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Original Articles
- Are Serum Vitamin D Levels Associated With Dry Eye Disease? Results From the Study Group for Environmental Eye Disease
- Da-Hye Jeon, Hyungseon Yeom, Jaewon Yang, Jong Suk Song, Hyung Keun Lee, Hyeon Chang Kim
- J Prev Med Public Health. 2017;50(6):369-376. Published online November 2, 2017
- DOI: https://doi.org/10.3961/jpmph.17.089
- 6,016 View
- 179 Download
- 14 Crossref
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Abstract
PDF - Objectives
Dry eye disease (DED) is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI).
Methods
The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015). This group included data from 752 participants, and data from 740 participants (253 men and 487 women) were analyzed in the present study. DED severity was evaluated using the OSDI.
Results
Higher serum vitamin D levels were associated with a non-significantly reduced risk of DED in the crude analysis (odds ratio [OR], 0.991; 95% confidence interval [CI], 0.971 to 1.011) and in the adjusted analysis (OR, 0.988; 95% CI, 0.966 to 1.010). In the crude analysis of no/mild DED vs. moderate/severe DED, men exhibited a decreased risk with increasing serum vitamin D levels (OR, 0.999; 95% CI, 0.950 to 1.051), while women exhibited an increased risk (OR, 1.003; 95% CI, 0.979 to 1.027). In these analyses, we found no significant associations.
Conclusions
The findings of the present study support previous reports that serum vitamin D levels are not associated with DED. -
Summary
Citations
Citations to this article as recorded by
- Dry Eye Disease: What Is the Role of Vitamin D?
Maurizio Rolando, Stefano Barabino
International Journal of Molecular Sciences.2023; 24(2): 1458. CrossRef - Association of serum 25-hydroxyvitamin D concentrations with Schirmer tear test 1 and tear film breakup time in dogs
Youngsam Kim, Seonmi Kang, Kangmoon Seo
Journal of Veterinary Science.2023;[Epub] CrossRef - Vitamin D and eye: Current evidence and practice guidelines
Bhavya Gorimanipalli, Rohit Shetty, Swaminathan Sethu, Pooja Khamar
Indian Journal of Ophthalmology.2023; 71(4): 1127. CrossRef - Serum Vitamin D Levels and Dry Eye Disease in Postmenopausal Women: A Case–Control Study at a Tertiary Care Center in Rural Haryana
Diksha Malik, Renu Garg, Sumita Sethi, Rajiv Mahendru, Sanjeet Singh
International Journal of Applied & Basic Medical Research.2023; 13(2): 83. CrossRef - Vitamin D and Ocular Diseases: A Systematic Review
Hei-Nga Chan, Xiu-Juan Zhang, Xiang-Tian Ling, Christine Huyen-Trang Bui, Yu-Meng Wang, Patrick Ip, Wai-Kit Chu, Li-Jia Chen, Clement C. Tham, Jason C. Yam, Chi-Pui Pang
International Journal of Molecular Sciences.2022; 23(8): 4226. CrossRef - Oral vitamin D3 supplementation for femtosecond LASIK-associated dry eye vitamin D for LASIK dry eye syndrome
Ying Lin, Huanjun Su, Jianbin Wu, Muzhi Yuan, Yong Zhang
International Ophthalmology.2022; 42(10): 3145. CrossRef - Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases
Miłosz Caban, Urszula Lewandowska
Nutrients.2022; 14(11): 2353. CrossRef - Serum Vitamin D Levels and Status in Thai Optic Neuritis Subjects: A Case-Control Study
Busayanut Puangsricharoen, Kavin Vanikieti, Panitha Jindahra, Tanyatuth Padungkiatsagul
Clinical Ophthalmology.2022; Volume 16: 3381. CrossRef - Research on mechanism of vitamin A combined with regenerated oxidation-reducing nanomedicine in treating rats with dry eye
Lei Shi, Ting-Yu Li, Liang-Yu Li, Bao-Ke Hou
Materials Express.2022; 12(7): 886. CrossRef - Genistein‐Calcitriol Mitigates Hyperosmotic Stress‐Induced TonEBP, CFTR Dysfunction, VDR Degradation and Inflammation in Dry Eye Disease
Trailokyanath Panigrahi, Sharon D’Souza, Rohit Shetty, Archana Padmanabhan Nair, Anuprita Ghosh, Everette Jacob Remington Nelson, Arkasubhra Ghosh, Swaminathan Sethu
Clinical and Translational Science.2021; 14(1): 288. CrossRef - Association Between Dyslipidemia and Dry Eye Syndrome Among the Korean Middle-Aged Population
Hye Rin Choi, Jung Hyun Lee, Hyung Keun Lee, Jong Suk Song, Hyeon Chang Kim
Cornea.2020; 39(2): 161. CrossRef - Association between vitamin D and dry eye disease: A systematic review and meta-analysis of observational studies
Gholamreza Askari, Nahid Rafie, Maryam Miraghajani, Zahra Heidari, Arman Arab
Contact Lens and Anterior Eye.2020; 43(5): 418. CrossRef - Vitamin D deficiency is associated with dry eye syndrome: a systematic review and meta‐analysis
Jing Liu, Yi Dong, Yan Wang
Acta Ophthalmologica.2020; 98(8): 749. CrossRef - Nutrition and dry eye: a systematic review
Isabel Signes-Soler, Jaime Javaloy Estañ
Expert Review of Ophthalmology.2019; 14(3): 133. CrossRef
- Interaction of Vitamin D and Smoking on Inflammatory Markers in the Urban Elderly
- Hyemi Lee, Kyoung-Nam Kim, Youn-Hee Lim, Yun-Chul Hong
- J Prev Med Public Health. 2015;48(5):249-256. Published online September 17, 2015
- DOI: https://doi.org/10.3961/jpmph.15.042
- 9,779 View
- 132 Download
- 12 Crossref
-
Abstract
PDF
Supplementary Material - Objectives
Epidemiological studies have reported that vitamin D deficiency is associated with inflammatory disease. Smoking is a well-known risk factor for inflammation. However, few studies have investigated the interactive effect of vitamin D deficiency and smoking on inflammation. This study aims to investigate the interaction of vitamin D and smoking with inflammatory markers in the urban elderly.
