1Institute of Health and Environment, Seoul National University, Seoul, Korea
2Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
Copyright © 2016 The Korean Society for Preventive Medicine
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICT OF INTEREST
The authors have no conflicts of interest associated with the material presented in this paper.
SNP | Position1 | Type | Allele | Minor allele | MAF | n2 | HWE p-value |
---|---|---|---|---|---|---|---|
rs2042875 | 158078484 | Intron | A,T | A | 0.25 | 1455 | 0.73 |
rs3843489 | 158112801 | Intron | A,T | T | 0.17 | 1467 | 0.52 |
rs2116727 | 158125627 | Intron | C,T | T | 0.17 | 1465 | 0.35 |
rs1368298 | 158137003 | Coding-synon | C,T | T | 0.34 | 1467 | 0.30 |
rs10061900 | 158186120 | Intron | A,G | A | 0.47 | 1465 | 0.21 |
rs10070743 | 158190626 | Intron | C,T | T | 0.47 | 1467 | 0.27 |
rs4704967 | 158192277 | Intron | G,T | T | 0.42 | 1463 | 0.12 |
rs10056564 | 158193834 | Intron | C,T | C | 0.47 | 1464 | 0.30 |
rs6875710 | 158201004 | Intron | C,T | T | 0.26 | 1416 | 0.05 |
rs891903 | 158212216 | Intron | A,G | A | 0.26 | 1467 | 0.17 |
rs6556373 | 158292054 | Intron | A,C | A | 0.38 | 1467 | 0.58 |
rs4921537 | 158298841 | Intron | C,T | C | 0.42 | 1461 | 0.18 |
rs6556377 | 158326158 | Intron | C,T | T | 0.46 | 1467 | 0.64 |
rs13180086 | 158326920 | Intron | C,T | C | 0.46 | 1465 | 0.53 |
rs1363561 | 158395496 | Intron | A,G | G | 0.28 | 1465 | 0.05 |
rs1422672 | 158399979 | Intron | A,G | A | 0.48 | 1459 | 0.38 |
rs17717829 | 158402641 | Intron | C,T | C | 0.28 | 1467 | 0.08 |
rs10515787 | 158407789 | Intron | C,T | T | 0.39 | 1454 | 0.09 |
rs10515786 | 158408564 | Intron | A,G | G | 0.48 | 1442 | 0.25 |
rs10515789 | 158438993 | Intron | G,T | G | 0.35 | 1464 | 0.91 |
rs9637861 | 158445390 | Intron | C,G | C | 0.45 | 1465 | 0.83 |
rs7442845 | 158451346 | Intron | C,G | G | 0.12 | 1464 | 0.55 |
SNP |
G×E p for WC |
G×E p for WHR |
G×E p for VAT |
||||||
---|---|---|---|---|---|---|---|---|---|
Additive | Dominant | Recessive | Additive | Dominant | Recessive | Additive | Dominant | Recessive | |
rs2116727 | 0.538 | 0.364 | 0.704 | 0.846 | 0.814 | 0.987 | 0.355 | 0.973 | 0.012* |
rs1368298 | 0.278 | 0.400 | 0.329 | 0.329 | 0.618 | 0.207 | 0.038* | 0.148 | 0.034* |
rs10061900 | 0.026* | 0.010* | 0.312 | 0.052 | 0.0041* | 0.900 | 0.117 | 0.048* | 0.600 |
rs10070743 | 0.026* | 0.008* | 0.370 | 0.049* | 0.0031* | 0.924 | 0.090 | 0.036* | 0.543 |
rs4704967 | 0.012* | 0.008* | 0.170 | 0.034* | 0.0071* | 0.588 | 0.093 | 0.037* | 0.636 |
