Summary PDF Supplementary Material

Objectives
Recent studies have suggested that assessing handgrip strength (HGS) asymmetry together with HGS may be helpful for evaluating problems in geriatric patients. This study aimed to identify whether HGS asymmetry, weakness, or both were associated with depression in Korean older adults.
Methods
This study included 4274 subjects from the sixth and seventh Korea National Health and Nutrition Examination Survey. Depression was measured using the Patient Health Questionnaire-9. The maximum HGS of the dominant hand was used as a representative value. HGS symmetry was categorized by the ratio of the HGS of the dominant hand to that of non-dominant hand. The odds ratio (OR) for depression was calculated according to the HGS and its symmetry.
Results
In total, 240 (12.5%) men and 534 (22.7%) women had depression. HGS or HGS asymmetry showed no statistically significant associations with depression in elderly men. Elevated odds of depression were observed in elderly women with low HGS (OR, 1.93; 95% confidence interval [CI], 1.33 to 2.81) or prominent HGS asymmetry (OR, 1.46; 95% CI, 1.02 to 2.08). There was a positive additive interaction between asymmetric HGS and weakness, as women with low and prominently asymmetric HGS showed higher odds of depression (OR, 3.77; 95% CI, 2.16 to 6.59) than women with high and symmetric HGS.
Conclusions
Depression in elderly Korean women was associated with both low and asymmetric HGS. Our findings support the potential value of HGS asymmetry as an indicator of HGS.

Summary

Korean summary
본 연구에서는 국민건강영양조사 자료를 이용하여, 국내 60세 이상 노인 인구에서 악력 저하 및 양손 악력의 비대칭과 우울증 유병과의 상관관계를 분석하였다. 분석 결과 60세 이상 여성에서 악력 저하 및 양손 악력의 비대칭이 우울증 유병과 관련이 있었으며, 악력 저하와 비대칭이 동반된 경우에는 우울증 유병에 대하여 상가작용이 존재하였다. 이는 향후 노인의 악력 측정 시, 양손 악력의 비대칭에 대하여도 주목할 필요가 있음을 시사한다.

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