Methods
We used data from the Korean Elderly Environmental Panel Study, which began in August 2008 and ended in August 2010, and included 560 Koreans ≥60 years old living in Seoul. Data was collected via questionnaires that included items about smoking status at the first visit. Vitamin D levels, high-sensitivity C-reactive protein (hs-CRP), and white blood cell (WBC) counts were repeatedly measured up to three times.
Results
The association of vitamin D and hs-CRP was significant after adjusting for known confounders (β=-0.080, p=0.041). After separate analysis by smoking status, the association of vitamin D deficiency and hs-CRP in smokers was stronger than that in nonsmokers (smokers: β=-0.375, p=0.013; non-smokers: β=-0.060, p=0.150). Smoking status was an effect modifier that changed the association between vitamin D deficiency and hs-CRP (interaction estimate: β=-0.254, p=0.032). Vitamin D was not significantly associated with WBC count (β=0.003, p=0.805).
Conclusions
Vitamin D deficiency was associated with hs-CRP in the urban elderly. Smoking status was an effect modifier of this association. Vitamin D deficiency was not significantly associated with WBC count. -
Summary
Citations
Citations to this article as recorded by- Identification of trans-genus biomarkers for early diagnosis of intestinal schistosomiasis and progression of gut pathology in a mouse model using metabolomics
Peerut Chienwichai, Phornpimon Tipthara, Joel Tarning, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Nuttapohn Kiangkoo, Poom Adisakwattana, Onrapak Reamtong, Gabriel Rinaldi
PLOS Neglected Tropical Diseases.2024; 18(2): e0011966. CrossRef - Vitamin D Status of People 3 to 79 Years of Age from the Canadian Health Measures Survey 2012–2019
Hope A. Weiler, Kurtis Sarafin, Chantal Martineau, Janice L. Daoust, Krista Esslinger, Linda S. Greene-Finestone, Lidia Loukine, Veronique Dorais
The Journal of Nutrition.2023; 153(4): 1150. CrossRef - Analysis of different risk factors of hospitalized COVID-19 patients from North-Eastern Bangladesh
Mohammad Golam Rob Mahmud, Md. Toasin Hossain Aunkor, Fatima Rahman, Darimi Hasin, Jilwatun Noor, Md. Faruque Miah
Journal of Clinical and Experimental Investigations.2023; 14(3): em00818. CrossRef - C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians
Dimitra S. Mouliou
Diseases.2023; 11(4): 132. CrossRef - Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin
Rachida Rafiq, Hassana El Haddaoui, Renée de Mutsert, Frits R. Rosendaal, Pieter S. Hiemstra, Christa M. Cobbaert, Martin den Heijer, Renate T. de Jongh
Cytokine.2020; 131: 155104. CrossRef - The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk
Amy M Lavery, Bradley N Collins, Amy T Waldman, Chantelle N Hart, Amit Bar-Or, Ruth Ann Marrie, Douglas Arnold, Julia O’Mahony, Brenda Banwell
Multiple Sclerosis Journal.2019; 25(4): 515. CrossRef - A Review of the Potential Benefits of Increasing Vitamin D Status in Mongolian Adults through Food Fortification and Vitamin D Supplementation
William B. Grant, Barbara J. Boucher
Nutrients.2019; 11(10): 2452. CrossRef - Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients
Qiongzhang Wang, Zhuoying Zhu, Yuntao Liu, Xinjie Tu, Jincai He
Brain and Behavior.2018;[Epub] CrossRef - Prevalence of vitamin D deficiency and its associated factors among the urban elderly population in Hyderabad metropolitan city, South India
Palla Suryanarayana, Nimmathota Arlappa, Vadakattu Sai Santhosh, Nagalla Balakrishna, Pondey Lakshmi Rajkumar, Undrajavarapu Prasad, Banavath Bhoja Raju, Kommula Shivakeseva, Kondru Divya Shoshanni, Madabushi Seshacharyulu, Jagjeevan Babu Geddam, Prabhaka
Annals of Human Biology.2018; 45(2): 133. CrossRef - Relationship between vitamin D status and leukocytes in hospitalised cats
Helen F Titmarsh, Jennifer A Cartwright, Scott Kilpatrick, Donna Gaylor, Elspeth M Milne, Jacqueline L Berry, Nicholas X Bommer, Danièlle Gunn-Moore, Nicola Reed, Ian Handel, Richard J Mellanby
Journal of Feline Medicine and Surgery.2017; 19(4): 364. CrossRef - Vitamin D Status and Gestational Diabetes: Effect of Smoking Status during Pregnancy
Linda Dodds, Christy G. Woolcott, Hope Weiler, Anne Spencer, Jean‐Claude Forest, B. Anthony Armson, Yves Giguère
Paediatric and Perinatal Epidemiology.2016; 30(3): 229. CrossRef - Modification of the association between smoking status and severity of coronary stenosis by vitamin D in patients suspected of coronary heart disease
Kuibao Li, Xiyan Yang, Lefeng Wang, Mulei Chen, Wenshu Zhao, Li Xu, Xinchun Yang
Medicine.2016; 95(36): e4817. CrossRef
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