rs10056564 | 0.037* | 0.011* | 0.431 | 0.057 | 0.0041* | 0.961 | 0.146 | 0.053 | 0.726 |
rs6875710 | 0.404 | 0.392 | 0.661 | 0.321 | 0.388 | 0.494 | 0.042* | 0.058 | 0.158 |
rs891903 | 0.248 | 0.243 | 0.508 | 0.177 | 0.198 | 0.424 | 0.022* | 0.030* | 0.136 |
rs6556373 | 0.182 | 0.324 | 0.200 | 0.073 | 0.389 | 0.023* | 0.153 | 0.256 | 0.211 |
rs4921537 | 0.108 | 0.172 | 0.200 | 0.053 | 0.340 | 0.019* | 0.141 | 0.142 | 0.363 |
rs6556377 | 0.136 | 0.263 | 0.180 | 0.042* | 0.301 | 0.019* | 0.0071* | 0.123 | 0.0031* |
rs13180086 | 0.146 | 0.262 | 0.201 | 0.047* | 0.298 | 0.024* | 0.008* | 0.125 | 0.0041* |
rs1363561 | 0.139 | 0.096 | 0.781 | 0.069 | 0.093 | 0.270 | 0.008* | 0.034* | 0.020* |
rs17717829 | 0.140 | 0.096 | 0.787 | 0.068 | 0.093 | 0.264 | 0.008* | 0.034 | 0.020* |
rs10515789 | 0.027* | 0.015* | 0.358 | 0.067 | 0.035 | 0.521 | 0.164 | 0.266 | 0.226 |
Characteristics | Male (n=906) | Female (n=561) | Total (n=1467) | p-value |
---|---|---|---|---|
Age (y) | 55.77±7.0 | 57.31±7.8 | 56.36±7.4 | < 0.001 |
WC (cm) | 82.71±7.4 | 77.85±7.6 | 80.85±7.8 | <0.001 |
HC (cm) | 91.73±5.1 | 91.74±5.2 | 91.73±5.1 | 0.95 |
WHR | 0.90±0.0 | 0.85±0.1 | 0.88±0.1 | <0.001 |
VAT (cm2) | 81.18±37.2 | 76.56±34.1 | 79.41±36.1 | 0.01 |
Psychosocial stress | 0.001 | |||
Low | 82 (9.0) | 66 (11.8) | 148 (10.1) | |
Moderate | 713 (78.7) | 394 (70.2) | 1107 (75.5) | |
High | 111 (12.2) | 101 (18.0) | 212 (14.4) |
SNP | Position |
Type | Allele | Minor allele | MAF | n |
HWE p-value |
---|---|---|---|---|---|---|---|
rs2042875 | 158078484 | Intron | A,T | A | 0.25 | 1455 | 0.73 |
rs3843489 | 158112801 | Intron | A,T | T | 0.17 | 1467 | 0.52 |
rs2116727 | 158125627 | Intron | C,T | T | 0.17 | 1465 | 0.35 |
rs1368298 | 158137003 | Coding-synon | C,T | T | 0.34 | 1467 | 0.30 |
rs10061900 | 158186120 | Intron | A,G | A | 0.47 | 1465 | 0.21 |
rs10070743 | 158190626 | Intron | C,T | T | 0.47 | 1467 | 0.27 |
rs4704967 | 158192277 | Intron | G,T | T | 0.42 | 1463 | 0.12 |
rs10056564 | 158193834 | Intron | C,T | C | 0.47 | 1464 | 0.30 |
rs6875710 | 158201004 | Intron | C,T | T | 0.26 | 1416 | 0.05 |
rs891903 | 158212216 | Intron | A,G | A | 0.26 | 1467 | 0.17 |
rs6556373 | 158292054 | Intron | A,C | A | 0.38 | 1467 | 0.58 |
rs4921537 | 158298841 | Intron | C,T | C | 0.42 | 1461 | 0.18 |
rs6556377 | 158326158 | Intron | C,T | T | 0.46 | 1467 | 0.64 |
rs13180086 | 158326920 | Intron | C,T | C | 0.46 | 1465 | 0.53 |
