| Home | E-Submission | Sitemap | Contact Us |  
top_img

Association between Atrial Fibrillation and the Risk of Dementia in the Korean Elderly: A 10-year Nationwide Cohort Study
Min Ah Nah, Kyeong Soo Lee , Tae Yoon Hwang
Department of Preventive Medicine & Public Health, Yeungnam University, Daegu, Korea
Corresponding Author: Kyeong Soo Lee ,Tel: +82-53-640-6953, Fax: +82-53-653-2061, Email: drkslee@ynu.ac.kr
Received: May 16, 2019;  Accepted: January 3, 2020.
ABSTRACT
Objectives:
The objective of this study was to determine the effect of atrial fibrillation (AF) on the risk of dementia in the Korean elderly.
Method:
A 10-year retrospective cohort study was conducted using the National Health Insurance Service-Senior Cohort (NHIS-SC) database. We excluded those who were under 65 years of age as of January 2006 (n=46??13), those who were diagnosed with dementia between 2002 and 2005 (n=9086), and those with a history of stroke prior to AF diagnosis (n=8392). We used a Cox proportional hazards model with a time-varying covariate to determine whether AF is associated with the risk of dementia after adjusting for potential confounders.
Results:
In univariable Cox regression, the hazard ratio (HR) of dementia according to AF status was 1.278 (95% confidence interval [CI], 1.277 to 1.331). After adjusting for potential confounders, AF was found to increase the risk of dementia (HR, 1.118; 95% CI, 1.073 to 1.116), Alzheimer dementia (HR, 1.121; 95% CI, 1.073 to 1.172), and vascular dementia (HR, 1.104; 95% CI, 1.032 to 1.181). In patients diagnosed with AF, the incidence of dementia was lower (HR, 0.495; 95% CI, 0.467 to 0.524) in patients who were treated with oral anticoagulants.
Conclusions:
Investigating the potential risk factors of dementia in an aged society is important. We found a slightly higher risk of dementia in those with AF than in those without AF, and we therefore concluded that AF is a potential risk factor for dementia.
Key words: Dementia; Atrial Fibrillation; Risk Factors; Primary Prevention
Editorial Office
Graduate School of Public Health, Seoul National University
1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
Tel : +82-2-740-8328   Fax : +82-2-764-8328   E-mail: jpmphe@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2020 by Korean Society for Preventive Medicine. All rights reserved.                 powerd by m2community