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- Levothyroxine Dose and Fracture Risk According to the Osteoporosis Status in Elderly Women
- Young-Jin Ko, Ji Young Kim, Joongyub Lee, Hong-Ji Song, Ju-Young Kim, Nam-Kyong Choi, Byung-Joo Park
- J Prev Med Public Health. 2014;47(1):36-46. Published online January 29, 2014
- DOI: https://doi.org/10.3961/jpmph.2014.47.1.36
- 12,038 View
- 171 Download
- 23 Crossref
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Abstract
PDF Objectives To evaluate the association between fracture risk and levothyroxine use in elderly women with hypothyroidism, according to previous osteoporosis history.
Methods We conducted a cohort study from the Korean Health Insurance Review and Assessment Service claims database from January 2005 to June 2006. The study population comprised women aged ≥65 years who had been diagnosed with hypothyroidism and prescribed levothyroxine monotherapy. We excluded patients who met any of the following criteria: previous fracture history, hyperthyroidism, thyroid cancer, or pituitary disorder; low levothyroxine adherence; or a follow-up period <90 days. We categorized the daily levothyroxine doses into 4 groups: ≤50 µg/d, 51 to 100 µg/d, 101 to 150 µg/d, and >150 µg/d. The hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with the Cox proportional hazard model, and subgroup analyses were performed according to the osteoporosis history and osteoporosis-specific drug prescription status.
Results Among 11 155 cohort participants, 35.6% had previous histories of osteoporosis. The adjusted HR of fracture for the >150 µg/d group, compared with the 51 to 100 µg/d group, was 1.56 (95% CI, 1.03 to 2.37) in osteoporosis subgroup. In the highly probable osteoporosis subgroup, restricted to patients who were concurrently prescribed osteoporosis-specific drugs, the adjusted HR of fracture for the >150 µg/d group, compared with the 51 to 100 µg/d group, was 1.93 (95% CI, 1.14 to 3.26).
Conclusions While further studies are needed, physicians should be concerned about potential levothyroxine overtreatment in elderly osteoporosis patients.
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Citations
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Reviews in Endocrine and Metabolic Disorders.2024;[Epub] CrossRef - Evaluation and Management of Bone Health in Patients with Thyroid Diseases: A Position Statement of the Korean Thyroid Association
A Ram Hong, Ho-Cheol Kang
Endocrinology and Metabolism.2023; 38(2): 175. CrossRef - Refractory Hypothyroidism: Unraveling the Complexities of Diagnosis and Management
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Endocrine Practice.2023; 29(12): 1007. CrossRef - Assessing the cardiovascular effects of levothyroxine use in an ageing United Kingdom population (ACEL-UK) protocol: a cohort and target trial emulation study
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International Journal of Thyroidology.2022; 15(1): 1. CrossRef - Levothyroxine Therapy in Elderly Patients With Hypothyroidism
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British Dental Journal.2021; 231(1): 33. CrossRef - The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review
Dragos Apostu, Ondine Lucaciu, Daniel Oltean-Dan, Alexandru-Dorin Mureșan, Cristina Moisescu-Pop, Andrei Maxim, Horea Benea
Diagnostics.2020; 10(3): 149. CrossRef - Comparison of the efficacy between once-monthly oral ibandronate and risedronate among Korean women with osteoporosis: a nationwide population-based study
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Osteoporosis International.2019; 30(3): 659. CrossRef - The effect of thyroid functions on osteopenia of prematurity in preterm infants
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Journal of Pediatric Endocrinology and Metabolism.2019; 32(1): 65. CrossRef - Understanding hypothyroidism in Unani medicine
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JBJS Reviews.2019; 7(6): e6. CrossRef - Effect of sodium levothyroxine on histomorphometry, histopathology, histochemistry, and immunohistochemistry of articular cartilage in female mice
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Comparative Clinical Pathology.2018; 27(1): 45. CrossRef - High Prevalence of Radiological Vertebral Fractures in Women on Thyroid-Stimulating Hormone–Suppressive Therapy for Thyroid Carcinoma
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The Journal of Clinical Endocrinology & Metabolism.2018; 103(3): 956. CrossRef - Subclinical thyrotoxicosis and bone
M. Doga, A.M. Formenti, S. Frara, M. Memo, A. Giustina, G. Mazziotti
Current Opinion in Endocrine and Metabolic Researc.2018;[Epub] CrossRef - Effects of Abnormal Thyroid Function Status to Bone Metabolism
Hwa Young Ahn
International Journal of Thyroidology.2018; 11(1): 21. CrossRef - RETRACTED ARTICLE: The relationship between subclinical thyroid dysfunction and the risk of fracture or low bone mineral density: a systematic review and meta-analysis of cohort studies
Ruifei Yang, Liang Yao, Yuan Fang, Jing Sun, Tiankang Guo, Kehu Yang, Limin Tian
Journal of Bone and Mineral Metabolism.2018; 36(2): 209. CrossRef - MANAGEMENT OF ENDOCRINE DISEASE: l-Thyroxine replacement therapy in the frail elderly: a challenge in clinical practice
R M Ruggeri, F Trimarchi, B Biondi
European Journal of Endocrinology.2017; 177(4): R199. CrossRef - THE IMPACT OF AGE IN THE MANAGEMENT OF HYPOTHYROIDISM: RESULTS OF A NATIONWIDE SURVEY
Maria Papaleontiou, Brittany L. Gay, Nazanene H. Esfandiari, Sarah T. Hawley, Megan R. Haymart
Endocrine Practice.2016; 22(6): 708. CrossRef - TSH Suppression after Differentiated Thyroid Cancer Surgery and Osteoporosis
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Korean Journal of Endocrine Surgery.2016; 16(1): 1. CrossRef - TSH Suppression after Differentiated Thyroid Cancer Surgery and Osteoporosis
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Korean Journal of Endocrine Surgery.2016; 16(1): 1. CrossRef - Role of Thyroid Hormones in Skeletal Development and Bone Maintenance
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Endocrine Reviews.2016; 37(2): 135. CrossRef
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