rs1363561 | 158395496 | Intron | A,G | G | 0.28 | 1465 | 0.05 |
rs1422672 | 158399979 | Intron | A,G | A | 0.48 | 1459 | 0.38 |
rs17717829 | 158402641 | Intron | C,T | C | 0.28 | 1467 | 0.08 |
rs10515787 | 158407789 | Intron | C,T | T | 0.39 | 1454 | 0.09 |
rs10515786 | 158408564 | Intron | A,G | G | 0.48 | 1442 | 0.25 |
rs10515789 | 158438993 | Intron | G,T | G | 0.35 | 1464 | 0.91 |
rs9637861 | 158445390 | Intron | C,G | C | 0.45 | 1465 | 0.83 |
rs7442845 | 158451346 | Intron | C,G | G | 0.12 | 1464 | 0.55 |
SNP | G×E p for WC |
G×E p for WHR |
G×E p for VAT |
||||||
---|---|---|---|---|---|---|---|---|---|
Additive | Dominant | Recessive | Additive | Dominant | Recessive | Additive | Dominant | Recessive | |
rs2116727 | 0.538 | 0.364 | 0.704 | 0.846 | 0.814 | 0.987 | 0.355 | 0.973 | 0.012 |
rs1368298 | 0.278 | 0.400 | 0.329 | 0.329 | 0.618 | 0.207 | 0.038 |
0.148 | 0.034 |
rs10061900 | 0.026 |
0.010 |
0.312 | 0.052 | 0.004 |
0.900 | 0.117 | 0.048 |
0.600 |
rs10070743 | 0.026 |
0.008 |
0.370 | 0.049 |
0.003 |
0.924 | 0.090 | 0.036 |
0.543 |
rs4704967 | 0.012 |
0.008 |
0.170 | 0.034 |
0.007 |
0.588 | 0.093 | 0.037 |
0.636 |
rs10056564 | 0.037 |
0.011 |
0.431 | 0.057 | 0.004 |
0.961 | 0.146 | 0.053 | 0.726 |
rs6875710 | 0.404 | 0.392 | 0.661 | 0.321 | 0.388 | 0.494 | 0.042 |
0.058 | 0.158 |
rs891903 | 0.248 | 0.243 | 0.508 | 0.177 | 0.198 | 0.424 | 0.022 |
0.030 |
0.136 |
rs6556373 | 0.182 | 0.324 | 0.200 | 0.073 | 0.389 | 0.023 |
0.153 | 0.256 | 0.211 |
rs4921537 | 0.108 | 0.172 | 0.200 | 0.053 | 0.340 | 0.019 |
0.141 | 0.142 | 0.363 |
rs6556377 | 0.136 | 0.263 | 0.180 | 0.042 |
0.301 | 0.019 |
0.007 |
0.123 | 0.003 |
rs13180086 | 0.146 | 0.262 | 0.201 | 0.047 |
0.298 | 0.024 |
0.008 |
0.125 | 0.004 |
rs1363561 | 0.139 | 0.096 | 0.781 | 0.069 | 0.093 | 0.270 | 0.008 |
0.034 |
0.020 |
rs17717829 | 0.140 | 0.096 | 0.787 | 0.068 | 0.093 | 0.264 | 0.008 |
0.034 | 0.020 |
rs10515789 | 0.027 |
0.015 |
0.358 | 0.067 | 0.035 | 0.521 | 0.164 | 0.266 | 0.226 |
Values are presented as mean±SD or number (%). SD, standard deviation; WC, waist circumference; HC, hip circumference; WHR, waist-hip ratio; VAT, visceral adipose tissue.
SNP, single nucleotide polymorphism; SNP positions are based on Build 36 from the National Center for Biotechnology Information. Number of samples that were finally genotyped in this study.
SNP, single-nucleotide polymorphism; WC, waist circumference; WHR, waist-hip ratio; VAT, visceral adipose tissue. SNPs that meet the Bonferroni correction threshold of