| Home | E-Submission | Sitemap | Contact Us |  

Association between Atrial Fibrillation and the Risk of Dementia in the Korean Elderly: A 10-year Nationwide Cohort Study
Min Ah Nah, Kyeong Soo Lee , Tae Yoon Hwang
Department of Preventive Medicine & Public Health, Yeungnam University, Daegu, Korea
Corresponding Author: Kyeong Soo Lee ,Tel: +82-53-640-6953, Fax: +82-53-653-2061, Email: drkslee@ynu.ac.kr
Received: May 16, 2019;  Accepted: January 3, 2020.
The objective of this study was to determine the effect of atrial fibrillation (AF) on the risk of dementia in the Korean elderly.
A 10-year retrospective cohort study was conducted using the National Health Insurance Service-Senior Cohort (NHIS-SC) database. We excluded those who were under 65 years of age as of January 2006 (n=46??13), those who were diagnosed with dementia between 2002 and 2005 (n=9086), and those with a history of stroke prior to AF diagnosis (n=8392). We used a Cox proportional hazards model with a time-varying covariate to determine whether AF is associated with the risk of dementia after adjusting for potential confounders.
In univariable Cox regression, the hazard ratio (HR) of dementia according to AF status was 1.278 (95% confidence interval [CI], 1.277 to 1.331). After adjusting for potential confounders, AF was found to increase the risk of dementia (HR, 1.118; 95% CI, 1.073 to 1.116), Alzheimer dementia (HR, 1.121; 95% CI, 1.073 to 1.172), and vascular dementia (HR, 1.104; 95% CI, 1.032 to 1.181). In patients diagnosed with AF, the incidence of dementia was lower (HR, 0.495; 95% CI, 0.467 to 0.524) in patients who were treated with oral anticoagulants.
Investigating the potential risk factors of dementia in an aged society is important. We found a slightly higher risk of dementia in those with AF than in those without AF, and we therefore concluded that AF is a potential risk factor for dementia.
Key words: Dementia; Atrial Fibrillation; Risk Factors; Primary Prevention
Editorial Office
Graduate School of Public Health, Seoul National University
1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
Tel : +82-2-740-8328   Fax : +82-2-764-8328   E-mail: jpmphe@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2020 by Korean Society for Preventive Medicine. All rights reserved.                 powerd by m2community