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J Prev Med Public Health > Volume 43(3); 2010 > Article
Journal of Preventive Medicine and Public Health 2010;43(3): 213-221. doi: https://doi.org/10.3961/jpmph.2010.43.3.213
The Association Between Apolipoprotein E Genotype and Lipid Profiles in Healthy Woman Workers.
Kieun Moon, Sook Hee Sung, Youn Koun Chang, Il Keun Park, Yun Mi Paek, Soo Geun Kim, Tae In Choi, Young Woo Jin
1Division of Health Management, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD., Korea.
2Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Korea.
3Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD., Korea. ywjin@khnp.co.kr
OBJECTIVES: Plasma lipid profiles and Apolipoprotein E (ApoE) are established risk factors for cardiovascular disease (CVD). The knowledge of lipid profile may estimate the potential victims of cardiovascular disease before its initiation and progression and offers the opportunity for primary prevention. The most common ApoE polymorphism has been found to influence plasma lipid concentrations and its correlation with CVD has been extensively investigated in the last decade. METHODS: The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. The information on confounding factors was obtained through a self-administered questionnaire and ApoE polymorphism was investigated using PCR. RESULTS: The relative frequencies of alleles E2, E3 and E4 for the study population (n=305) were 0.127, 0.750 and 0.121, respectively. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile. In order to estimate the independent effects of alleles E2 and E4, as compared with E3, on lipid profile, multiple regression was performed after adjustment for confounding variables such as age, BMI, blood pressure, education status, insulin, fasting glucose, HOMA-IR, menopause. ApoE2 had a negative association with HDL cholesterol and ApoE4 had a positive association with LDL cholesterol. CONCLUSIONS: This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.
Key words: Apolipoprotein E; Cardiovascular disease; Cholesterol; Triglyceride; Koreans; Women's health
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